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排序方式: 共有817条查询结果,搜索用时 46 毫秒
131.
Production of wheat gluten hydrolysates with reduced antigenicity employing enzymatic hydrolysis combined with downstream unit operations
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132.
Long‐chain monounsaturated fatty acid‐rich fish oil attenuates the development of atherosclerosis in mouse models
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Zhi‐Hong Yang Toshihiro Sakurai Ye Chen Beatrice Emma‐Okon Bree Wilhite Daiju Fukuda Boris Vaisman Milton Pryor Yoshiyuki Wakabayashi Maureen Sampson Zu‐Xi Yu Akiko Sakurai Abdalrahman Zarzour Hiroko Miyahara Jiro Takeo Hiroshi Sakaue Masataka Sata Alan T. Remaley 《Molecular nutrition & food research》2016,60(10):2208-2218
133.
Asymmetric phospholipid: lipopolysaccharide bilayers; a Gram-negative bacterial outer membrane mimic
Luke A. Clifton Maximilian W. A. Skoda Emma L. Daulton Arwel V. Hughes Anton P. Le Brun Jeremy H. Lakey Stephen A. Holt 《Journal of the Royal Society Interface》2013,10(89)
The Gram-negative bacterial outer membrane (OM) is a complex and highly asymmetric biological barrier but the small size of bacteria has hindered advances in in vivo examination of membrane dynamics. Thus, model OMs, amenable to physical study, are important sources of data. Here, we present data from asymmetric bilayers which emulate the OM and are formed by a simple two-step approach. The bilayers were deposited on an SiO2 surface by Langmuir–Blodgett deposition of phosphatidylcholine as the inner leaflet and, via Langmuir–Schaefer deposition, an outer leaflet of either Lipid A or Escherichia coli rough lipopolysaccharides (LPS). The membranes were examined using neutron reflectometry (NR) to examine the coverage and mixing of lipids between the bilayer leaflets. NR data showed that in all cases, the initial deposition asymmetry was mostly maintained for more than 16 h. This stability enabled the sizes of the headgroups and bilayer roughness of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine and Lipid A, Rc-LPS and Ra-LPS to be clearly resolved. The results show that rough LPS can be manipulated like phospholipids and used to fabricate advanced asymmetric bacterial membrane models using well-known bilayer deposition techniques. Such models will enable OM dynamics and interactions to be studied under in vivo-like conditions. 相似文献
134.
In the face of increasing supply base complexity, organisations have to develop new ways to manage or mitigate risk. This paper investigates the impact of four dimensions of complexity on the frequency of disruptions and plant performance. We apply insights from organisational information processing theory to understand how organisations can mitigate against the impact of more frequent disruptions. We test the moderating effects of slack resources as a means to absorb the effects of disruptions and supply visibility as a means to improve the ability to handle disruptions. The model is tested with data from 264 supply chain management professionals. Our findings broadly support the original hypotheses and suggest that supply base complexity can increase the frequency of disruptions and reduce plant performance but that slack resources and visibility can help to mitigate the effects. The study offers valuable insights into the management of supply base complexity. 相似文献
135.
Schönrogge K Napper EK Birkett MA Woodcock CM Pickett JA Wadhams LJ Thomas JA 《Journal of chemical ecology》2008,34(2):168-178
The larva of the hoverfly Microdon mutabilis is a specialist social parasite of the ant Formica lemani that is adapted to local groups of F. lemani colonies but mal-adapted to colonies of the same species situated only a few hundred meters away. At a study site in Ireland,
F. lemani shares its habitat with four other ant species. All nest under stones, making the oviposition choice by M. mutabilis females crucial to offspring survival. In this study, we tested the hypothesis that, as an extreme specialist, M. mutabilis should respond to cues derived from its host rather than from its microenvironment, a phenomenon that has hitherto only been
addressed in the context of herbivorous insects and their parasitoids. In behavioral assays, M. mutabilis females reacted to volatiles from F. lemani colonies by extending their ovipositors, presumably probing for an oviposition substrate. This behavior was not observed
toward negative controls or volatiles from colonies of Myrmica scabrinodis, the host ant of the closely related Microdon myrmicae. Coupled gas chromatography-electroantennography (GC-EAG) that used antennal preparations of M. mutabilis located a single physiologically active compound within an extract of heads of F. lemani workers. Coupled GC-mass spectrometry (GC-MS) tentatively identified the compound as a methylated methylsalicylate. GC co-injection
of the extract with authentic samples showed that of the four possible isomers (methyl 3-, 4-, 5-, and 6-methylsalicylate),
only methyl 6-methylsalicylate co-eluted with the EAG-active peak. Furthermore, the response to methyl 6-methylsalicylate
was four times higher than to those of the other isomers. Coupled GC-EAG and GC-MS also revealed physiological responses to
two constituents, 3-octanone and 3-octanol, of the M. scabrinodis alarm pheromone. However, the behavioral trials did not reveal any behavior that could be attributed to these compounds.
Results are discussed in the context of four phases of host location behavior, and of the characteristics, which volatile
cues should provide to be useful for an extreme specialist such as M. mutabilis. 相似文献
136.
Emma Söderhjelm Matthew P. House Neil Cruise Johan Holmberg Michael Bowker Jan-Olov Bovin Arne Andersson 《Topics in Catalysis》2008,50(1-4):145-155
Methanol oxidation to formaldehyde was studied over a series of Fe–Mo–O catalysts with various Mo/Fe atomic ratio and the end compositions Fe2O3 and MoO3. The activity data show that the specific activity passes through a maximum with increase of the Mo content and is the highest for Fe2(MoO4)3. The selectivity to formaldehyde, on the other hand, increases with the Mo content in the catalyst. A synergy effect is observed in that a catalyst with the Mo/Fe ratio 2.2 is almost as active as Fe2(MoO4)3 and as selective as MoO3. Imaging of a MoO3/Fe2(MoO4)3 catalyst by SEM and TEM shows that the two phases form separate crystals, and HRTEM reveals the presence of an amorphous overlayer on the Fe2(MoO4)3 crystals. EDS line-scan analysis in STEM mode demonstrates that the Mo/Fe ratio in the amorphous layer is ~2.1 in the fresh catalyst and ~1.7 in the aged catalyst. The enrichment of Mo at the catalyst surface is confirmed by XPS data. Raman spectra give evidence for the Mo in the amorphous material being in octahedral coordination, which is in contrast to the crystalline Fe2(MoO4)3 bulk structure where Mo has tetrahedral coordination. X-ray diffraction (XRD) analysis gives no support for the formation of a defective molybdate bulk structure. The results presented give strong support for the Mo rich amorphous structure being observed on the Fe2(MoO4)3 crystal surfaces being the active phase for methanol oxidation to formaldehyde. 相似文献
137.
Emma Hendry Barbara Conway Tony Worthington 《International journal of molecular sciences》2012,13(11):14016-14025
Effective surface disinfection is a fundamental infection control strategy within healthcare. This study assessed the antimicrobial efficacy of novel biocide formulations comprising 5% and 2% eucalyptus oil (EO) combined with 2% chlorhexidine digluconate (CHG) and 70% isopropyl alcohol (IPA) contained within a wipe. The efficacy of this novel antimicrobial formulation to remove and eliminate methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Candida albicans from steel surfaces was investigated. Adpression studies of pre-contaminated wipes were also utilised to assess their potential to induce cross-contamination between hard surfaces. Furthermore, the bactericidal nature of the EO-formulation was established in addition to time-kill. The EO-containing formulations demonstrated bactericidal antimicrobial efficacy against all microorganisms and did not induce surface cross-contamination. There was no significant difference (p < 0.05) between the 5% and 2% EO formulations in their ability to remove microorganisms from steel surfaces, however both significantly (p < 0.05) removed more than the control formulations. Microbial biofilms were eliminated within 10 min (p < 0.05) when exposed to the EO formulations. Our novel EO-formulation demonstrated rapid antimicrobial efficacy for potential disinfection and elimination of microbial biofilms from hard surfaces and may therefore be a useful adjunct to current infection control strategies currently employed within healthcare facilities. 相似文献
138.
Comparison of coagulation performance and floc properties using a novel zirconium coagulant against traditional ferric and alum coagulants 总被引:2,自引:0,他引:2
Coagulation in drinking water treatment has relied upon iron (Fe) and aluminium (Al) salts throughout the last century to provide the bulk removal of contaminants from source waters containing natural organic matter (NOM). However, there is now a need for improved treatment of these waters as their quality deteriorates and water quality standards become more difficult to achieve. Alternative coagulant chemicals offer a simple and inexpensive way of doing this. In this work a novel zirconium (Zr) coagulant was compared against traditional Fe and Al coagulants. The Zr coagulant was able to provide between 46 and 150% lower dissolved organic carbon (DOC) residual in comparison to the best traditional coagulant (Fe). In addition floc properties were significantly improved with larger and stronger flocs forming when the Zr coagulant was used with the median floc sizes being 930 μm for Zr; 710 μm for Fe and 450 μm for Al. In pilot scale experiments, a similar improved NOM and particle removal was observed. The results show that when optimised for combined DOC removal and low residual turbidity, the Zr coagulant out-performed the other coagulants tested at both bench and pilot scale. 相似文献
139.
Pfannkuchen M Godrijan J Pfannkuchen DM Iveša L Kružić P Ciminiello P Dell'Aversano C Dello Iacovo E Fattorusso E Forino M Tartaglione L Godrijan M 《Environmental science & technology》2012,46(10):5574-5582
Mass appearances of the toxic dinoflagellate genus Ostreopsis are known to cause dangerous respiratory symptoms in humans exposed to aerosols. The outbreaks can appear in shallow marine waters of temperate regions around the globe. We followed a massive bloom event on a public beach on the northern Adriatic coast near Rovinj, Croatia. We identified the responsible species and the produced toxins as well as the dynamics of the event with respect to environmental conditions. Ostreopsis cf. ovata appeared in masses from September through October 2010 on a public beach near Rovinj, Croatia but stayed undetected by public health organizations. Respiratory symptoms were observed whenever humans were exposed to substrate samples containing large numbers of Ostreopsis cells. During the mass abundance of O. cf. ovata also exposure to the aerosols on the beach evoked respiratory symptoms in humans. Our measurements showed high cell abundances and high toxin contents with a stable relative contribution of putative Palytoxin and Ovatoxins a-e. Artificial beach structures proved to dramatically reduce settling of the observed Ostreopsis biofilm. Blooms like those reported herein have a high potential to happen undetected with a high potential of affecting the health of coastal human populations. Increased monitoring efforts are therefore required to understand the ecology and toxicology of those bloom events and reduce their negative impact on coastal populations. 相似文献
140.
Emma C. Stephens Charles F. Nicholson Douglas R. Brown David Parsons Christopher B. Barrett Johannes Lehmann David Mbugua Solomon Ngoze Alice N. Pell Susan J. Riha 《Food Security》2012,4(3):423-439
We investigate the interactions between natural resource-based poverty traps and food security for smallholder farms in highland Kenya using a recently developed system dynamics bio-economic model. This approach permits examination of the complex interactions and feedback between farm household economic decision-making and long-term soil fertility dynamics that characterize persistent poverty and food insecurity among smallholders in rural highland Kenya. We examine the effects of changing initial endowments of land and stocks of soil organic matter on smallholders?? well being, as reflected in several different indicators. We show that larger and higher quality land endowments permit accumulation of cash and livestock resources and conservation of soil organic matter relative to smaller or more degraded farms. This suggests the existence of asset thresholds that divide food secure households from food insecure ones. 相似文献