User consent modeling for ensuring transparency and compliance in smart cities

Smart city infrastructures such as transportation and energy networks are evolving into so-called cyber physical social systems (CPSSs), which collect and     

Interactive Indirect Illumination Using Voxel Cone Tracing

Indirect illumination is an important element for realistic image synthesis, but its computation is expensive and highly dependent on the complexity of the scene and of the BRDF of the involved surfaces. While off‐line computation and pre‐baking can be acceptable for some cases, many applications (games, simulators, etc.) require real‐time or interactive approaches to evaluate indirect illumination. We present a novel algorithm to compute indirect lighting in real‐time that avoids costly precomputation steps and is not restricted to low‐frequency illumination. It is based on a hierarchical voxel octree representation generated and updated on the fly from a regular scene mesh coupled with an approximate voxel cone tracing that allows for a fast estimation of the visibility and incoming energy. Our approach can manage two light bounces for both Lambertian and glossy materials at interactive framerates (25–70FPS). It exhibits an almost scene‐independent performance and can handle complex scenes with dynamic content thanks to an interactive octree‐voxelization scheme. In addition, we demonstrate that our voxel cone tracing can be used to efficiently estimate Ambient Occlusion.     

Influence of Tension-Compression Asymmetry on the Mechanical Behavior of AZ31B Magnesium Alloy Sheets in Bending

Magnesium alloys are promising materials for lightweight design in the automotive industry due to their high strength-to-mass ratio. This study aims to study the influence of tension-compression asymmetry on the radius of curvature and energy absorption capacity of AZ31B-O magnesium alloy sheets in bending. The mechanical properties were characterized using tension, compression, and three-point bending tests. The material exhibits significant tension-compression asymmetry in terms of strength and strain hardening rate due to extension twinning in compression. The compressive yield strength is much lower than the tensile yield strength, while the strain hardening rate is much higher in compression. Furthermore, the tension-compression asymmetry in terms of r value (Lankford value) was also observed. The r value in tension is much higher than that in compression. The bending results indicate that the AZ31B-O sheet can outperform steel and aluminum sheets in terms of specific energy absorption in bending mainly due to its low density. In addition, the AZ31B-O sheet was deformed with a larger radius of curvature than the steel and aluminum sheets, which brings a benefit to energy absorption capacity. Finally, finite element simulation for three-point bending was performed using LS-DYNA and the results confirmed that the larger radius of curvature of a magnesium specimen is mainly attributed to the high strain hardening rate in compression.     

A Structure-Activity Relationship Study of Bimodal BODIPY-Labeled PSMA-Targeting Bioconjugates

The aim of this study was to identify a high-affinity BODIPY peptidomimetic that targets the prostate-specific membrane antigen (PSMA) as a potential bimodal imaging probe for prostate cancer. For the structure-activity study, several BODIPY (difluoroboron dipyrromethene) derivatives with varying spacers between the BODIPY dye and the PSMA Glu-CO-Lys binding motif were prepared. Corresponding affinities were determined by competitive binding assays in PSMA-positive LNCaP cells. One compound was identified with comparable affinity (IC₅₀=21.5±0.1 nM) to Glu-CO-Lys-Ahx-HBED-CC (PSMA-11) (IC₅₀=18.4±0.2 nM). Radiolabeling was achieved by Lewis-acid-mediated ¹⁹F/¹⁸F exchange in moderate molar activities (∼0.7 MBq nmol⁻¹) and high radiochemical purities (>99 %) with mean radiochemical yields of 20–30 %. Cell internalization of the ¹⁸F-labeled high-affinity conjugate was demonstrated in LNCaP cells showing gradual increasing PSMA-mediated internalization over time. By fluorescence microscopy, localization of the high-affinity BODIPY-PSMA conjugate was found in the cell membrane at early time points and also in subcellular compartments at later time points. In summary, a high-affinity BODIPY-PSMA conjugate has been identified as a suitable candidate for the development of PSMA-specific dual-imaging agents.     

2‐Aminopyridines as an α‐Bromination Shuttle in a Transition Metal‐Free One‐Pot Synthesis of Imidazo[1,2‐a]pyridines

A wide range of imidazo[1,2‐a]pyridines are accessible from cheap and readily available 2‐aminopyridines and 1,3‐dicarbonyl compounds using a unique CBrCl₃/2‐aminopyridine system for bromination at the α‐carbon. 2‐Aminopyridine is not only the substrate but also acts as a bromination shuttle, transferring the bromine atom from CBrCl₃ to the α‐carbon of the 1,3‐dicarbonyl. The reaction mechanism involves a series of reversible steps, including an addition reaction with cyclic transition state, to form a bromo‐hemiaminal intermediate. Isolated yields of up to 97% were obtained under mild conditions and at short reaction times in this transition metal‐free, one‐pot synthesis.

     

Efficient climate policies under technology and climate uncertainty

This article explores efficient climate policies in terms of investment streams into fossil and renewable energy technologies. The investment decisions maximise social welfare while observing a probabilistic guardrail for global mean temperature rise under uncertain technology and climate parameters. Such a guardrail constitutes a chance constraint, and the resulting optimisation problem is an instance of chance constrained programming, not stochastic programming as often employed. Our analysis of a model of economic growth and endogenous technological change, MIND, suggests that stringent mitigation strategies cannot guarantee a very high probability of limiting warming to 2 °C since preindustrial time under current uncertainty about climate sensitivity and climate response time scale. Achieving the 2 °C temperature target with a probability P? of 75% requires drastic carbon dioxide emission cuts. This holds true even though we have assumed an aggressive mitigation policy on other greenhouse gases from, e.g., the agricultural sector. The emission cuts are deeper than estimated from a deterministic calculation with climate sensitivity fixed at the P? quantile of its marginal probability distribution (3.6 °C). We show that earlier and cumulatively larger investments into the renewable sector are triggered by including uncertainty in the technology and climate response time scale parameters. This comes at an additional GWP loss of 0.3%, resulting in a total loss of 0.8% GWP for observing the chance constraint. We obtained those results with a new numerical scheme to implement constrained welfare optimisation under uncertainty as a chance constrained programming problem in standard optimisation software such as GAMS. The scheme is able to incorporate multivariate non-factorial probability measures such as given by the joint distribution of climate sensitivity and response time. We demonstrate the scheme for the case of a four-dimensional parameter space capturing uncertainty about climate and technology.     

Film and penetration theories for a first-order reaction in exothermic gas absorption

Film and penetration models for simultaneous heat and mass transfer are developed for the absorption of gas with a first-order chemical reaction in the liquid phase with temperature-dependent solubility and reaction rate coefficient. These two models represent two extreme conditions of interfacial temperature rise and gas solubility and they are compared with some previous models (Allan and Mann, 1979; Asai et al., 1985). The approximate analytical expressions of the penetration model of Asai et al. (1985) are in good agreement with the numerical results of this work. The results reveal that under many practical circumstances the gas-liquid interfacial temperature may be several degrees Kelvin higher than the bulk liquid temperature. The degree of deviation of the enhancement factor from its isothermal value at the bulk liquid temperature depends on the degree of difference of a certain dimensionless activation energy group from zero, which confirms the previous finding of Asai et al. (1985).     

Cobalt(II)‐Catalyzed Electrophilic Alkynylation of 1,3‐Dicarbonyl Compounds To Form Polysubstituted Furans via π–π Activation

Polysubstituted furans were obtained with excellent yields via the electrophilic alkynylation of 1,3‐dicarbonyl compoundsws with phenyl‐ or ester‐substituted brominated alkynes. The reaction is catalyzed by the inexpensive and readily available catalyst, cobalt(II) chloride, and has a wide substrate scope. The C(sp) C(sp³) coupling occurs under mild conditions with short reaction times and does not require an inert atmosphere or ligands. It is proposed that the reaction proceeds through a chelation complex of cobalt(II) with the deprotonated 1,3‐dicarbonyl compound.