Review of Dendritic Cells,Their Role in Clinical Immunology,and Distribution in Various Animal Species

Dendritic cells (DCs) are cells derived from the hematopoietic stem cells (HSCs) of the bone marrow and form a widely distributed cellular system throughout the body. They are the most efficient, potent, and professional antigen-presenting cells (APCs) of the immune system, inducing and dispersing a primary immune response by the activation of naïve T-cells, and playing an important role in the induction and maintenance of immune tolerance under homeostatic conditions. Thus, this review has elucidated the general aspects of DCs as well as the current dynamic perspectives and distribution of DCs in humans and in various species of animals that includes mouse, rat, birds, dog, cat, horse, cattle, sheep, pig, and non-human primates. Besides the role that DCs play in immune response, they also play a pathogenic role in many diseases, thus becoming a target in disease prevention and treatment. In addition, its roles in clinical immunology have also been addressed, which include its involvement in transplantation, autoimmune disease, viral infections, cancer, and as a vaccine target. Therefore, based on the current knowledge and understanding of the important roles they play, DCs can be used in the future as a powerful tool for manipulating the immune system.     

Fatigue damage in composite cylinders

In this study, optimal angle‐ply orientation of symmetric composite cylinders under fatigue loading is investigated. The fiber‐reinforced plastic cylinders were manufactured from E‐glass/epoxy. The layers were manufactured symmetrically in [±75°]₂, [±60°]₂, [±55°]₂, and [±45°]₂ orientations. Burst pressure of filament‐wound composite cylinders under alternating pure internal pressure was measured experimentally. Internal fatigue pressure testing method was applied to the composite cylinders in close‐ended condition. For this study, a PLC controlled hydraulic pressure testing machine has been employed. The static burst pressure values of specimens were measured; subsequently, fatigue test pressure was applied in 70, 60, and 50% stress levels of burst pressure for each orientation. Damage propagations of the composite cylinders on these stress levels were observed as whitening, leakage, and final failure for [±60°]₂, [±55°]₂, and orientations. When the damage propagation of [±75°]₂ angle‐ply cylinder was observed, whitening and leakage did not occur and final failure occurred suddenly. Stress‐cycle curves obtained from the tests are given in graphics. Experimental results reveal that variation in stress levels and the winding angles have considerable effects on final failure cycles, which is also presented graphically. The optimum winding angle for the composite pressure cylinders or vessels under internal fatigue pressure load was obtained as [±45°]₂ orientation. POLYM. COMPOS., 2010. © 2009 Society of Plastics Engineers     

A review on energy scenario and sustainable energy in Indonesia

The global energy consumption is likely to grow faster than the population growth. The fuel consumption was growing from 6630 million tons of oil equivalents (Mtoe) in 1980 to 11,163 Mtoe in 2009. This projected consumption will increase 1.5% per year until 2030 and reach 16,900 Mtoe and the main drivers of this growth are mostly developing countries in Asia. Indonesia is one of the developing countries and energy supply is an important factor for all-around development. The country's energy consumption still depends on non-renewable energy such as crude oil, coal and natural gas as sources of energy. Utilization of fossil fuel continuously contributes to huge amount of greenhouse gases emission that leads to climate change. Facing such an unfavorable situation, the government of Indonesia prioritizes on energy supply securities by diversification of energy resources. The energy mixes in Indonesia based on five main resources; these are crude oil, natural gas, coal, hydropower, and renewable energy. Although the country encourages utilizing renewable energy, the contribution is only around 3%. Considering natural condition and geography, this country is blessed with great potential of renewable energy such as solar energy, wind energy, micro hydro and biomass energy. Noting the potential of renewable and sustainable energy resources in the country, the government must pay more attention on how to utilize it. Many efforts have been done to promote renewable energy such as to create energy policy and regulations, yet it still did not give any satisfactory result. Government, non-government agencies and the public should take a more proactive step to promote and use renewable energy in order to achieve the secure and environmentally sustainable energy resources.     

Effects of Growth Rates and Compositions on Dendrite Arm Spacings in Directionally Solidified Al-Zn Alloys

Dendritic spacing can affect microsegregation profiles and also the formation of secondary phases within interdendritic regions, which influences the mechanical properties of cast structures. To understand dendritic spacings, it is important to understand the effects of growth rate and composition on primary dendrite arm spacing (λ ₁) and secondary dendrite arm spacing (λ ₂). In this study, aluminum alloys with concentrations of (1, 3, and 5 wt pct) Zn were directionally solidified upwards using a Bridgman-type directional solidification apparatus under a constant temperature gradient (10.3 K/mm), resulting in a wide range of growth rates (8.3–165.0 μm/s). Microstructural parameters, λ ₁ and λ ₂ were measured and expressed as functions of growth rate and composition using a linear regression analysis method. The values of λ ₁ and λ ₂ decreased with increasing growth rates. However, the values of λ ₁ increased with increasing concentration of Zn in the Al-Zn alloy, but the values of λ ₂ decreased systematically with an increased Zn concentration. In addition, a transition from a cellular to a dendritic structure was observed at a relatively low growth rate (16.5 μm/s) in this study of binary alloys. The experimental results were compared with predictive theoretical models as well as experimental works for dendritic spacing.     

Microstructure and Hardness Properties Investigation of Ti and Nb Added FeNiAlCuCrTi x Nb y High Entropy Alloys

Properties of pure metals can be enhanced by alloying with other metallic or non-metallic elements according to the need. However, as multiple alloying elements in an alloy may lead to the formation of many intermetallic compounds with complex microstructures and poor mechanical properties, new types of metallic alloys called high entropy alloys with at least five elements with equimolar ratios were developed. In this study, FeNiAlCuCrTi _x Nb _y (x, y = 0, 0.5, 1.0, 1.5) alloys have been prepared using Ar arc melting technique. Microstructural studies using scanning electron microscope and XRD showed that Ti addition promoted secondary BCC₂ phase whereas, Nb acted as FCC stabilizer. Samples with combined Nb and Ti addition showed FCC₁ and FCC₂ structure with Nb-rich FCC₂ dendritic phase as dominant phase. Though, individual Nb and Ti additions have resulted in increased hardness, combined additions have resulted in highest hardness of 797 HV under 1 kg load.     

Polystyrene Attached Pt(IV)�CAzomethine, Synthesis and Immobilization of Glucose Oxidase Enzyme

Modified polystyrene with Pt(IV)–azomethine (APS–Sch–Pt) was synthesized by means of condensation and demonstrated to be a promising enzyme support by studying the enzymatic properties of glucose oxidase enzyme (GOx) immobilized on it. The characteristics of the immobilized glucose oxidase (APS–Sch–Pt–GOx) enzyme showed two optimum pH values that were pH = 4.0 and pH = 7. The insertion of stable Pt(IV)–azomethine spacers between the polystyrene backbone and the immobilized GOx, (APS–Sch–Pt–GOx), increases the enzymes’ activity and improves their affinity towards the substrate even at pH = 4. The influence of temperature, reusability and storage capacity on the free and immobilized glucose oxidase enzyme was investigated. The storage stability of the immobilized glucose oxidase was shown to be eleven months in dry conditions at +4 °C.     

Insight into the rescue of oxidized soluble guanylate cyclase by the activator cinaciguat

Nitric oxide (NO) signaling mediates many important physiological processes through the receptor soluble guanylate cyclase (sGC). Under disease conditions sGC heme can be oxidized resulting in NO insensitivity. Here, we show that the therapeutic compound cinaciguat (Cin) rescues dysfunctional sGC by direct displacement of the oxidized heme.