Optimization Methods for Post-Bond Testing of 3D Stacked ICs

Testing of three-dimensional (3D) stacked ICs (SICs) is starting to receive considerable attention in the semiconductor industry. Since the die-stacking steps of thinning, alignment, and bonding can introduce defects, there may be a need to test multiple subsequent partial stacks during 3D assembly. We address the problem of test-architecture optimization for 3D stacked ICs to minimize overall test time when either the complete stack only, or the complete stack and multiple partial stacks, need to be tested. A general solution to this problem provides several options for 3D stack testing in a unified framework. We show that optimal test-architecture solutions and test schedules for multiple test insertions are different from their counterparts for a single final stack test. In addition, we present optimization techniques for the testing of TSVs and die-external logic in combination with the dies in the stack.     

Renoprotective Angiographic Polymersomes

Computed tomography (CT) angiography is powerful for the diagnosis of vascular diseases. Unfortunately, this method usually requires a high dosage of iodinated contrast agents, which can lead to severe elevation of reactive oxygen species (ROS) levels within kidneys. This causes oxidative stress, apoptosis, and hence contrast-induced nephropathy (CIN), a leading cause of iatrogenic renal failure, especially for patients with renal insufficiency. Herein, a route is shown to circumvent such problems with the usage of rationally designed renoprotective angiographic polymersomes (RAPs) as blood pool CT contrast agents. RAPs are biodegradable nanoparticles prepared via self-assembly of poly(ethylene oxide)-block-poly(triiodobenzoic chloride-conjugated polylysine-stat-phenylboronic acid pinacol ester-conjugated polylysine) (PEO₄₅-b-P[(Lys-IBC)₄₅-stat-(Lys-PAPE)₁₅]). The key to the efficiency of such nanoparticles as renoprotective contrast agents arises from the rationally chosen repeat units: Lys-IBC exhibits a concentration-dependent X-ray attenuation capability and Lys-PAPE introduces an ROS-scavenging ability to the polymersome. The study shows that RAPs can reduce the risk of CIN in mice with kidney injury. Additionally, a 5-fold increase in angiographic live time is observed using RAPs, compared to commonly used iodinated small molecule contrast agents. In summary, a new strategy is proposed for the design of a renoprotective angiographic contrast agent that is capable of reducing the risk of CIN.     

Spline-based cardiac motion tracking using velocity-encoded magnetic resonance imaging

This paper deals with the problem of tracking cardiac motion and deformation using velocity-encoded magnetic resonance imaging. We expand upon an earlier described method and fit a spatiotemporal motion model to measured velocity data. We investigate several different spatial elements both qualitatively and quantitatively using phantom measurements and data from human subjects. In addition, we also use optical flow estimation by the Horn–Schunk method as complementary data in regions where the velocity measurements are noisy. Our results show that it is possible to obtain good motion tracking accuracy in phantoms with relatively few spatial elements, if the type of element is properly chosen. The use of optical flow can correct some measurement artifacts but may give an underestimation of the magnitude of the deformation. In human subjects the different spatial elements perform quantitatively in a similar way but qualitative differences exists, as shown by a semiquantitative visual scoring of the different methods.      

Data Converter for Multistandard Mobile Phones

This paper describes an analog to digital converter (ADC) for mobile communication systems using a direct down conversion architecture. The ADC can be programmed to meet the requirements of different communication standards, including GSM (Global System for Mobile communication) and WCDMA (Wideband Code Division Multiple Access). The ADC is realized with a pipeline ADC architecture for WCDMA and a Sigma-Delta architecture for GSM. In order to have an optimized area and power consumption, the basic building blocks (opamps) of the converters are shared between the two converter architectures. The entire ADC consumes about 5.5 mW and occupies an active area of about 0.36 mm². A test circuit has been developed and fabricated and measurements show that both the required programmability and the required performance can be obtained using the proposed configurations.     

Biocompatibility of a lab-on-a-pill sensor in artificial gastrointestinal environments

In this paper, we present a radiotelemetry sensor, designed as a lab-in-a-pill, which incorporates a two-channel microfabricated sensor platform for real-time measurements of temperature and pH. These two parameters have potential application for use in remote biological sensing (for example they may be used as markers that reflect the physiological environment or as indicators for disease, within the gastrointestinal tract). We have investigated the effects of biofouling on these sensors, by exploring their response time and sensitivity in a model in vitro gastrointestinal system. The artificial gastric and intestinal solutions used represent a model both for fasting, as well as for the ingestion of food and subsequent digestion to gastrointestinal chyme. The results showed a decrease in pH sensitivity after exposure of the sensors for 3 h. The response time also increased from an initial measurement time of 10 s in pure GI juice, to ca. 25 s following the ingestion of food and 80 s in simulated chyme. These in vitro results indicate that changes in viscosity in our model gastrointestinal system had a pronounced effect on the unmodified sensor.     

Field test results of multi-channel digital tv transmission at 15 and 30 Mb/s through an intelsat satellite using a PSK/FDMA system

This paper describes field test results of multi-channel digital TV transmission using a PSK/FDMA system and the related subjective test results of received TV pictures. The picture quality of the multi-channel 15 or 30 Mb/s transmission for both NTSC and PAL systems through the INTELSAT POR satellite are subjectively evaluated for various bit-error rates. In addition, subjective evaluations were made at various values of earth-station e.i.r.p. to compare the picture quality of digital transmissions with that of current half-transponder FM transmission.     

Damage characterization of 3D braided composites using carbon nanotube-based in situ sensing

Carbon nanotubes (CNTs) were used as an in situ sensor to detect the initiation of micro-cracks and their accumulation in fiber-reinforced polymer composites. The breakage of the electrically conductive networks formed by CNTs throughout the polymer matrix when dispersed in composites enables the micro-cracks to be sensed. This methodology was applied to three-dimensional (3D) braided composites with the aim of investigating the feasibility of detecting their matrix failure and analyzing their damage behavior. Tensile specimens were prepared using 3D braided ultra-high molecular weight polyethylene (UHMWPE) preforms and vinyl ester containing multi-walled CNTs (0.5 wt%) via vacuum-assisted resin transfer molding (VARTM). The electrical resistance of the composites was then measured during tensile testing, while their internal structures were analyzed using X-ray computer tomography (CT), demonstrating that the CNTs dispersed in the matrix enable micro-cracks to be sensed and the damage modes of the 3D braided composites to be analyzed. Finally, four critical strain levels that can classify the damage modes were identified from the change of the electrical resistance of the 3D braided composites.     

MedISys: An early-warning system for the detection of (re-)emerging food- and feed-borne hazards

We evaluated the Medical Information System (MedISys) as an early-warning system for the detection of food- and feed-borne hazards. Nine hazards were selected in the period from January 2007 to March 2009 from the Rapid Alert System for Food and Feed (RASFF) and traced back on MedISys and ProMED-mail. In addition, from January to March 2009, food- and feed-borne (re-)emerging hazards were monitored on MedISys and traced back on ProMED-mail and RASFF. MedISys has demonstrated to be an effective early-warning system for food- and feed-borne hazards. However, further customization is required to improve its sensitivity, in particular by increasing the number of multi-lingual categories related to food and feed items. MedISys tended to detect food- and feed-borne hazards earlier and more frequently than ProMED-mail, but the information from both systems was often complementary.