A framework for fusion methods and rendering techniques of multimodal volume data

Many different direct volume rendering methods have been developed to visualize 3D scalar fields on uniform rectilinear grids. However, little work has been done on rendering simultaneously various properties of the same 3D region measured with different registration devices or at different instants of time. The demand for this type of visualization is rapidly increasing in scientific applications such as medicine in which the visual integration of multiple modalities allows a better comprehension of the anatomy and a perception of its relationships with activity. This paper presents different strategies of direct multimodal volume rendering (DMVR). It is restricted to voxel models with a known 3D rigid alignment transformation. The paper evaluates at which steps of the rendering pipeline the data fusion must be realized in order to accomplish the desired visual integration and to provide fast re‐renders when some fusion parameters are modified. In addition, it analyses how existing monomodal visualization algorithms can be extended to multiple datasets and it compares their efficiency and their computational cost. Copyright © 2004 John Wiley & Sons, Ltd.     

Phylogeny and rapid northern and southern hemisphere speciation of goldfinches during the Miocene and Pliocene epochs

Mitochondrial cytochrome b (cyt b) from 25 out of 31 extant goldfinches, siskins, greenfinches and redpolls (genus Carduelis) has been sequenced from living samples taken around the world, specimens have also been photographed. Phylogenetic analysis consistently gave the same groups of birds, and this grouping was generally related to geographical proximity. It has been supposed that Pleistocene glaciations played a crucial role in the origin of extant diversity and distribution of Northern Hemisphere vertebrates. Molecular comparison of most extant songbird species belonging to the genus Carduelis does not support this assertion. The fossil record of chicken and pheasant divergence time has been used to calibrate the molecular clock; cyt b DNA dendrograms suggest that speciation in Carduelinae birds occurred during the Miocene and Pliocene Epochs (9-2 million years ago) in both the Northern and Southern Hemispheres. Only about 4% average amount of nucleotide substitution per lineage is found between the most distant Carduelis species; this suggests a remarkably rapid radiation when compared with the radiation of other passerine songbird genera. In addition, a continuum of small songbird speciation may be found during the Miocene Epoch in parallel with speciation of other orders (i.e. Galliformes, chicken/pheasant). Pleistocene glaciations may have been important in subspeciation (i.e. Eastern European grey-headed goldfinches/Western European black-headed goldfinches) and also in ice-induced vicariance (isolation) (i.e. siskin in Western Europe vs. siskin in Far East Asia) around the world. European isolated Serinus citrinella (citril finch) is not a canary, but a true goldfinch. South American siskins have quickly radiated in the last 4 million years coinciding with the emergence of the Isthmus of Panama; probably, a North American siskin related to C. notata invaded a suitable and varied biotope (the South American island) for Carduelis birds. North American goldfinches may be renamed as siskins, because they have a distant genetic relationship with European goldfinches. Genus Acanthis could be dropped, and thus redpolls should be separated from twite and linnet, the latter (Europeans) probably being related to American goldfinches. Also, reproductive barriers are observed between closely related species and not between other more distant ones. Finally, a tentative classification for genus Carduelis species is suggested.     

Rilmenidine normalizes fructose-induced insulin resistance and hypertension in rats

OBJECTIVE: The aim of this study was to determine the effects of rilmenidine (an antihypertensive drug that lowers blood pressure by decreasing sympathetic outflow) in an animal model of hypertension associated with insulin resistance, i.e. rats fed on a high-fructose diet. DESIGN: Wistar rats were fed for 4 weeks either on a standard diet (S group) or on a high-fructose diet (F group; 34.5% fructose). In half of the rats in the F group, rilmenidine (1 mg/kg per day) was added to the drinking water for the last 2 weeks of the diet (FR group). RESULTS: Body weight gain was higher in the F than in the S rats (66+/-8g versus 45+/-8g, P< 0.05), but was prevented by rilmenidine treatment (32+/-2g). Arterial systolic blood pressure was increased in F rats (162+/-2 versus 155+/-2 mmHg, P< 0.05), rilmenidine reduced this value to normal (149+/-3 mmHg). Glucose tolerance, glucose turnover rate, and insulin secretion were not modified by the diet or by the drug. However, during a euglycemic hyperinsulinemic clamp, glucose utilization was lower (10+/-1 versus 14+/-1.5 mg/min per kg; P< 0.05) and hepatic glucose production higher (1+/-0.01 versus 0 mg/min per kg, P< 0.01) in F than in S rats. These changes in insulin action were totally abolished by rilmenidine. CONCLUSIONS: These data demonstrate that rilmenidine can ameliorate the deleterious effects of a high-fructose diet, i.e. weight gain, hypertension, and resistance to the effects of insulin.     

Analysis of dynamic conditions during thermal transient events for the structural assessment of a nuclear vessel

The possibility of dynamic loading conditions in a reactor pressure vessel (RPV) has been investigated in this paper. For this purpose, finite element (FE) numerical simulations of several thermal transients were performed including a normal shut down and two accidental thermal shocks, namely a loss of coolant accident (LOCA) and an extreme postulated pressurised thermal shock (PTS). The aim of the present contribution is to evaluate the influence of the loading rate on the fracture properties of the vessel steel of the Santa María de Garoña Spanish nuclear power plant (NPP) in the ductile to brittle transition (DBT) region. To describe the fracture behaviour of the steel in the DBT region, the master curve (MC) reference temperature, T₀, was used. This temperature is normally used for quasi-static conditions; however, it has been recently extended to the determination of dynamic fracture toughness by means of a phenomenological model proposed by Wallin. The dynamic reference temperature, T_0,dyn, was obtained for the loading rates corresponding to the three studied situations numerically simulated and compared with the quasi-static reference temperature, T_0,sta. From these results, conclusions about the importance of loading rates in nuclear vessels were established.     

Effects of mismatch strain and alloy composition on the formation of InAs islands on InAlAs templates

InAs islands self-assembled on InAlAs layers lattice mismatched on GaAs substrates have been grown by molecular beam epitaxy. Both pseudomorphic and metamorphic InAlAs buffer layers were used as a template to investigate the effects of strain relaxation on the formation of the islands. The effect of alloy composition in the metamorphic templates is shown on the density and the shape of the islands. The present observations confirms the reduction of surface mass transport due to aluminum in the buffer layers.     

Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements

The investigation of tripeptide aldehydes as reversible covalent inhibitors of human rhinovirus (HRV) 3C protease (3CP) is reported. Molecular models based on the apo crystal structure of HRV-14 3CP and other trypsin-like serine proteases were constructed to approximate the binding of peptide substrates, generate transition state models of P1-P1' amide cleavage, and propose novel tripeptide aldehydes. Glutaminal derivatives have limitations since they exist predominantly in the cyclic hemiaminal form. Therefore, several isosteric replacements for the P1 carboxamide side chain were designed and incorporated into the tripeptide aldehydes. These compounds were found to be potent inhibitors of purified HRV-14 3CP with Kis ranging from 0.005 to 0.64 microM. Several have low micromolar antiviral activity when tested against HRV-14-infected H1-HeLa cells. The N-acetyl derivative 3 was also shown to be active against HRV serotypes 2, 16, and 89. High-resolution cocrystal structures of HRV-2 3CP, covalently bound to compounds 3, 15, and 16, were solved. These cocrystal structures were analyzed and compared with our original HRV-14 3CP-substrate and inhibitor models.     

Stereoscopic human interfaces

This article focuses on the use of stereoscopic video interfaces for telerobotics. Topics concerning human visual perception, binocular image capturing, and stereoscopic devices are described. There is a wide variety of video interfaces for telerobotic systems [1]. Choosing the best video interface depends on the telerobotic application requirements. Simple monoscopic cameras are good enough for watching remote robot movements or for teleprogramming a sequence of commands. However, when operators seek precise robot guidance or wish to manipulate objects, a better perception of the remote environment must be achieved, for which more advanced visual interfaces are required. This implies a higher degree of telepresence, and, therefore, the most suitable visual interface has to be chosen. The aim of this article is to describe the two main aspects using stereoscopic interfaces: · the capture of binocular video images, according to the disparity limits in human perception · the proper selection of the visualization interface for stereoscopic images.     

Comprehensive modeling of the temperature-related laser performances of the amplifiers of the LUCIA laser

We present numerical simulations of the temperature-related laser performance of the amplifiers for the Lasers Ultra-Courts et Intenses et Applications (LUCIA) laser, a 100 J, 10 Hz, 10 ns diode-pumping solid-state-laser facility, which uses Yb3+:YAG as the gain medium. The simulations include energy storage and extraction efficiency, cooling of the gain medium, and wavefront distortion. The results show that, with a pumping intensity of 20 kW/cm2 at 10 Hz and a doping concentration of 10 at. % at a thickness of Yb3+:YAG of 1.6 mm, the output laser fluence and optical-to-optical efficiency are expected to be 10 J/cm2 and 25.8%, respectively, at a heat exchange coefficient of 3000 W/m2/K of water. Also, the matching thickness of undoped YAG is optimized to prevent bending deformation of the gain medium, which could be approximately 5 mm.     

Bilateral control by state convergence based on transparency for systems with time delay

This paper proposes a new methodology for designing master and slave controllers based on state convergence that aims to reach the most transparency considering communication time delay. This method shows a modified scheme of the state convergence algorithm that feeds back the state of the slave to the master controller. All this information (position, velocity and torque) is processed in order to implement the desired master behavior that has to guarantee the stability of the system and the best remote impedance reflection as possible. This paper shows some experiments that prove the performance of this methodology for a second order-modeled system with 3 degrees of freedom. Moreover, this methodology can also be applied in higher order systems of teleoperation models.