Quantitative trait loci for murine growth

Body size is an archetypal quantitative trait with variation due to the segregation of many gene loci, each of relatively minor effect, and the environment. We examine the effects of quantitative trait loci (QTLs) on age-specific body weights and growth in the F2 intercross of the LG/J and SM/J strains of inbred mice. Weekly weights (1-10 wk) and 75 microsatellite genotypes were obtained for 535 mice. Interval mapping was used to locate and measure the genotypic effects of QTLs on body weight and growth. QTL effects were detected on 16 of the 19 autosomes with several chromosomes carrying more than one QTL. The number of QTLs for age-specific weights varied from seven at 1 week to 17 at 10 wk. The QTLs were each of relatively minor, subequal effect. QTLs affecting early and late growth were generally distinct, mapping to different chromosomal locations indicating separate genetic and physiological systems for early and later murine growth.     

Massive ascites associated wth endometriosis

Massive ascites associated with pelvic endometriosis is an unusual occurrence. Two cases recently encountered by the authors are presented, and 7 additional cases from the literature are reviewed. Clinical courses and operative findings are described, and the management of the cases is presented. The etiology of ascites is explored and the possibility of conservative surgery and hormonal control with danazol is discussed.     

American cutaneous leishmaniasis in a military training center located in Zona da Mata, Pernambuco, Brazil

In a case of infantile mucolipidosis type II (I-cell disease), storage was identified at autopsy in serous-type secretory cells in exocrine pancreas, in the tracheal and sublingual salivary glands and in the chief (zymogenic) cells of the gastric oxyntic glands, suggesting a systemic involvement of this type of secretory cells. The content of specific secretory granules was inversely proportional to the intensity of the storage process. The mucus-producing cells were not affected. The serous glandular system is a novel storage site in I-cell disease. Review of archival material in three further cases confirmed the findings.     

夹具常用标准件参数化图库

介绍了应用VBA和Access2000开发建立AutoCAD环境下的夹具标准件图库的方法,并给出了部分原代码。     

浅液矩形TLD对地震作用下高层振动的控制

在研究TLD减振耗能机理的基础上，分别分析了TLD的主要设计参数，即频率比、深度比及质量比对控制效果的影响，由此给出了对TLD进行有效设计的主要步骤，说明了只要对TLD各参数合理调整，就可以很好地控制结构在地震作用下的响应。     

济钢3^#1750m^3高炉高产低耗冶炼实践

通过加强原燃料管理,控制合理的煤气流分布,强化日常操作管理以及使用高风温、高顶压、低富氧,降低生铁含硅偏差,改善炉渣性能等一系列措施,济钢3^#1750m^3高炉在保持平均利用系数2．5t／（m^3·d）的同时,综合焦比、吨铁返粉等指标不断降低,实现了高产低耗冶炼。     

月球表面微波主被动遥感的建模模拟与反演

探测月球和其它外星球是我国空间遥感与深空探测的又一轮新课题。研究地球遥感中星载被动遥感辐射计、主动遥感高分辨率合成孔径雷达等如何应用于月球和其它外星球的探测是一项十分有意义的工作。了解月球表层的月壤与月岩的物质状态及其分布,对于月球资源的科学认识、以及未来月球探测、登月与月球开发,以及其它外星球探测均具有十分重要的意义。先讨论微波被动遥感月球表面辐射的模拟和由微波辐射反演月壤厚度。由月球表面数字高程和月壤厚度实测点数据建立月球表面高度与月壤厚度的一种对应关系,构造整个月球表面月壤厚度的试验性分布。根据克莱门汀的紫外可见光光学数据,计算整个月球表面月壤中FeO+TiO2含量分布,给出整个月球表面月壤介电常数分布。由月球表层温度的观测结果以及月壤的导热特性,给出月尘层与月壤层温度随纬度分布的经验公式。在这些条件基础上,建立月尘、月壤、月岩3层微波热辐射模型。由起伏逸散定理,模拟计算月壤低耗散介质层多通道辐射亮度温度。以此辐射亮度温度模拟加随机噪声为理论观测值,按3层模型提出月壤层厚度反演方法。由于高频通道穿透深度小,由高频通道的辐射亮度温度按照两层尘-月壤微波热辐射模型反演月尘层与月壤层的物理温度。并以此为已知参数,由穿透深度较大的低频通道的辐射亮度温度反演月壤层厚度,对于反演的相对误差也进行了讨论。在研究微波主动遥感方面,提出低空飞行全极化L波段雷达窄脉冲探测月壤层厚与层结构的建议。此时采用一层具有上下随机粗糙界面的有耗 介质层月壤层模型,在下垫月岩粗糙界面上有一层随机分布的碎石散射体。推导了包含面散射、体散射,以及面体相互作用7种散射机制的全极化脉冲波Mueller矩阵解。以月壤特征参数(月壤层厚、FeO+TiO2金属含量、介电常数,界面粗糙度、碎石分布等)为函数,用时域Mueller矩阵解数值模拟来验证方法可行性。L波段窄脉冲极化回波波形能用于反演或估算月壤厚度与分层结构。     

Perianal Bowen's disease: associated tumors, human papillomavirus, surgery, and other controversies

BACKGROUND: Perianal Bowen's disease (BD) is an intraepithelial nonkeratinizing carcinoma, associated historically with internal tumors. METHODS: A review of patients with perianal BD presenting consecutively during a 25-year span was undertaken, excluding Bowenoid papulosis and contiguous genital BD. Histologic slides were resubmitted for review by an experienced pathologist, in a "blind" fashion among other slides. Follow-up was updated in every patient. Survival and recurrence curves were generated by the Kaplan-Meier method and were compared with a normal age-matched population (log-rank test). RESULTS: Nineteen patients were identified; 15 of them were females. Mean age +/- standard deviation was 49.6 +/- 10.6 years. Five patients had a coincidental diagnosis (hemorrhoidectomy or wart excision). No associated carcinomas were found; however, eight patients had isolated BD of the vulva. Eleven patients had a history of anal warts, cervical/vulvar dysplasia, or both. Wide resection, including V-Y flaps, was performed in 18 patients without dysfunction. One-year and five-year recurrence was 16 and 31 percent. Recurrence was treated in all but one case by wider resection. Mean follow-up was 8.4 years. Five-year survival was 75 percent, lower than the matched population (P = 0.001); however, only one death was related to BD. CONCLUSIONS: Perianal BD has no association with internal tumors. Despite a high rate of recurrence, perianal BD can be treated by local excision. An increased rate of human papilloma virus-related entities was found, which could suggest a causative role.     

Sulphidization flotation for recovery of lead and zinc from oxide-sulfide ores

A new flowsheet was developed to recover the valuable minerals from oxide or oxide-sulfide ores of lead and zinc. The flowsheet consisted of flotation of sulfide minerals, desliming and sulphidization-flotation of oxide minerals. The corresponding reagent system and techniques to the flowsheet were investigated. Batch and continuous tests show that the dosage of sodium sulfide, temperature, and collector type are main affecting factors on the recovery of smithsonite and cerussite. For the flotation of cerussite, there is an appropriate dosage of sodium sulfide at which the recovery reaches its maximum value. The required sodium sulfide for smithsonite flotation is higher than that for cerussite and the recovery of smithsonite flotation increases with the dosage of sodium sulfide at low level and becomes insensitive at high dosage. The appropriate temperature for smithsonite and cerussite flotation is found to be 25 ～ 40℃. Amines are found to be the effective collectors for the flotation of smithsonite after sulphidization. Investigation also shows that desliming prior to sulphidization-flotation is essential to the effective recovery of smithsonite and cerussite, and the desliming process of two-stage hydrocyclon is well feasible and effective for the treatment of lead-zinc oxide ores. A further treatment on the cerussite flotation concentrate by shaking table is proposed to obtain higher lead grade.     

The first report in Cuba of human intestinal infection by Cyclospora cayetanensis, Ortega, 1993

A trimeric enzyme chloramphenicol acetyltransferase (CATI) has been synthesized in the Zubay system genetically depleted from DnaK and DnaJ. Most of CAT formed in the system fail to assemble into an active trimer. Instead CAT is accumulated in either a GroEL-bound complex or as an inactive monomer. Addition of purified DnaK and DnaJ to the system prior to the start of protein synthesis leads to the increase of the specific activity of formed CAT. A portion of exogenous DnaK and DnaJ added to the system associate with nascent polypeptide chains in the ribosomes. DnaK also comigrates with 50S-ribosomal subunits.