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71.
Süleyman Karda Serkan elik Muhammed Ali Bingl Mehmet Sabir Kiraz Hüseyin Demirci Albert Levi 《Wireless Communications and Mobile Computing》2015,15(18):2150-2166
This paper examines Vaudenay's privacy model, which is one of the first and most complete privacy models that featured the notion of different privacy classes. We enhance this model by introducing two new generic adversary classes, k‐strong and k‐forward adversaries where the adversary is allowed to corrupt a tag at most k times. Moreover, we introduce an extended privacy definition that also covers all privacy classes of Vaudenay's model. In order to achieve highest privacy level, we study low cost primitives such as physically unclonable functions (PUFs). The common assumption of PUFs is that their physical structure is destroyed once tampered. This is an ideal assumption because the tamper resistance depends on the ability of the attacker and the quality of the PUF circuits. In this paper, we have weakened this assumption by introducing a new definition k‐resistant PUFs. k‐PUFs are tamper resistant against at most k attacks; that is, their physical structure remains still functional and correct until at most kth physical attack. Furthermore, we prove that strong privacy can be achieved without public‐key cryptography using k PUF‐based authentication. We finally prove that our extended proposal achieves both reader authentication and k‐strong privacy. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
72.
David L. Poerschke Gareth G. E. Seward Carlos G. Levi 《Journal of the American Ceramic Society》2016,99(2):651-659
This study investigated the influence of YbO1.5 concentration on the reactivity between YbO1.5–HfO2 thermal barrier coating (TBC) materials and silicate melts [calcium–magnesium aluminosilicate (CMAS), specifically 33CaO–9MgO–13AlO1.5–45SiO2, all in mol%]. Three thermal barrier oxides (TBO) with YbO1.5 concentration between 30 and 80 mol% were tested at 1300°C and 1500°C. Porous pellets were used to study reaction layer growth and the behavior within infiltrated porosity. Complementary experiments examined the phase equilibria in melts containing varying quantities of the candidate TBOs. The effectiveness of reactive crystallization to limit interaction depth increased with the YbO1.5 concentration in the TBO. The results indicate that the TBO must contain sufficient YbO1.5 to satisfy the equilibrium between the melt and HfO2‐based fluorite phase before YbO1.5‐bearing silicates can precipitate. Increasing the YbO1.5 availability leads to the crystallization of apatite, garnet, silicocarnotite, and/or cuspidine (alumino)silicates. Apatite was observed at 1300°C and 1500°C, garnet and silicocarnotite only appeared at 1300°C, and cuspidine was only evident at 1500°C. The implications for the design of CMAS‐resistant coatings are discussed in the context of the experimental results. 相似文献
73.
Production of lipid from depolymerised lignocellulose using the biocontrol yeast,Rhodotorula minuta: The fatty acid profile remains stable irrespective of environmental conditions 下载免费PDF全文
74.
Levi W. D. Mines Jae Hong Park Imali A. Mudunkotuwa T. Renée Anthony Vicki H. Grassian 《Aerosol science and technology》2016,50(5):497-506
Porous polyurethane foam was evaluated to replace the eight nylon meshes used as a substrate to collect nanoparticles in the Nanoparticle Respiratory Deposition (NRD) sampler. Cylindrical (25 mm diameter by 40 mm deep) foam with 100 pores per inch was housed in a 25-mm-diameter conductive polypropylene cassette cowl compatible with the NRD sampler. Pristine foam and nylon meshes were evaluated for metals content via elemental analysis. The size-selective collection efficiency of the foam was evaluated using salt (NaCl) and metal fume aerosols in independent tests. Collection efficiencies were compared to the nanoparticulate matter (NPM) criterion and a semi-empirical model for foam. Changes in collection efficiency and pressure drop of the foam and nylon meshes were measured after loading with metal fume particles as measures of substrate performance. Substantially less titanium was found in the foam (0.173 µg sampler?1) compared to the nylon mesh (125 µg sampler?1), improving the detection capabilities of the NRD sampler for titanium dioxide particles. The foam collection efficiency was similar to that of the nylon meshes and the NPM criterion (R2 = 0.98, for NaCl), although the semi-empirical model underestimated the experimental efficiency (R2 = 0.38). The pressure drop across the foam was 8% that of the nylon meshes when pristine and changed minimally with metal fume loading (~19 mg). In contrast, the pores of the nylon meshes clogged after loading with ~1 mg metal fume. These results indicate that foam is a suitable substrate to collect metal (except for cadmium) nanoparticles in the NRD sampler. Copyright © 2016 American Association for Aerosol Research 相似文献
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77.
Jeremy A. Nestele Anne-Katrin Rohlfing Valerie Dicenta Alexander Bild Daniela Eißler Frederic Emschermann Marcel Kremser Konstantin Krutzke Tilman E. Schffer Oliver Borst Moran Levi Netanel Korin Meinrad Paul Gawaz 《International journal of molecular sciences》2022,23(1)
Traditional antithrombotic agents commonly share a therapy-limiting side effect, as they increase the overall systemic bleeding risk. A novel approach for targeted antithrombotic therapy is nanoparticles. In other therapeutic fields, nanoparticles have enabled site-specific delivery with low levels of toxicity and side effects. Here, we paired nanotechnology with an established dimeric glycoprotein VI-Fc (GPVI-Fc) and a GPVI-CD39 fusion protein, thereby combining site-specific delivery and new antithrombotic drugs. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles, NP-BSA, NP-GPVI and NP-GPVI-CD39 were characterized through electron microscopy, atomic force measurements and flow cytometry. Light transmission aggregometry enabled analysis of platelet aggregation. Thrombus formation was observed through flow chamber experiments. NP-GPVI and NP-GPVI-CD39 displayed a characteristic surface coating pattern. Fluorescence properties were identical amongst all samples. NP-GPVI and NP-GPVI-CD39 significantly impaired platelet aggregation. Thrombus formation was significantly impaired by NP-GPVI and was particularly impaired by NP-GPVI-CD39. The receptor-coated nanoparticles NP-GPVI and the bifunctional molecule NP-GPVI-CD39 demonstrated significant inhibition of in vitro thrombus formation. Consequently, the nanoparticle-mediated antithrombotic effect of GPVI-Fc, as well as GPVI-CD39, and an additive impact of CD39 was confirmed. In conclusion, NP-GPVI and NP-GPVI-CD39 may serve as a promising foundation for a novel therapeutic approach regarding targeted antithrombotic therapy. 相似文献
78.
Maria Luisa Introvigne Magdalena A. Taracila Prof. Fabio Prati Prof. Emilia Caselli Prof. Robert A. Bonomo 《ChemMedChem》2020,15(14):1283-1288
Boronic acids are known reversible covalent inhibitors of serine β-lactamases. The selectivity and high potency of specific boronates bearing an amide side chain that mimics the β-lactam's amide side chain have been advanced in several studies. Herein, we describe a new class of boronic acids in which the amide group is replaced by a bioisostere triazole. The boronic acids were obtained in a two-step synthesis that relies on the solid and versatile copper-catalyzed azide–alkyne cycloaddition (CuAAC) followed by boronate deprotection. All of the compounds show very good inhibition of the Klebsiella pneumoniae carbapenemase KPC-2, with Ki values ranging from 1 nM to 1 μM, and most of them are able to restore cefepime activity against K. pneumoniae harboring blaKPC-2. In particular, compound 1 e , bearing a sulfonamide substituted by a thiophene ring, proved to be an excellent KPC-2 inhibitor (Ki=30 nM); it restored cefepime susceptibility in KPC-Kpn cells (MIC=0.5 μg/mL) with values similar to that of vaborbactam (Ki=20 nM, MIC in KPC-Kpn 0.5 μg/mL). Our findings suggest that α-triazolylboronates might represent an effective scaffold for the treatment of KPC-mediated infections. 相似文献
79.
Dr. Mariafrancesca Hyeraci Dr. Marialuigia Colalillo Prof. Luca Labella Prof. Fabio Marchetti Prof. Simona Samaritani Dr. Valeria Scalcon Prof. Maria Pia Rigobello Prof. Lisa Dalla Via 《ChemMedChem》2020,15(15):1464-1472
Platinum(II) complexes of the type [Pt(Cl)(PPh3){(κ2-N,O)-(1{C(R)=N(OH)-2(O)C6H4})}] with R=Me, H, ( 1 and 2 ) were synthesized and characterized. Single-crystal X-ray diffraction confirmed the proposed (SP4-3) configuration for 1 . Study of the antiproliferative activity, performed on a panel of human tumor cell lines and on mesothelial cells, highlighted complex 2 as the more effective. In particular, it showed a remarkable cytotoxicity in ovarian carcinoma cells (A2780) and interestingly, a significant antiproliferative effect on cisplatin resistant cells (A2780cis). Investigation into the intracellular mechanism of action demonstrated that 2 had a lower ability to platinate DNA than did cisplatin, which was taken as reference, and a notably higher uptake in resistant cells. A significant accumulation in mitochondria, along with the ability to induce concentration-dependent mitochondrial membrane depolarization and intracellular reactive oxygen species production, allowed us to propose a mitochondrion-mediated pathway as responsible for the interesting cytotoxic profile of complex 2 . 相似文献
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