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We study the problem of non-preemptively scheduling n independent sequential jobs on a system of m identical parallel machines in the presence of reservations, where m is constant. This setting is practically relevant because for various reasons, some machines may not be available during specified time intervals. The objective is to minimize the makespan C max, which is the maximum completion time. 相似文献
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Saint Martin Marie-Judith Orlhac Fanny Akl Pia Khalid Fahad Nioche Christophe Buvat Irène Malhaire Caroline Frouin Frédérique 《Magma (New York, N.Y.)》2021,34(3):355-366
Magnetic Resonance Materials in Physics, Biology and Medicine - Quantitative analysis in MRI is challenging due to variabilities in intensity distributions across patients, acquisitions and... 相似文献
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Kate Dunning Adeline Martz Francisco Andrs Peralta Federico Cevoli Eric Bou-Grabot Vincent Compan Fanny Gautherat Patrick Wolf Thierry Chataigneau Thomas Grutter 《International journal of molecular sciences》2021,22(12)
P2X7 receptors (P2X7) are cationic channels involved in many diseases. Following their activation by extracellular ATP, distinct signaling pathways are triggered, which lead to various physiological responses such as the secretion of pro-inflammatory cytokines or the modulation of cell death. P2X7 also exhibit unique behaviors, such as “macropore” formation, which corresponds to enhanced large molecule cell membrane permeability and current facilitation, which is caused by prolonged activation. These two phenomena have often been confounded but, thus far, no clear mechanisms have been resolved. Here, by combining different approaches including whole-cell and single-channel recordings, pharmacological and biochemical assays, CRISPR/Cas9 technology and cell imaging, we provide evidence that current facilitation and macropore formation involve functional complexes comprised of P2X7 and TMEM16, a family of Ca2+-activated ion channel/scramblases. We found that current facilitation results in an increase of functional complex-embedded P2X7 open probability, a result that is recapitulated by plasma membrane cholesterol depletion. We further show that macropore formation entails two distinct large molecule permeation components, one of which requires functional complexes featuring TMEM16F subtype, the other likely being direct permeation through the P2X7 pore itself. Such functional complexes can be considered to represent a regulatory hub that may orchestrate distinct P2X7 functionalities. 相似文献
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The clinical validity of the Chinese Personality Assessment Inventory (CPAI; F. M. Cheung, K. Leung, et al., 1996) was examined in 2 studies involving a group of 167 male prisoners in Hong Kong and a group of 339 psychiatric patients in China. Elevated scores on the clinical scales were obtained for the clinical samples. Logistic regression analyses confirmed that the CPAI scales were useful in differentiating between male prisoners and the Hong Kong male normative sample and between psychiatric patients and a random sample of normal adults in China. Multivariate analyses of variance results showed significant differences on the CPAI clinical scales and personality scales among subgroups of psychiatric patients with diagnoses of bipolar, schizophrenic, and neurotic disorders. The usefulness of an indigenous personality inventory is discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Different ways for grafting ester derivatives of poly(ethylene glycol) onto chitosan: related characteristics and potential properties 总被引:1,自引:0,他引:1
The grafting of poly(ethylene glycol) functionalized by ester groups (MeO-PEG-ester) onto chitosan was studied and optimized using different reaction conditions. In a first procedure, the grafting was made from 6-O-triphenylmethyl-chitosan after protection of primary hydroxyl groups and in a second one, it was made directly onto chitosan. NMR spectroscopy was an important tool to study these reactions and the grafting is unequivocally showed up. Moreover, for each procedure, the solubility and surface properties of the obtained copolymers were evaluated and compared. 相似文献
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The Chinese Minnesota Multiphasic Personality Inventory—Adolescents (MMPI—A) was applied in Hong Kong to a normative sample of 565 male and 664 female students ages 14–18. The Chinese adolescents' MMPI–A T scores based on the U.S. adolescent norms were elevated more than 1 SD on Scale 2. Similar elevations were found on Scale L (Lie) for the female students and on Scale A-lse (Adolescent Low Self-Esteem) for the male students. Moderate elevations were also shown on several scales, although none of the clinical scales exceeded a T score of 65, the clinical cutoff point based on U.S. norms. Whether these elevations were due to cultural differences in item interpretation or higher levels of psychopathology among the Hong Kong students cannot be concluded from the present data. However, previous findings on the Chinese MMPI favors the former explanation. These cultural differences should be taken into consideration in clinical interpretations of elevated scores on the Chinese MMPI—A. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献