Special Issue on Computer Aided Engineering in Honor of Professor Steven J. Fenves

Engineering with Computers -     

Characterization of the temperature sensitivity of gain and recombination mechanisms in 1.3-/spl mu/m AlGaInAs MQW lasers

The potential of 1.3-/spl mu/m AlGaInAs multiple quantum-well (MQW) laser diodes for uncooled operation in high-speed optical communication systems is experimentally evaluated by characterizing the temperature dependence of key parameters such as the threshold current, transparency current density, optical gain and carrier lifetime. Detailed measurements performed in the 20/spl deg/C-100/spl deg/C temperature range indicate a localized T/sub 0/ value of 68 K at 98/spl deg/C for a device with a 2.8 /spl mu/m ridge width and 700-/spl mu/m cavity length. The transparency current density is measured for temperatures from 20/spl deg/C to 60/spl deg/C and found to increase at a rate of 7.7 A/spl middot/cm/sup -2//spl middot/ /spl deg/C/sup -1/. Optical gain characterizations show that the peak modal gain at threshold is independent of temperature, whereas the differential gain decreases linearly with temperature at a rate of 3/spl times/10/sup -4/ A/sup -1//spl middot//spl deg/C/sup -1/. The differential carrier lifetime is determined from electrical impedance measurements and found to decrease with temperature. From the measured carrier lifetime we derive the monomolecular ( A), radiative (B), and nonradiative Auger (C) recombination coefficients and determine their temperature dependence in the 20/spl deg/C-80/spl deg/C range. Our study shows that A is temperature independent, B decreases with temperature, and C exhibits a less pronounced increase with temperature. The experimental observations are discussed and compared with theoretical predictions and measurements performed on other material systems.     

Segregation of spermatozoa within sperm storage tubules of fowl and turkey hens

In avian species, spermatozoa reside in the oviduct for prolonged periods in specialized structures known as sperm storage tubules, but little is known about the relative distribution of spermatozoa in these tubules after successive inseminations by different males. The staining efficacies of various fluorescent dyes for fowl and turkey spermatozoa were evaluated to investigate one proposed mechanism of sperm competition. Hens were then inseminated at different intervals with stained and unstained spermatozoa to observe the spatial distribution of spermatozoa within the storage tubules. Several novel fluorescent lipophilic tracers that successfully stain mammalian spermatozoa either did not stain fowl or turkey spermatozoa, or greatly impaired sperm motility. In contrast, Hoechst 33342 readily stained sperm nuclei (fowl: 25 nmol l-1; turkey: 77 nmol l-1) within 4 h without inhibiting sperm motility, or affecting fertility or the hatching ability of the eggs. Hens were tandemly inseminated with equal numbers of stained or unstained spermatozoa at 24 h intervals and were killed 24 h after the final insemination to study sperm entry and storage within the tubules. Oviductal mucosa containing sperm storage tubules was removed, and individual tubules were classified as containing stained spermatozoa, unstained spermatozoa, a mixture of stained and unstained spermatozoa, or as not containing spermatozoa. Results from the present study indicate that spermatozoa from two different inseminations generally segregate into different storage tubules in both fowl and turkey hens. Storage tubules containing mixed populations of spermatozoa were found in only 4% of fowl and 12% of turkey storage tubules examined. Thus, the mechanism of last-male precedence does not appear to be due to the stratification of spermatozoa within the tubules.     

Developing Dementia Prevalence Rates Among Latinos: A Locally-Attuned, Data-Based, Service Planning Tool

The prevalence of Alzheimer’s disease and associated disorders (ADAD) determines the level of need for ADAD services. Since services need to be made available locally, therefore local—rather than national—prevalence levels are instrumental in guiding services to meet these emerging needs. This study employed a three-stage methodology to establish Latino ADAD prevalence estimates within San Diego and Imperial Counties in California for the period 2000–2050. The first stage involved the development of a working algorithm for the ADAD estimates combining existing demographic data with small-scale prevalence data from recent clinical studies of ADAD among Latinos. Results from this algorithm projected an 1,123 % increase of ADAD impacted Latinos in San Diego County and 1,213 % in Imperial County by 2050. Stage two encompassed examining the face validity and efficacy of these projections at the local provider level through focus groups. This stage confirmed the findings that a large sector of the local Latino ADAD community had a profile of lower education and socioeconomic status, more traditional cultural orientations, and high rates of diabetes mellitus and vascular disease which resulted in earlier onset of ADAD. The third stage in the methodology employed a 36-month observational window tracking the impact of the local ADAD prevalence estimates on various programs. The authors of this study argue for the efficacy, and external validity of the methodology employed to define local ADAD prevalence rates for other ethnic groups. This knowledge will promote local communities in developing culturally competent services for their own diverse local service areas based on local estimates.     

EEG evidence of stimulus-directed response dynamics in human somatosensory cortex

Dense multichannel recordings of scalp electroencephalogram (EEG) were obtained in the vicinity of primary somatosensory cortex, time-locked to repetitive vibrotactile stimulation of sites on the right index finger of a single human subject. Frequency-domain analysis of cross-trial averages revealed prominent 'driving' responses in the EEG at the frequency of stimulation, which under specific stimulus conditions displayed pronounced changes in amplitude and topographic organization over brief (4 s) durations of stimulus exposure. The changes were systematic and physiologically coherent, evolving toward driving-response topographies observed in the same subject in conjunction with periodic microstimulation of single mechanoreceptive afferents whose receptive fields occupied corresponding positions on the digit. This dynamic process was orderly and reproducible, and could be controlled by manipulating factors such as the amplitude, frequency, and temporal spacing of the stimuli. The results are tentatively interpreted in light of a previously proposed neurophysiological model of stimulus-driven response plasticity in mammalian somatosensory cortex.     

Undermining the Corrective Effects of Media‐Based Political Fact Checking? The Role of Contextual Cues and Naïve Theory

Media‐based fact checking contributes to more accurate political knowledge, but its corrective effects are limited. We argue that biographical information included in a corrective message, which is often unrelated to the inaccurate claim itself, can activate misperception‐congruent naïve theories, increasing confidence in a misperception's plausibility and inducing skepticism toward denials. Resistance to corrections occurs regardless of initial belief accuracy, but the effect is strongest among those who find the contextual information objectionable or threatening. We test these claims using an online survey‐embedded experiment (N = 750) conducted in the wake of the controversy over the proposed Islamic cultural center in New York City near the site of the 9/11 attacks, and find support for our predictions. Theoretical and practical implications are discussed.     

Retrospective analysis of the Beijing family of Mycobacterium tuberculosis in preserved lung tissues

Direct repeat spoligotyping of 85 paraffin-embedded lung biopsies was used to investigated the occurrence around Beijing of the Beijing family of Mycobacterium tuberculosis. Samples ranged in time from 1956 to 1990. Hybridization patterns were found with 49 (58%) samples, and 45 (92%) produced typical Beijing family patterns extending over the 34-year period.     

The nature of the blue species formed when 1,1-diphenylethylene chemisorbs and reacts on acidic solids

The blue species obtained when 1,1-diphenylethylene chemisorbs on highly acidic solids arises from a very minor dimerization reaction where a less stable canonical form of the initial carbenium ion adds to Φ₂C=CH₂ (Φ=phenyl). Proton loss followed by H^- ion abstraction from the resulting olefin then affords a highly conjugated ion as the blue species. This revised version was published online in July 2006 with corrections to the Cover Date.