Small Molecule Compounds of Natural Origin Target Cellular Receptors to Inhibit Cancer Development and Progression

Receptors are macromolecules that transmit information regulating cell proliferation, differentiation, migration and apoptosis, play key roles in oncogenic processes and correlate with the prognoses of cancer patients. Thus, targeting receptors to constrain cancer development and progression has gained widespread interest. Small molecule compounds of natural origin have been widely used as drugs or adjuvant chemotherapeutic agents in cancer therapies due to their activities of selectively killing cancer cells, alleviating drug resistance and mitigating side effects. Meanwhile, many natural compounds, including those targeting receptors, are still under laboratory investigation for their anti-cancer activities and mechanisms. In this review, we classify the receptors by their structures and functions, illustrate the natural compounds targeting these receptors and discuss the mechanisms of their anti-cancer activities. We aim to provide primary knowledge of mechanistic regulation and clinical applications of cancer therapies through targeting deregulated receptors.     

屏式过热器同屏各管流量偏差的研究

在电站的各种事故中，锅炉事故所占比例最高，而锅炉的各种事故又以过热器和再热器超湿爆管事故率最高。     

反拱水垫塘底板块轴力在上举力作用下的变化规律探讨

为研究反拱水垫塘底板块轴力特征,以溪洛渡高拱坝和反拱水垫塘为参照,在高水头、大流量作用下,以反拱水垫塘在止水破坏、拱圈单底板块、五底板块和九底板块锚固分别失效为代表工况,对拱圈底板块的轴力在上举力作用下的变化规律进行了试验研究。研究表明,拱圈底板块轴力产生和传递的机理是,底板块上举力诱导了底板块位移和锁定,锁定后相邻底板块产生了约束轴力,同时轴力又反过来向相邻底板块传递直至拱端。轴力沿程可分为冲击强振区和上下游强振区。在冲击强振区,底板块瞬时值较大,时均值小,脉动强度最大,拱圈底板能瞬时锁定形成瞬时拱;在上下游强振区,底板块瞬时值和时均值大,而脉动强度较小,拱圈底板块能长时间锁定形成局部拱。在3个强振区,底板块轴力的优势频率在小于0.2 Hz的低频窄带。试验条件下拱圈底板块不发生强度破坏、共振破坏。反拱水垫塘运用时,应控制底板块位移、减少拱圈锁定底板块数,才能使轴力分布在合理范围。     

实验室通风系统风机噪声的综合治理

实验室通风系统在保证良好的室内空气质量的同时,往往会带来一定程度的噪声污染.济南市供排水监测中心综合实验室通风系统对室外环境造成了严重的噪声污染.文章对该实验室通风系统的噪声特性进行了测试与分析,结果表明:位于室外屋顶的风机为主要噪声源;阐述了针对风机噪声采用综合运用隔声罩、阻抗式消声器和隔声包扎等治理措施;提出了使用计算机模拟的方法用于噪声治理措施的选择与评价.项目竣工后,其噪声污染已控制到国家允许标准以下.     

矸石山内部粒径分布规律的实验研究

以阜新海州立井矸石山为原型,通过矸石山相似模拟实验,分析了煤矸石粒径分布特征,在此基础上利用Matlab图像处理功能画取钻孔,实现矸石山实体模型的三维构建。实验结果表明:矸石山主要存在3个区域,分别为分布于矸石山上部区域的小粒径煤矸石、分布于矸石山中部区域的中等粒径煤矸石和分布于矸石山底部的大粒径煤矸石;在区域交界处形成了锯齿状条纹结构,其条纹数量在轨道坡两翼方向上逐渐减少;同时受不同粒径煤矸石分布区域的影响,矸石山整体表现为中上部区域有较大的容重,周边位置容重相对较小。     

Al—12.5Ti混合粉的机械合金化

通过Ｘ射线衍射、扫描电子显微镜及透射电子显微镜方法，观察了Ａｌ－１２．５Ｔｉ混合粉在机械合金化过程中粒度、形貌、显微结构及相的变化．机械合金化扩展了Ｔｉ在Ａｌ中的固溶度，最终形成了纳米晶过饱和固溶体．经真空退火后，Ａｌ基体上析出Ａｌ３Ｔｉ相．     

微旋流器组并联配置性能对比:U-U型与Z-Z型

引言工程实践中,在满足分离精度的同时还要保证其处理能力,就需要采用多个微旋流器进行并联配置[1-3]。因此微旋流器组并联配置是工程放大应用的必要手段[4-5]。微旋流器组直线状并联配置方式有U-U型、Z-Z型、U-Z(Z-U)型、混合型等方式,如图1所示。在理想条件下,微旋流器组的性能线性叠加,即分离精度与单个微旋流器相同,处理能力是所有微旋流器的总和[6-7]。然而这种线性关系很难得到,其主要原因可能是微旋流器组内存在一个分     

采用高效塔盘和填料综合成组技术改造催化主分馏塔

针对催化分馏塔的工艺特点，在不改变塔体的基础上，提出了ADV高效塔盘和SP规整填料的综合成组技术，并应用该技术时塔内件进行改造，实现了催化主分馏塔的扩能及综合性能的完善。与改造前相比，改造后的催化主分馏塔处理能力增大，操作弹性提高，压降减小，分离效率提高，能耗降低；消除了操作过程中的瓶颈，保证了汽油降烯烃的要求。     

Pd@C3N4 nanocatalyst for highly efficient hydrogen storage system based on potassium bicarbonate/formate

Formate/bicarbonate system has several desirable properties such as noncorrosive and nonirritating nature, as well as facile handling, which make it an attractive candidate for a safe, reversible hydrogen storage material. Herein, Pd nanoparticles supported on mesoporous graphitic carbon nitride (mpg‐C₃N₄) for formate‐based reversible hydrogen storage is reported. The as‐developed Pd/mpg‐C₃N₄ material was shown to be a superior catalyst for the hydrogenation of high concentrations of bicarbonate to formate under mild conditions. The effects of reaction temperature, H₂ pressure, and bicarbonate concentration on the hydrogenation of bicarbonate to formate were investigated. The catalytic performance remained steady with high activity up to six hydrogenation cycles. The interaction between mpg‐C₃N₄ and Pd nanoparticles and the concerted effects of the nitrogen species located at mpg‐C₃N₄ and bicarbonate played a synergetic role in the enhancement of the performance of the catalyst for hydrogenation. © 2016 American Institute of Chemical Engineers AIChE J, 62: 2410–2418, 2016