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61.
Chin‐Yang Lee Chi‐Hung Liu Chih‐Wei Chen Saodo Miki Huang‐Ming Philip Chen Shermann Lin Po‐Hua Su Chein‐Dhau Lee 《Journal of the Society for Information Display》2008,16(1):71-75
Abstract— Novel anode layer plasma within minimum chamber space was developed for non‐contact alignment process. The plasma‐treated polyimide (PI) surface showed no particle contamination and no micro‐scratches. Surface morphology was investigated by using scanning electron microscope (SEM), an atomic force microscope (AFM), and X‐ray photoemission spectroscopy. The different oxygen‐to‐carbon ratio ([O]/[C] ratio) for XPS spectra indicated a composition change after plasma treatment. Surface pretilt angles were varied from 0 to 2.1° under different plasma exposure times. Finally, a prototype 20.8‐in. QXGA IPS‐mode gray‐scale medical liquid‐crystal display was successfully demonstrated with high contrast ratio, excellent uniformity, and wide viewing angle using this new plasma‐beam‐alignment technique. 相似文献
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S Murata A Kobayashi T Takeuchi H Nakajima A Yoshida Y Kurosawa S Miki T Mizoguchi T Sakurai A Kawatani 《Canadian Metallurgical Quarterly》1996,65(3):109-119
Argatroban has selective antithrombin activity and widely used for treatment of ASO. In this study we investigated vasodilating activity of Argatroban besides antithrombin activity in ASO patients. Three patients who have undergone F-P bypasses previously which were all occluded received 10 mg or 20 mg of Argatroban per day intravenously for 4 weeks. Skin temperature were measured before and after administration of Argatroban at the point of 1, 2, 4 weeks which increased 2.3-6.0 degrees C after administration of Argatroban. Subjective symptoms were also improved and these patients became to be able to walk 1.5-3.3 km. These patients were also given PGE, intravenously, however, temperature increase was less than 1.1 degrees C. These results showed that Argatroban has not only antithrombin activity but also significant vasodilating activity resulting in increase of skeletal muscle blood flow. 相似文献
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P Esteve N Embade R Perona B Jiménez L del Peso J León M Arends T Miki JC Lacal 《Canadian Metallurgical Quarterly》1998,17(14):1855-1869
Rho proteins are a branch of GTPases that belongs to the Ras superfamily which are critical elements of signal transduction pathways leading to a variety of cellular responses. This family of small GTPases has been involved in diverse biological functions such as cytoskeleton organization, cell growth and transformation, cell motility, migration, metastasis, and responses to stress. We report that several human Rho proteins including Rho A, Rho C and Rac 1, are capable of inducing apoptosis in different cell systems like murine NIH3T3 fibroblasts and the human erythroleukemia K562 cell line. Since K562 cells are devoid of p53, apoptosis induced by Rho in this system is independent of p53. Rho-dependent apoptosis is mediated by the generation of ceramides, and it is drastically inhibited by ectopic expression of Bcl2, both under in vitro and in vivo conditions. Furthermore, the human oncogenes vav and ost that have been shown to function as guanine exchange factors for Rho proteins, were also able to induce apoptosis under similar conditions. Finally, we also report that the levels of endogenous Rho proteins are increased when U937 myeloid leukemia cells are exposed to apoptosis-inducing conditions such as TNF alpha treatment. Furthermore, TNF alpha-induced apoptosis in these cells is inhibited by expression of a dominant negative mutant of Rac 1 but it is not affected by a similar mutant of Rho A. These results suggest that Rho proteins play an important role in the physiological regulation of the apoptotic response to stress-inducing agents. 相似文献
66.
K Miki K Iwata Y Tsuboi R Sumino T Fukuoka T Tachibana A Tokunaga K Noguchi 《Canadian Metallurgical Quarterly》1998,76(3):407-415
During nerve cell degeneration, cholesterol released from the degrading cells is conserved through the formation of a cholesterol-apolipoprotein (apo) E complex which is subsequently taken up by regenerating nerve cells. The aim of the present project was to identify the physiologically relevant lipoprotein receptor for this lipoprotein complex which has remained elusive. HDL was separated into apo E-rich and apo E-poor subfractions and labelled with [14C]-sucrose. Labelled apo E-rich HDL bound to rat brain membranes in a time- and ligand concentration-dependent manner and was a saturable process. Essentially no binding occurred with [14C]-apo E-poor HDL or with free apo E. Binding was partially inhibited by low density lipoprotein (LDL) and by alpha 2-macroglobulin. These results provide new evidence that native apoE-rich HDL particles resembling those present in the brain bind to rat brain membranes and that the binding may be due, at least in part, to the LDL receptor and to the LDL-receptor related protein. Evidence was also provided for the presence of a receptor which binds [14C]-sucrose human apoE-rich HDL in human brain. Characterisation of the receptor which mediates the uptake of cholesterol from HDL-like complexes by brain cells is important in understanding the role of apoE in the central nervous system and of the alterations which occur in disorders such as Alzheimer's disease. 相似文献
67.
MD Phillips RI Grossman Y Miki L Wei DL Kolson MA van Buchem M Polansky JC McGowan JK Udupa 《Canadian Metallurgical Quarterly》1998,19(6):1055-1060
A kinetic analysis of degradation of saturated oligoguluronates by poly(alpha-L-guluronate)lyase from Corynebacterium sp. ALY-1 strain was done. The saturated oligoguluronates were prepared by hydrolyzing poly alpha-1,4-L-guluronate from alginate with HCl, and then by gel filtration on a Bio-Gel P-6 column. The saturated pentaguluronate or above were rapidly degraded by the enzyme, while tetraguluronate was slowly degraded. From the dependency of the catalytic rate constant (kcat) on the degree of polymerization of substrates, the enzyme was found to have a subsite size corresponding to hexaguluronate units. The action pattern of the enzyme on hexaguluronate suggested that the catalytic site of the enzyme was matched to the linkage between the second and third uronic residue from the non-reducing end, since the substrate was mainly split into a unsaturated tetramer and a saturated dimer from a HPLC analysis. 相似文献
68.
69.
K Miki K Kubota N Kokudo Y Inoue Y Bandai M Makuuchi 《Canadian Metallurgical Quarterly》1997,38(11):1798-1807
The decades just before and after the founding of the American Public Health Association in 1872 saw an efflorescence of political cartooning and caricature in national-circulation weeklies. Part of the political and social critique that cartoonists and their editors provided the public focused on needs or opportunities for preventing illness and accidents. This paper presents a small selection of editorial cartoons that agitated in support of public health activities over 4 decades. The goals are to illustrate several concerns that rose to national prominence in that era, to examine the kinds of imagery that newspapers and magazine editors offered their readers, and to observe how frequently the public was encouraged to see politicians and commercial interests as responsible for preventable health problems. This discussion focuses exclusively on propagandistic images, leaving aside the reportorial depictions of events in the news and the neutral illustrations of methods and machines in scientific and technical publications. 相似文献
70.
Yoshihiro A. Kajiwara K. Mori K. Sonoda T. Ueda R. Miki Y. 《IEEE transactions on magnetics》1995,31(4):2389-2407
The problem of magnetic core noise is considered in terms of non-repeatability of the hysteresis loop trace for any repetition of the magnetization process. The examination condition is that the effect of eddy currents is reduced to as low a level as possible. Based on such premises, this paper presents a system which periodically extracts the fluctuation voltage, induced at an arbitrary but specified point of the impressed magnetic field, as an instantaneous value. The minimum extraction interval is mainly determined by the integration time of the digital voltmeter used to measure the voltage and by the time required for transferring the extracted data to a personal computer. Therefore, the upper limit of the repetition frequency for the magnetization is restricted to less than 1 Hz. The serially extracted time data is dealt with in a statistical manner and is arranged in order as a magnitude distribution. Two kinds of cores are tested, one is a Fe-Ni-based amorphous core and the other a supermalloy. The results reveal that each core has distinctive noise features 相似文献