不完全观测数据下混合效应模型的正交投影估计

基于矩阵的QR分解技术,对一类含有不完全观测数据的线性混合效应模型提出了一种基于正交投影的估计方法。在一些正则条件下,证明了固定效应参数的估计渐近服从标准正态分布,得到了固定效应参数的置信区间。另外,所提出的固定效应参数的估计过程不受随机效应的任何影响,具有较好的有效性和稳健性。最后,通过一些数值模拟和一个实例分析研究了所提出估计方法的有限样本性质。     

Medical image contrast enhancement based on improved sparrow search algorithm

The collection or transmission of medical images is often disturbed by various factors, such as insufficient brightness and noise pollution, which will result in the deterioration of image quality and significantly affect the clinical diagnosis. To improve the quality of medical images, a contrast enhancement method based on improved sparrow search algorithm is proposed in this paper. The method is divided into two steps to enhance the medical images. First, a new transform function is introduced to improve the brightness or contrast of medical images, and two parameters in the transform function are optimized by the improved sparrow search algorithm. Second, adaptive histogram equalization method with contrast limited is used to equalize the result image of the previous step to make the pixel distribution of the image more uniform. Finally, a large number of experiments and qualitative and quantitative analyses were conducted on the common data sets. The analysis results demonstrate that the presented approach outperforms some existing medical image processing approaches.     

DNA-Directed alkylating agents. 7. Synthesis, DNA interaction, and antitumor activity of bis(hydroxymethyl)- and bis(carbamate)-substituted pyrrolizines and imidazoles

A series of bis(hydroxymethyl)-substituted imidazoles, thioimidazoles, and pyrrolizines and related bis(carbamates), linked to either 9-anilinoacridine (intercalating) or 4-(4-quinolinylamino)benzamide (minor groove binding) carriers, were synthesized and evaluated for sequence-specific DNA alkylation and cytotoxicity. The imidazole and thioimidazole analogues were prepared by initial synthesis of [(4-aminophenyl)alkyl]imidazole-, thioimidazole-, or pyrrolizine dicarboxylates, coupling of these with the desired carrier, and reduction to give the required bis(hydroxymethyl) alkylating moiety. The pyrrolizines were the most reactive alkylators, followed by the thioimidazoles, while the imidazoles were unreactive. The pyrrolizines and some of the thioimidazoles cross-linked DNA, as measured by agarose gel electrophoresis. Strand cleavage assays showed that none of the compounds reacted at purine N7 or N3 sites in the gpt region of the plasmid gpt2Eco, but the polymerase stop assay showed patterns of G-alkylation in C-rich regions. The corresponding thioimidazole bis(carbamates) were more selective than the bis(hydroxymethyl) pyrrolizines, with high-intensity bands at 5'-NCCN, 5'-NGCN and 5'-NCGN sequences in the PCR stopping assay ( indicates block sites). The data suggest that these targeted compounds, like the known thioimidazole bis(carbamate) carmethizole, alkylate exclusively at guanine residues via the 2-amino group, with little or no alkylation at N3 and N7 guanine or adenine sites. The cytotoxicities of the compounds correlated broadly with their reactivities, with the bis(hydroxymethyl)imidazoles being the least cytotoxic (IC50s >1 microM; P388 leukemia) and with the intercalator-linked analogues being more cytotoxic than the corresponding minor-groove-targeted ones. This was true also for the more reactive thioimidazole bis(carbamates) (IC50s 0.8 and 11 microM, respectively), but both were more active than the analogous "untargeted" carmethizole (IC50 20 microM). The bis(hydroxymethyl)pyrrolizine analogues were the most cytotoxic, with IC50s as low as 0.03 microM.     

冲击式机组动能参数在线监测

鉴于冲击式水轮机结构上的特殊性,其流量效率等动能参数在线监测目前在国内还是项空白,针对冲击式机组的具体情况,探讨了基于压差理论的监测途径,在此基础上结合一个冲击式电站的实例,设计出了利用单片机来实现的方案．     

图的正交(g,f)-因子分解

设ｇ和ｆ分别是定义在图Ｇ的顶点集合Ｖ（Ｇ）上的整数值函数且对每一个ｘ∈Ｖ（Ｇ）有２≤ｇ（ｘ）≤ｆ（ｘ）．证明了若Ｇ是（ｍｇ＋ｍ－１,ｍｆ－ｍ＋１）—图,则对Ｇ中任意一个给定的有ｍ条边的子图Ｈ,Ｇ有一个（ｇ,ｆ）—因子分解与Ｈ正交．     

“迭代-降维-梯度搜索法”求解Dobbins模型参数研究

文章介绍了用“迭代－降维－梯度搜索法”求解Dobbins模型参数的研究成果。该法能解决目前存在的用梯度法搜索参数时误差较大及用“计算机扫描计算－图解－梯度搜索法”寻求参数时计算量较大的问题。     

建筑施工与管理专业教学计划整体构想

借鉴CBE/DACUM教育模式,提出了我国高等工程专科学校教育目标确定的方法,并就建筑施工与管理专业理论教育内容、职业能力的培养、学校与企业合作培养人才机制进行了研究,确定了专业人才培养目标模式和课程体系。     

正确把握“三个环节” 做好经常性思想工作

“及时发现,确实弄清,正确解决”是做好经常性思想工作的３个基本环 节。“及时发现”是做好经常性思想工作的前提,要做到及时发现,一要把握规律,搞好 预测;二要留心观察,掌握细微;三是个别交谈,讲究艺术;四要摸底测试,搞好普查; 五是会议收集,全面分析。“确实弄清”是做好经常性思想工作的关键,一要搞好调查 研究,弄清思想问题的真正原因;二要进行科学分析,弄清思想问题的本质。“正确解 决”是做好经常性思想工作的目的,一要动之以情;二要晓之以理;三要喻之以义;四 要导之以行。     

板坯连铸辊失效原因及其修复技术

首先介绍连铸辊失效的基本形式,提出了极限寿命的概念及开展修复的意义．然后从不同角度分析了辊子裂纹产生的影响因素,并给出实际断口的典型形貌．最后就目前常用的修复方法进行了比较,提出修复新方法设想．     

两类古典概率的阶乘近似计算

改进了一个阶乘的不等式,并在此基础上,对有关含有阶乘的两类古典概率二项分布和超几何分布的近似计算问题进行了讨论．