Design of a framework for modeling, integration and simulation of physiological models

Multiscale modeling and integration of physiological models carry challenges due to the complex nature of physiological processes. High coupling within and among scales present a significant challenge in constructing and integrating multiscale physiological models. In order to deal with such challenges in a systematic way, there is a significant need for an information technology framework together with related analytical and computational tools that will facilitate integration of models and simulations of complex biological systems. Physiological Model Simulation, Integration and Modeling Framework (Phy-SIM) is an information technology framework providing the tools to facilitate development, integration and simulation of integrated models of human physiology. Phy-SIM brings software level solutions to the challenges raised by the complex nature of physiological systems. The aim of Phy-SIM, and this paper is to lay some foundation with the new approaches such as information flow and modular representation of the physiological models. The ultimate goal is to enhance the development of both the models and the integration approaches of multiscale physiological processes and thus this paper focuses on the design approaches that would achieve such a goal.     

Clustering based distributed phylogenetic tree construction

Phylogenetic tree construction has received much attention recently due to the availability of vast biological data. In this study, we provide a three step method to build phylogenetic trees. Firstly, a density-based clustering algorithm is used to provide clusters of the population at hand using the distance matrix which shows the distances of the species. Secondly, a phylogenetic tree for each cluster is constructed by using the neighbor-joining (NJ) algorithm and finally, the roots of the small phylogenetic trees are connected again by the NJ algorithm to form one large phylogenetic tree. To our knowledge, this is the first method for building phylogenetic trees that uses clustering prior to forming the tree. As such, it provides independent phylogenetic tree formation within each cluster as the second step, hence is suitable for parallel/distributed processing, enabling fast processing of very large biological data sets.The proposed method, clustered neighbor-joining (CNJ) is applied to 145 samples from the Y-DNA Haplogroup G. Distances between male samples are the variation in their set of Y-chromosomal short tandem repeat (STR) values. We show that the clustering method we use is superior to other clustering methods as applied to Y-DNA data and also independent, fast distributed construction of phylogenetic trees is possible with this method.     

Ti（1-x）CoxO2的溶胶-凝胶法制备与结构

采用溶胶-凝胶方法制备了Ti（1-x）CoxO2样品。研究了不同的热处理温度和掺杂浓度对样品晶型和颗粒尺寸的影响。样品400℃热处理呈锐钛矿相，600℃转变为全红石相并且晶粒尺寸明显增大。掺杂对晶型没有影响，但是随掺杂量的增大晶格常数减小。     

高性能混凝土配合比设计的试验研究

从对HPC组成、结构的认识出发，借鉴利用拨开系数求砂率的方法，提出了一种新的HPC配制方法，并通过试验证实该方法是完全可行的．     

无刷柴油发电机神经元双PSD控制

文中就无刷柴油发电机的两个输入量，设计了基于单个神经元的双PSD控制器，其智能控制方法简单，响应速度快，MATLAB仿真结果表明，这种控制器对于非线性被控系统具有良好的适应性和鲁棒性．     

虚拟现实技术及其在现代医学中的应用

虚拟现实是近年来发展起来的一项新的技术,它已经被广泛地应用于许多领域,特别是在医学领域．本文在简述虚拟现实技术的基础上,从虚拟人、辅助诊断和手术、虚拟手术模拟以及虚拟的远程医疗系统四个方面介绍了虚拟现实在医学上的应用．     

670 t/h锅炉燃烧系统改造

针对扬州发电有限公司200Mw机组4号炉(670t／h)长期存在锅炉灰渣可燃特含量偏高、锅炉效率偏低问题，在详细试验的基础上．对4号炉三次风燃烧系统进行了改造。改造后试验结果表明，4号炉在制粉系统运行条件下，锅炉效率提高2％以上。     

Successful adoption of macroergonomics in manufacturing: Using a multicriteria decision‐making methodology– analytic hierarchy process

The research presented in this paper aims to support the macroergonomics adoption improvement process by developing a broader understanding of relationships between key macroergonomics factors and management styles. The methodology involves knowledge acquisition, identifying, and categorizing a holistic set of key criteria about the macroergonomics adoption process. The Analytic Hierarchy Process is suggested as a multi‐attribute decision‐making methodology to effectively enhance adoption of macroergonomics and to improve management decision performance in measuring and comparing the overall performance of different management styles based on macroergonomical criteria. The study found that in terms of company culture, participation, human capability, and attitudes, the best management style in improving macroergonomics adoption is Management by Values. © 2004 Wiley Periodicals, Inc. Hum Factors Man 14: 353–377, 2004.