TLR/WNT: A Novel Relationship in Immunomodulation of Lung Cancer

The most frequent cause of death by cancer worldwide is lung cancer, and the 5-year survival rate is still very poor for patients with advanced stage. Understanding the crosstalk between the signaling pathways that are involved in disease, especially in metastasis, is crucial to developing new targeted therapies. Toll-like receptors (TLRs) are master regulators of the immune responses, and their dysregulation in lung cancer is linked to immune escape and promotes tumor malignancy by facilitating angiogenesis and proliferation. On the other hand, over-activation of the WNT signaling pathway has been reported in lung cancer and is also associated with tumor metastasis via induction of Epithelial-to-mesenchymal-transition (EMT)-like processes. An interaction between both TLRs and the WNT pathway was discovered recently as it was found that the TLR pathway can be activated by WNT ligands in the tumor microenvironment; however, the implications of such interactions in the context of lung cancer have not been discussed yet. Here, we offer an overview of the interaction of TLR-WNT in the lung and its potential implications and role in the oncogenic process.     

DATA ANALYSIS PRIOR TO A CIRCULATION MODEL IN GRAN CANARIA

The use of numerical models in physical oceanography, with the aim of reproducing and predicting water movements, is a common practice, especially for coastal areas. Nevertheless, results will be accurate only if the assumptions are appropriate and include all significant characteristics of the domain under modeling. Two-dimensional models are often used for shallow-water areas, but the implicit assumptions of conservation of a characteristic vertical profile for the horizontal velocities all over the domain and negligible vertical circulation must be exhaustively checked. Here a case is presented in which two-dimensionality would have led to inaccurate results, as the analysis of the field data showed a three-layer behavior. This case concerns the eastern coast of Gran Canaria island (Canary Islands) and illustrates how mathematical models will describe the phenomena they try to represent correctly only if all assumptions are right.