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101.
C. R. Foschini R. Tararam A. Z. Simões L. S. Rocha C. O. P. Santos E. Longo J. A. Varela 《Journal of Materials Science: Materials in Electronics》2016,27(3):2175-2182
Calcium copper titanate, CaCu3Ti4O12, CCTO, thin films with polycrystalline nature have been deposited by RF sputtering on Pt/Ti/SiO2/Si (100) substrates at a room temperature followed by annealing at 600 °C for 2 h in a conventional furnace. The crystalline structure and the surface morphology of the films were markedly affected by the growth conditions. Rietveld analysis reveal a CCTO film with 100 % pure perovskite belonging to a space group Im3 and pseudo-cubic structure. The XPS spectroscopy reveal that the in a reducing N2 atmosphere a lower Cu/Ca and Ti/Ca ratio were detected, while the O2 treatment led to an excess of Cu, due to Cu segregation of the surface forming copper oxide crystals. The film present frequency -independent dielectric properties in the temperature range evaluated, which is similar to those properties obtained in single-crystal or epitaxial thin films. The room temperature dielectric constant of the 600-nm-thick CCTO films annealed at 600 °C at 1 kHz was found to be 70. The leakage current of the MFS capacitor structure was governed by the Schottky barrier conduction mechanism and the leakage current density was lower than 10?7 A/cm2 at a 1.0 V. The current–voltage measurements on MFS capacitors established good switching characteristics. 相似文献
102.
Engineered Multifunctional Albumin‐Decorated Porous Silicon Nanoparticles for FcRn Translocation of Insulin
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João P. Martins Roberto D'Auria Dongfei Liu Flavia Fontana Mónica P. A. Ferreira Alexandra Correia Marianna Kemell Karina Moslova Ermei Mäkilä Jarno Salonen Luca Casettari Jouni Hirvonen Bruno Sarmento Hélder A. Santos 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(27)
The last decade has seen remarkable advances in the development of drug delivery systems as alternative to parenteral injection‐based delivery of insulin. Neonatal Fc receptor (FcRn)‐mediated transcytosis has been recently proposed as a strategy to increase the transport of drugs across the intestinal epithelium. FcRn‐targeted nanoparticles (NPs) could hijack the FcRn transcytotic pathway and cross the epithelial cell layer. In this study, a novel nanoparticulate system for insulin delivery based on porous silicon NPs is proposed. After surface conjugation with albumin and loading with insulin, the NPs are encapsulated into a pH‐responsive polymeric particle by nanoprecipitation. The developed NP formulation shows controlled size and homogeneous size distribution. Transmission electron microscopy (TEM) images show successful encapsulation of the NPs into pH‐sensitive polymeric particles. No insulin release is detected at acidic conditions, but a controlled release profile is observed at intestinal pH. Toxicity studies show high compatibility of the NPs with intestinal cells. In vitro insulin permeation across the intestinal epithelium shows approximately fivefold increase when insulin is loaded into FcRn‐targeted NPs. Overall, these FcRn‐targeted NPs offer a toolbox in the development of targeted therapies for oral delivery of insulin. 相似文献
103.
J. D. Santos P. L. Silva J. C. Knowles S. Talal F. J. Monteiro 《Journal of materials science. Materials in medicine》1996,7(3):187-189
Commercial hydroxyapatite was reinforced by adding small amounts (2 and 4 wt%) of P2O5-based glasses during its sintering process. The composites prepared had a chemical composition closely related to the mineral part of bone tissues in terms of trace elements usually detected, such as Na, K and Mg. X-ray diffraction analysis (XRD) showed that the glass reinforced-HA composites were composed of a HA matrix and variable amounts of tricalcium phosphate phase, depending on sintering temperature and glass composition. These composites were shown to have much higher biaxial bending strength than sintered HA, 107 MPa for Ha/2% of 35P2O5-35CaO-10Na2O-10K2O-10MgO glass composite and 28 MPa for sintered HA. The presence of -tricalcium phosphate in the microstructure of the composites is an important factor in the reinforcement process.This paper was accepted for publication after the 1995 Conference of the European Society of Biomaterials, Oporto. Portugal, 10–13 September. 相似文献
104.
This paper proposes a new approach for the segmentation of both near-end and far-end intima-media regions of the common carotid artery in ultrasound images. The method requires minimal user interaction and is able to segment the near-end wall in arteries with large, hypoechogenic and irregular plaques, issues usually not considered previously due to the increased segmentation difficulty. 相似文献
105.
Autonomous robots are leaving the laboratories to master new outdoor applications, and walking robots in particular have already shown their potential advantages in these environments, especially on a natural terrain. Gait generation is the key to success in the negotiation of natural terrain with legged robots; however, most of the algorithms devised for hexapods have been tested under laboratory conditions. This paper presents the development of crab and turning gaits for hexapod robots on a natural terrain characterized by containing uneven ground and forbidden zones. The gaits we have developed rely on two empirical rules that derive three control modules that have been tested both under simulation and by experiment. The geometrical model of the SILO-6 walking robot has been used for simulation purposes, while the real SILO-6 walking robot has been used in the experiments. This robot was built as a mobile platform for a sensory system to detect and locate antipersonnel landmines in humanitarian demining missions. 相似文献
106.
Orsi M.J. Santos J.R. 《IEEE transactions on systems, man, and cybernetics. Part A, Systems and humans : a publication of the IEEE Systems, Man, and Cybernetics Society》2010,40(1):100-106
This paper introduces a methodology to extend the capabilities of the dynamic inoperability input-output model (DIIM) to account for perturbations to sectors of the economy that are time varying and probabilistic. The DIIM accounts for the interdependent nature of the economy in determining the impact of a disruption on the ability of each economic sector to satisfy the prevailing demand. While the original formulation of the DIIM only allows for a single perturbation vector, this paper extends the DIIM to allow a perturbation matrix to be utilized as inputs to the model. The underlying motivation for this paper is understanding the impact of a pandemic on a regional economy. As such, idiosyncrasies associated with a pandemic are also accounted for in the model formulation. These include translating workforce absenteeism into a measure of sector inoperability and accounting for the impact of long-term absenteeism on a sector's ability to deliver its as-planned production output. 相似文献
107.
Daniel F. Macedo Aldri L. dos Santos Luiz H.A. Correia José M. Nogueira Guy Pujolle 《Computer Networks》2010,54(17):2979-2990
Wireless networks can vary both the transmission power and modulation of links. Existing routing protocols do not take transmission power control (TPC) and modulation adaptation (also known as rate adaptation – RA) into account at the same time, even though the performance of wireless networks can be significantly improved when routing algorithms use link characteristics to build their routes. This article proposes and evaluates extensions to routing protocols to cope with TPC and RA. The enhancements can be applied to any link state or distance vector routing protocols. An evaluation considering node density, node mobility and link error show that TPC- and RA-aware routing algorithms improve the average latency and the end-to-end throughput, while consuming less energy than traditional protocols. 相似文献
108.
109.
Adelmo L. Cechin José V. Canto dos Santos Carlos A. Mendel Arthur T. Gómez 《Engineering with Computers》2009,25(3):261-268
This study reports the use of a Genetic Algorithm (GA) to solve the Power System Restoration Planning Problem (PSRP). The
solution to the PSRP is described by a series of operations or a plan to be used by the Power System operator immediately
on the occurrence of a blackout in the electrical power supply. Our GA uses new initialization and crossover operators based
on the electrical power network, which are able to generate and maintain the plans feasible along GA runs. This releases the
Power Flow program, which represents the most computer demanding component, from computing the fitness function of unfeasible
individuals. The method was designed for large transmission systems and results for three different electrical power networks
are shown: IEEE 14-Bus, IEEE 30-Bus, and a large realistic system. 相似文献
110.
João André Cristina Santos Lino Costa 《Journal of Intelligent and Robotic Systems》2016,82(3-4):379-397
Robots must be able to adapt their motor behavior to unexpected situations in order to safely move among humans. A necessary step is to be able to predict failures, which result in behavior abnormalities and may cause irrecoverable damage to the robot and its surroundings, i.e. humans. In this paper we build a predictive model of sensor traces that enables early failure detection by means of a skill memory. Specifically, we propose an architecture based on a biped locomotion solution with improved robustness due to sensory feedback, and extend the concept of Associative Skill Memories (ASM) to periodic movements by introducing several mechanisms into the training workflow, such as linear interpolation and regression into a Dynamical Motion Primitive (DMP) system such that representation becomes time invariant and easily parameterizable. The failure detection mechanism applies statistical tests to determine the optimal operating conditions. Both training and failure testing were conducted on a DARwIn-OP inside a simulation environment to assess and validate the failure detection system proposed. Results show that the system performance in terms of the compromise between sensitivity and specificity is similar with and without the proposed mechanism, while achieving a significant data size reduction due to the periodic approach taken. 相似文献