National geodatabase of tidal stream power resource in USA

A geodatabase of tidal constituents is developed to present the regional assessment of tidal stream power resource in the USA. Tidal currents are numerically modeled with the Regional Ocean Modeling System (ROMS) and calibrated with the available measurements of tidal current speeds and water level surfaces. The performance of the numerical model in predicting the tidal currents and water levels is assessed by an independent validation. The geodatabase is published on a public domain via a spatial database engine with interactive tools to select, query and download the data. Regions with the maximum average kinetic power density exceeding 500 W/m² (corresponding to a current speed of ～1 m/s), total surface area larger than 0.5 km² and depth greater than 5 m are defined as hotspots and documented. The regional assessment indicates that the state of Alaska (AK) has the largest number of locations with considerably high kinetic power density, followed by, Maine (ME), Washington (WA), Oregon (OR), California (CA), New Hampshire (NH), Massachusetts (MA), New York (NY), New Jersey (NJ), North and South Carolina (NC, SC), Georgia (GA), and Florida (FL).     

Differential Signaling by Protease-Activated Receptors: Implications for Therapeutic Targeting

Protease-activated receptors (PARs) are a family of four G protein-coupled receptors that exhibit increasingly appreciated differences in signaling and regulation both within and between the receptor class. By nature of their proteolytic self-activation mechanism, PARs have unique processes of receptor activation, “ligand” binding, and desensitization/resensitization. These distinctive aspects have presented both challenges and opportunities in the targeting of PARs for therapeutic benefit—the most notable example of which is inhibition of PAR1 on platelets for the prevention of arterial thrombosis. However, more recent studies have uncovered further distinguishing features of PAR-mediated signaling, revealing mechanisms by which identical proteases elicit distinct effects in the same cell, as well as how distinct proteases produce different cellular consequences via the same receptor. Here we review this differential signaling by PARs, highlight how important distinctions between PAR1 and PAR4 are impacting on the progress of a new class of anti-thrombotic drugs, and discuss how these more recent insights into PAR signaling may present further opportunities for manipulating PAR activation and signaling in the development of novel therapies.     

Applying Earthquake Risk Analysis Techniques to Land Use Planning

Recently developed methods of risk analysis are capable of modeling variations in earthquake hazard and its resultant damage to urban development. This type of risk analysis can provide useful information for land use decisions. Our article describes a probabilistic approach to earthquake risk analysis, which begins by estimating and mapping the expected level of ground motion over a study area. Areas subject to the earthquake-induced secondary hazards of landsliding and liquefaction are identified and combined with ground motion to describe the overall hazard. Damage estimates (by type of structure) can be produced for either the existing land use pattern or alternative future scenarios; that information can be used to evaluate alternative land use patterns in terms of their potential for earthquake damage. To illustrate the approach we use a case study application of earthquake risk analysis techniques to an area in San Luis Obispo County, California. We summarize the reactions of several practicing planners to this method of earthquake risk assessment, and we discuss the implications of improved risk analysis techniques for land use planning.     

From outpost to outback: project career paths in Australia

With the growth in project management as a form of work organisation in many sectors of the economy has come the significant rise in the number of project managers and project team members. This change in work organisation brings issues in forging career paths and determining career support in work situations that are often dynamic, short lived and intense. In the relatively small but substantially robust Australian economy, a unique labour market and the tyranny of distance bring their own difficulties. Innovative and collaborative project structures and increasing prevalence of contract work provide both challenges and opportunities for new career pathways in many industries. A growing percentage of Australia's workforce is employed in project-based or project-oriented organisations, leading to the claim that Australia is a project-based economy. This provided a context for our research into the career paths and the issues of career management for project managers working in a project based economy. Using in-depth interviews with project managers from three industry areas we found generational and gender differences in experiences of work, workplace support and mentoring for career development. For a continued strong performance in this economy, organisations that employ project personnel will need to consider how they will ensure the supply of high quality project professionals into the future.     

影像导引肝脏恶性肿瘤多模态消融治疗技术专家共识

影像导引肝脏恶性肿瘤多模态消融治疗是以医学影像技术为导引,在冷冻消融与热消融交替转换过程中,通过对病灶区温度精准控制和消融过程定量规划,彻底破坏原位肿瘤细胞及其循环系统,同时最大程度释放活性肿瘤抗原,从而达到控制肝脏恶性肿瘤复发转移的目的。为规范肝脏恶性肿瘤多模态消融治疗技术操作,便于不同层级医院开展实施,确保医疗安全和临床疗效,中国抗癌协会肿瘤介入学专业委员会和上海市抗癌协会实体肿瘤聚焦诊疗专业委员会组织国内肿瘤治疗领域的多学科专家共同参与,认真讨论,最终达成本共识。     

下肢深静脉血栓形成介入治疗规范的专家共识（第2版）

【摘要】 基于第1版专家共识,对介入治疗下肢深静脉血栓形成（DVT）所涉及的抗凝、经导管接触性溶栓治疗（CDT）、经皮机械性血栓清除术（PMT）、经皮腔内血管成形术（PTA）及支架植入术的适应证和禁忌证,以及各种介入技术的操作步骤、注意事项、围手术期处理和并发症防治等,进行更新、补充、修订。再次强调重视急性期和亚急性期DVT介入治疗,以降低血栓后综合征（PTS）发生率。
     

2019 Annual Report of China's Paper Industry

According to the 2019 annual report of China’s Paper Industry by China Paper Association (CPA), in 2019, there were about 2700 paper & board manufacturers in mainland China. The total production of paper & board was 107.65 million tons, increased by 3.16% and the total consumption was 107.04 million tons, increased by 2.54% compared with 2018, respectively, paper & board per capita consumption was 75 kg (counted in 1.4 billion people). This report includes a rather elaborate analysis of the China’s paper industry and is provided for the readers’ reference.     

我国太阳热水器产业发展现状与对策

经过近２０年的研究和科技成果转化,太阳热水器技术已趋成熟。随着改革开放,人民生活质量不断提高,生活热水正在成为现代文明生活中不可缺少的需求。太阳热水器市场不断扩大,太阳热水器产业迅速发展。据不完统计,全国已有 １０００多家企业,从事研制、生产、销售和安装服务业务。太阳热水器已成为太阳能热利用产业的主流。１太阳热水器产业发展现状 我国市场上销售的太阳热水器基本上可分为三大类型产品,即闷晒热水器、平板热水器和真空管（包括热管）热水器。其中间晒热水器的生产主要以中小型企业为主。 平板热水器的核心部分是平…     

Enhanced microbial oil production by activated sludge microorganisms via co‐fermentation of glucose and xylose

The co‐fermentation of glucose and xylose by activated sludge microorganisms for the production of microbial oils for use as biodiesel feedstock was investigated. Various carbon sources at initial concentration of 60 g/L and C:N ratio 70:1 were investigated: xylose, glucose, and 2:1 and 1:2 (by mass) glucose/xylose mixtures. Oil accumulation ranged between 12 to 22% CDW, the highest of which was obtained when xylose was the sole substrate used. Kinetic modeling of the fermentation data showed that specific growth and oil accumulation rates were similar in all substrate types and the lipid coefficient ranged from 0.02 to 0.06 g/g of sugar consumed. The fatty acid methyl ester yield and composition of the lipids showed their suitability for conversion to biodiesel. Based on the results, lignocellulose sugars could be used as fermentation substrates by activated sludge microorganisms for enhancing the oil content of sewage sludge for its use as a sustainable biofuel feedstock source. © 2013 American Institute of Chemical Engineers AIChE J, 59: 4036–4044, 2013     

1～8月混凝土与水泥制品行业经济运行情况

宏观经济观察:投资保持平稳增长经济增长持续放缓据国家宏观经济数据显示,今年1～8月,全社会固定资产投资(不含农)180608亿元,同比增长25%,比1～7月回落0.4个百分点。1～8月,全国房地产开发投资37781亿元,同比增长33.2%。8月份,规模以上工业增加值同比增长13.5%,比7月份回落0.5个百分点。1～8