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991.
Bermúdez Aurelio Montero Francisco López María T. Fernández-Caballero Antonio Sánchez José L. 《The Journal of supercomputing》2019,75(3):1670-1685
The Journal of Supercomputing - The lateral interaction in accumulative computation (LIAC) algorithm is a biologically inspired method that allows us to detect moving objects from image sequences... 相似文献
992.
993.
Bernardino Clavo Gregorio Martínez-Snchez Francisco Rodríguez-Esparragn Delvys Rodríguez-Abreu Saray Galvn David Aguiar-Bujanda Juan A. Díaz-Garrido Silvia Caas Laura B. Torres-Mata Himar Fabelo Teresa Tllez Norberto Santana-Rodríguez Leandro Fernndez-Prez Gustavo Marrero-Callico 《International journal of molecular sciences》2021,22(6)
(1) Background: Chemotherapy-induced peripheral neuropathy (CIPN) decreases the quality of life of patients and can lead to a dose reduction and/or the interruption of chemotherapy treatment, limiting its effectiveness. Potential pathophysiological mechanisms involved in the pathogenesis of CIPN include chronic oxidative stress and subsequent increase in free radicals and proinflammatory cytokines. Approaches for the treatment of CIPN are highly limited in their number and efficacy, although several antioxidant-based therapies have been tried. On the other hand, ozone therapy can induce an adaptive antioxidant and anti-inflammatory response, which could be potentially useful in the management of CIPN. (2) Methods: The aims of this works are: (a) to summarize the potential mechanisms that could induce CIPN by the most relevant drugs (platinum, taxanes, vinca alkaloids, and bortezomib), with particular focus on the role of oxidative stress; (b) to summarize the current situation of prophylactic and treatment approaches; (c) to describe the action mechanisms of ozone therapy to modify oxidative stress and inflammation with its potential repercussions for CIPN; (d) to describe related experimental and clinical reports with ozone therapy in chemo-induced neurologic symptoms and CIPN; and (e) to show the main details about an ongoing focused clinical trial. (3) Results: A wide background relating to the mechanisms of action and a small number of experimental and clinical reports suggest that ozone therapy could be useful to prevent or improve CIPN. (4) Conclusions: Currently, there are no clinically relevant approaches for the prevention and treatment of stablished CIPN. The potential role of ozone therapy in this syndrome merits further research. Randomized controlled trials are ongoing. 相似文献
994.
Laura Martínez-Valenzuela Juliana Draibe Xavier Fulladosa Montserrat Gom Francisco Gmez Paula Antn Josep María Cruzado Joan Torras 《International journal of molecular sciences》2021,22(5)
Acute kidney injury in patients who suffer a malignancy is a common complication. Due to its high prevalence and effective treatment, one of the most frequent causes that both oncologists and nephrologists must be aware of is acute tubulointerstitial nephritis (ATIN). ATIN is an immunomediated condition and the hallmark of the disease, with the presence of a tubulointerstitial inflammatory infiltrate in the renal parenchyma. This infiltrate is composed mainly of T lymphocytes that can be accompanied by macrophages, neutrophils, or eosinophils among other cells. One of the major causes is drug-related ATIN, and some antineoplastic treatments have been related to this condition. Worthy of note are the novel immunotherapy treatments aimed at enhancing natural immunity in order to defeat cancer cells. In the context of the immunosuppression status affecting ATIN patients, some pathogen antigens can trigger the development of the disease. Finally, hematological malignancies can also manifest in the kidney leading to ATIN, even at the debut of the disease. In this review, we aim to comprehensively examine differential diagnosis of ATIN in the setting of a neoplastic patient. 相似文献
995.
Karen C. A. Francisco Pedro F. Brandão Rui Miguel Ramos Luís Moreira Gonçalves Arnaldo A. Cardoso José António Rodrigues 《International Journal of Food Science & Technology》2020,55(1):248-258
Biogenic amines (BAs) are compounds present in foodstuff of animal origin that not only can be harmful to the consumer but can also serve as indicators of the product's edibility status. However, BAs’ analysis is rather complicated. Derivatisation methods have been employed to make their analysis less challenging. Salting-out assisted liquid–liquid extraction (SALLE) was herein applied to decrease time that the derivatising agent dansyl chloride (DNS-Cl) requires to be effective. DNS-Cl derivates were separated and analysed by high-performance liquid chromatography with UV and fluorescence detection (HPLC-UV/FD). It was by this way possible to analyse methylamine, dimethylamine, ethylamine, β-phenylethylamine, isopentylamine, putrescine, cadaverine, histamine, tyramine, spermidine and spermine in a straightforward manner in several fish-based and meat-based samples, obtaining results in the order of magnitude of about a few mg per kg. All calibrations curves had r2 higher than 0.99, and limits of detection ranged from 0.0075 to 1.6 mg L−1. 相似文献
996.
Neves Roberta Motta Lopes Kirk Silveira Lazzari Lídia Kunz Monticeli Francisco Maciel Zattera Ademir José 《Journal of Porous Materials》2021,28(4):1081-1095
Journal of Porous Materials - Supercritical carbon dioxide (scCO2) has been used as a physical blowing agent to produce polymer expanded materials. Firstly, a statistic study was performed to... 相似文献
997.
Fortes Juan Carlos Dávila José Miguel Sarmiento Aguasanta Miguel Luís Ana Teresa Santisteban María Díaz-Curiel Jesús Córdoba Francisco Grande José Antonio 《Mine Water and the Environment》2022,41(3):848-848
Mine Water and the Environment - 相似文献
998.
Mohamed Bayati Danh C. Vu Phuc H. Vo Elizabeth Rogers Jihyun Park Thi L. Ho Alexandra N. Davis Zehra Gulseven Gustavo Carlo Francisco Palermo Jane A. McElroy Susan C. Nagel Chung-Ho Lin 《Indoor air》2021,31(4):977-988
Children are particularly vulnerable to many classes of the volatile organic compounds (VOCs) detected in indoor environments. The negative health impacts associated with chronic and acute exposures of the VOCs might lead to health issues such as genetic damage, cancer, and disorder of nervous systems. In this study, 40 VOCs including aldehydes and ketones, aliphatic hydrocarbons, esters, aromatic hydrocarbons, cyclic terpenes, alcohols, and glycol ethers were identified and qualified in different locations at the University of Missouri (MU) Child Development Laboratory (CDL) in Columbia, Missouri. Our results suggested that the concentrations of the VOCs varied significantly among classrooms, hallways, and playground. The VOCs emitted from personal care and cleaning products had the highest indoor levels (2-ethylhexanol-1, 3-carene, homomenthyl salicylate with mean concentration of 5.15 µg/m3, 1.57 µg/m3, and 1.47 µg/m3, respectively). A cancer risk assessment was conducted, and none of the 95th percentile dose estimates exceeded the age-specific no significant risk levels (NSRL) in all classrooms. Dimensionless toxicity index scores were calculated for all VOCs using a novel web-based framework called Toxicological Prioritization Index (ToxPi), which integrates multiple sources of toxicity data. According to the method, homomenthyl salicylate, benzothiazole, 2-ethylhexyl salicylate, hexadecane, and tridecane exhibited diverse toxicity profiles and ranked as the five most toxic indoor VOCs. The findings of this study provide critical information for policy makers and early education professionals to mitigate the potentially negative health impacts of indoor VOCs in the childcare facilities. 相似文献
999.
1000.
Bruna Tereza Thomazini Zanella Isabele Cristina Magiore Bruno Oliveira Silva Duran Guilherme Gutierrez Pereira Igor Simes Tiagua Vicente Pedro Luiz Pucci Figueiredo Carvalho Rondinelle Artur Simes Salomo Edson Assuno Mareco Robson Francisco Carvalho Tassiana Gutierrez de Paula Margarida Maria Barros Maeli Dal-Pai-Silva 《International journal of molecular sciences》2021,22(6)
In fish, fasting leads to loss of muscle mass. This condition triggers oxidative stress, and therefore, antioxidants can be an alternative to muscle recovery. We investigated the effects of antioxidant ascorbic acid (AA) on the morphology, antioxidant enzyme activity, and gene expression in the skeletal muscle of pacu (Piaractus mesopotamicus) following fasting, using in vitro and in vivo strategies. Isolated muscle cells of the pacu were subjected to 72 h of nutrient restriction, followed by 24 h of incubation with nutrients or nutrients and AA (200 µM). Fish were fasted for 15 days, followed by 6 h and 15 and 30 days of refeeding with 100, 200, and 400 mg/kg of AA supplementation. AA addition increased cell diameter and the expression of anabolic and cell proliferation genes in vitro. In vivo, 400 mg/kg of AA increased anabolic and proliferative genes expression at 6 h of refeeding, the fiber diameter and the expression of genes related to cell proliferation at 15 days, and the expression of catabolic and oxidative metabolism genes at 30 days. Catalase activity remained low in the higher supplementation group. In conclusion, AA directly affected the isolated muscle cells, and the higher AA supplementation positively influenced muscle growth after fasting. 相似文献