Cover Image,Volume 66, Issue 3

The cover image, by Katia Sparnacci et al., is based on the Research Article High temperature surface neutralization process with random copolymers for block copolymer self‐assembly, DOI: 10.1002/pi.5285 .

     

WSN Deployment and Localization Using a Mobile Agent

To address the problem the sensors were typically deployed in fixed positions, but the robots can be used to calibrate, deploy and maintain the surrounding wireless sensor network (WSN) in disaster relief applications, a novel framework was proposed to obtain a wide coverage of the unknown environment by the sensors, which can help the robot during the disaster recovery activities, for the concurrent deployment and localization of a WSN by means of a mobile robot. During the mission, the robot explored an unknown environment, and was equipped with both proprioceptive sensors, range finders and wireless antennas. Moreover, the robot carried a set of nodes, and it can deploy them while exploring the unknown environment. Variou experimental results showd the proposed algorithm can outperform trilateration method in unknown environment exploration and network coverage problems.     

Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition

The ever‐growing number of pathogenic bacteria resistant to treatment with antibiotics call for the development of novel compounds with as‐yet unexplored modes of action. Here, we demonstrate the in vivo antibacterial activity of carba‐α‐d ‐glucosamine (CGlcN). In this mode of action study, we provide evidence that CGlcN‐mediated growth inhibition is due to glmS ribozyme activation, and we demonstrate that CGlcN hijacks an endogenous activation pathway, hence utilizing a prodrug mechanism. This is the first report describing antibacterial activity mediated by activating the self‐cleaving properties of a ribozyme. Our results open the path towards a compound class with an entirely novel and distinct molecular mechanism.     

Inherent safety key performance indicators for hydrogen storage systems

The expected inherent safety performance of hydrogen storage technologies was investigated. Reference schemes were defined for alternative processes proposed for hydrogen storage, and several storage potentialities were considered. The expected safety performance of alternative process technologies was explored estimating key performance indicators based on consequence assessment and credit factors of possible loss of containment events. The results indicated that the potential hazard is always lower for the innovative technologies proposed for hydrogen storage, as metal or complex hydrides. This derived mainly from the application of the inherent safety principles of "substitution" and "moderation", since in these processes hydrogen is stored as a less hazardous hydride. However, the results also evidenced that in the perspective of an industrial implementation of these technologies, the reliability of the auxiliary equipment will be a critical issue to be addressed.     

Thermally Reduced Graphene Oxide Nanohybrids of Chiral Functional Naphthalenediimides for Prostate Cancer Cells Bioimaging

This study reports on the supramolecular assemblies formed between planar carbon systems (PCSs) such as thermally reduced graphene oxide (TRGO) and its small‐molecule model system coronene and a series of d ‐ and l ‐α amino acid derivatized naphthalenediimides (NDIs) where the halogen substituents (X = F, Cl, Br, I) are varied systematically. Confocal fluorescence microscopy of NDIs, NDI?coronene, and NDI?TRGO complexes is performed proving the uptake and stability of such complexes in the cellular environment and suggesting their potential as prostate cancer imaging agents. ¹H NMR and UV–vis spectroscopy studies support the formation of charge transfer complexes whereby the increasing polarizability and general electronegativity of the aryl halide substituted at the NDI periphery influence the magnitude of the association constants in the ground state between NDI and coronene. Complexation between NDIs and PCSs also results in stable photoexcited assemblies within the solution (coronene) as well as the dispersed phased (TRGO). Fluorescence emission titrations and 2‐photon time correlated single photon counting measurements suggest the existence of dynamic quenching mechanisms upon the excitation of the fluorophore in the presence of the carbon substrates, as these methods are sensitive proves for the subtle changes in the NDI environment. The series of halogenated species used exerts supramolecular control over the degree of surface assembly on the TRGO and over the interactions with the coronene molecule, and this is of relevance to the assembly of future biosensing platforms as these materials can both be viewed as congeners of graphene. Finally, MTT assays carried out in PC‐3 cells demonstrate that the stable noncovalent functionalization of TRGO and coronene with either l or d NDIs remarkably improves the cellular viability in the presence of such graphene‐like materials. These phenomena are of particular relevance for the understanding of the direct donor–acceptor interactions in solutions which govern the design of nanomaterials with future biosensing and bioimaging applications.     

Design methodology for common‐mode stability of OTA‐based gyrators

This paper presents a design methodology for common‐mode (CM) stability of operational transconductance amplifier (OTA)‐based gyrators. The topology of g_m ? C active inductors is briefly reviewed. Subsequently, a comprehensive mathematical analysis on the CM stability of OTA‐based gyrators is presented. Sufficient requirements for the gyrator's CM stability, which easily can be considered during the design process of common‐mode feedback (CMFB) amplifiers, are defined. Based on these stability requirements, a design methodology and a design procedure are proposed. Finally, in order to validate the proposed procedure, a resonator with 20 MHz resonance frequency and a quality factor of 20 is fabricated with UMC 180 nm complementary metal‐oxide‐semiconductor technology, and its CM stability is examined. Copyright © 2015 John Wiley & Sons, Ltd.     

Surface studies of aminoferrocene derivatives on gold: electrochemical sensors for chemical warfare agents

The cystamine conjugate [(BocNH)Fc(CO)CSA]2 was prepared by coupling cystamine with the N-protected ferrocene amino acid derivative BocHN-Fc-COOH and was fully characterized by spectroscopic methods and by single-crystal X-ray diffraction. The cystamine conjugate forms films on gold substrates, which upon deprotection of the amino group, react with chemical warfare agent (CWA) mimics, upon which the redox properties of the Fc group are affected significantly. Cyclic voltammetry shows 50(5) mV anodic shifts of the Fc redox potentials after exposure to EtSCH2CH2Cl, a simulant for sulfur mustard HD (MA), and (NC)(EtO)2P(O), a simulant for nerve agent Tabun (NA). Exposure to MA and NA causes an increase in 2.3 and 4.5 ng mass, respectively, in QCM which indicates ca. 70% efficiency in Boc-deprotection. Ellipsometry measured a film thickness increase from 6(+/-1) A for the deprotected film to 10(+/-4) A for the film modified with MA and to 7(+/-2) A for the film modified with NA. AFM measurements show changes in the thickness and morphology of the film after reaction with MA and NA. The surfaces were analyzed by X-ray photoelectron spectroscopy (XPS) and clearly show the attachment of the cystamine conjugate on the surface and its reaction with CWA mimics.     

Heat Flow Calorimetry of Propellants – Effects of Sample Preparation and Measuring Conditions

Isothermal microcalorimetry measurements were performed on the double base ball propellant K 6210. The influence of different sample preparation techniques and measuring conditions is discussed. The most important parameter is the atmosphere above the propellant. If air is replaced by nitrogen a reduction of primary effects can be observed. A replacement by oxygen leads to a complete different decomposition reaction. Comparable effects are achieved when the ampoules are only filled to 25%. In this case oxidation reactions can be observed. Also using ampoules that are not tightly closed changes the decomposition reaction. All experiments were accompanied by stabiliser analyses (HPLC) that demonstrate the different decomposition reactions as well. Changing the temperature but leaving the sample preparation and measurement conditions unchanged heat flow curves are observed that are similar in shape. That means that the decomposition reactions are comparably activated. Reducing the volume to lower the sample amount is not possible by adding glass balls because absorption/desorption reactions cover the first part of the decomposition reaction. If a glass rod is taken there is no change in the shape of the curve.