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71.
Prof. Dr. Robert Winter Institut für Wirtschaftsinformatik Universität St. Gallen St. Gallen Schweiz Robert.Winter@unisg.ch Prof. Dr. Richard Baskerville Georgia State University Atlanta Georgia USA Baskerville@acm.org 《WIRTSCHAFTSINFORMATIK》2009,51(3):312-313
Ohne Zusammenfassung
This article is also available in English via and : Winter R, Baskerville R (2009) BISE – Call for Papers, Issue 5/2010, Science of Business and Information Systems Engineering.
Bus Inf Syst Eng. doi: 10.1007/s12599-009-0047-2. 相似文献
72.
Georgia M. Kapitsaki Dimitrios A. Kateros George N. Prezerakos Iakovos S. Venieris 《Information and Software Technology》2009,51(8):1244-1260
Context-awareness constitutes an essential aspect of services, especially when interaction with end-users is involved. In this paper a solution for the context-aware development of web applications consisting of web services is presented. The methodology proposes a model based approach and advocates in favour of a complete separation of the web application functionality from the context adaptation at all development phases (analysis, design, implementation). In essence, context adaptation takes place on top of and is transparent to the web application business functionality. Starting from UML diagrams of independent web services and respective UML context models, our approach can produce a functional composite context-aware application. At execution level this independence is maintained through an adaptation framework based on message interception. 相似文献
73.
Georgia Arentz Florian Weiland Martin K. Oehler Peter Hoffmann 《Proteomics. Clinical applications》2015,9(3-4):277-288
Difference gel electrophoresis enables the accurate quantification of changes in the proteome including combinations of PTMs and protein isoform expression. Here, we review recent advances in study design, image acquisition, and statistical analysis. We also compare DIGE to established and emerging mass spectrometric analysis technologies. Despite these recent advances in MS and the still unsolved limitations of 2DE to map hydrophobic, high molecular weight proteins with extreme pIs, DIGE remains the most comprehensive top-down method to study changes in abundance of intact proteins. 相似文献
74.
Georgia Penido Safe Claudionor Coelho Jr. Luiz Filipe M. Vieira Celina Gomes Do Val Jose Augusto Nacif Antonio Otavio Fernandes 《International Journal on Software Tools for Technology Transfer (STTT)》2012,14(1):95-108
Functional verification is “the” major design-phase bottleneck for silicon productivity. Since functional verification is
an NP-complete problem, it relies on a large number of heuristics with associated parameters (engines). With the advent of
parallel processing, formal verification can be optimized by selecting the best n engines to run in parallel, increasing the chance of reaching successful termination of the verification task. In this paper,
we will present a methodology to build engine estimators based on structural metrics and to select n engines to run in parallel. The methodology considers both engines’ estimated performance and engines’ correlation. Results
confirmed that the methodology can be a very quick selection mechanism for parallelization of engines in order to increase
the chance of running the best engines to solve the problem. 相似文献
75.
On the stabilization of feedforward systems with bounded control 总被引:2,自引:0,他引:2
For the global asymptotic stabilization of nonlinear—controllable in the first approximation—cascades consisting of a globally asymptotically—locally exponentially stable system driving a stable system, a Lyapunov-like design is proposed. This yields (bounded) control laws, where the control magnitude can be chosen arbitrarily large. This result provides an alternative to classical forwarding. 相似文献
76.
Marco Brünjes Georgia Sourkouni‐Argirusi Andreas Kirschning 《Advanced Synthesis \u0026amp; Catalysis》2003,345(5):635-642
A polymer‐bound reagent for the efficient oxidation of primary alcohols to aldehydes and secondary alcohols to ketones in the presence of a catalytic amount of 2,2,6,6‐tetramethyl‐1‐piperidinyloxyl (TEMPO) is described. The oxidation process is particular mild and allows one to prepare aldehydes with α‐chirality without racemization. This also includes the synthesis of α‐aminoaldehydes. In most cases, work‐up of this heavy metal‐free oxidation is achieved by simple filtration followed by removal of the solvent. Insight into the role of the bromate(I) anion in the oxidation process was gained from the TEMPO‐mediated oxidation of benzaldehyde in the presence of the hypochlorite anion loaded on an anion exchange resin. 相似文献
77.
Kayla Kauffman Courtney S. Werner Georgia Titcomb Michelle Pender Jean Yves Rabezara James P. Herrera Julie Teresa Shapiro Alma Solis Voahangy Soarimalala Pablo Tortosa Randall Kramer James Moody Peter J. Mucha Charles Nunn 《Journal of the Royal Society Interface》2022,19(186)
Social and spatial network analysis is an important approach for investigating infectious disease transmission, especially for pathogens transmitted directly between individuals or via environmental reservoirs. Given the diversity of ways to construct networks, however, it remains unclear how well networks constructed from different data types effectively capture transmission potential. We used empirical networks from a population in rural Madagascar to compare social network survey and spatial data-based networks of the same individuals. Close contact and environmental pathogen transmission pathways were modelled with the spatial data. We found that naming social partners during the surveys predicted higher close-contact rates and the proportion of environmental overlap on the spatial data-based networks. The spatial networks captured many strong and weak connections that were missed using social network surveys alone. Across networks, we found weak correlations among centrality measures (a proxy for superspreading potential). We conclude that social network surveys provide important scaffolding for understanding disease transmission pathways but miss contact-specific heterogeneities revealed by spatial data. Our analyses also highlight that the superspreading potential of individuals may vary across transmission modes. We provide detailed methods to construct networks for close-contact transmission pathogens when not all individuals simultaneously wear GPS trackers. 相似文献
78.
Zoumpopoulou G Foligne B Christodoulou K Grangette C Pot B Tsakalidou E 《International journal of food microbiology》2008,121(1):18-26
Lactobacillus fermentum ACA-DC 179, Lactobacillus plantarum ACA-DC 287 and Streptococcus macedonicus ACA-DC 198 were studied for their probiotic potential. Firstly, strains were screened for antimicrobial activity towards a broad range of target strains, including lactic acid bacteria, food spoilage and pathogenic bacteria. L. fermentum ACA-DC 179 was active against five streptococci, including the two pathogenic strains Streptococcus oralis LMG 14532T and Streptococcus pneumoniae LMG 14545T. S. macedonicus ACA-DC 198 was active against the majority of the strains tested, including not only lactic acid bacteria but also many food spoilage or pathogenic species. The three potential probiotic strains were found to survive variably at pH 2.5 and were unaffected by bile salts. Only S. macedonicus ACA-DC 198 exhibited bile salt hydrolase activity, while none of the strains was haemolytic. Moreover, strains exhibited variable susceptibility towards commonly used antibiotics. L. plantarum ACA-DC 287 and S. macedonicus ACA-DC 198 induced the secretion of the pro-inflammatory cytokines IL-12, IFN-gamma and TNF-alpha by human peripheral blood mononuclear cells. Also elevated levels of the anti-inflammatory IL-10 were observed with L. fermentum ACA-DC 179. This strain consequently was found to significantly reduce colitis in a TNBS-induced colitis mouse model. Furthermore, L. fermentum ACA-DC 179 was successfully applied in an experimental Salmonella-infection mouse model. To conclude, strain L. fermentum ACA-DC 179 possesses desirable probiotic properties, such as antimicrobial activity and immunomodulation in vitro, which were confirmed in vivo by the use of animal models. 相似文献
79.
Glutathione S-transferases (GSTs) are a heterogeneous family of enzymes that catalyse the conjugation of glutathione (GSH) to electrophilic sites on a variety of hydrophobic substrates. In the present study three amino acid residues (Trp12, Phe35 and Ile118) of the xenobiotic binding site (H-site) of maize GST I were altered in order to evaluate their contribution to substrate binding and catalysis. These residues are not conserved and hence may affect substrate specificity and/or product dissociation. The results demonstrate that these residues are important structural moieties that modulate an enzyme's catalytic efficiency and specificity. Phe35 and Ile118 also participate in k(cat) regulation by affecting the rate-limiting step of the catalytic reaction. The effect of temperature on the catalytic activity of the wild-type and mutant enzymes was also investigated. Biphasic Arrhenius and Eyring plots for the wild-type enzyme showed an apparent transition temperature at 35 degrees C, which seems to be the result of a change in the rate-limiting step of the catalytic reaction. Thermodynamic analysis of the activity data showed that the activation energy increases at low temperatures, whereas the entropy change seems to be the main determinant that contributes to the rate-limiting step at high temperatures. 相似文献
80.
The occurrence of five endocrine-disrupting compounds (EDCs), namely 4-n-nonylphenol (4-n-NP), nonylphenol monoethoxylate (NP1EO), nonylphenol diethoxylate (NP2EO), triclosan (TCS) and bisphenol A (BPA), was assessed in the raw, treated wastewater and sewage sludge of eight sewage treatment plants (STPs) in Greece. The analytes were extracted by solid-phase extraction (dissolved phase) or sonication (solid phase). Qualitative and quantitative analyses were performed by gas chromatography-mass spectrometry (GC-MS). The average concentrations in the raw and treated wastewater ranged from 0.23 (4-n-NP) to 5.76microgL(-1) (NP1EO) and from 0.15 (BPA) to 1.84microgL(-1) (NP2EO), respectively. A great part of the detected EDCs was sorbed on suspended solids. In sewage sludge, the average concentrations ranged between 0.17 (4-n-NP) and 12.3microgg(-1)dw (NP1EO). Analysis of daily mass flows in STP of Athens showed that, with the exception of 4-n-NP, all other EDCs were significantly removed (>85%) during wastewater treatment. Regarding the fate of these compounds, a significant part ranging from 45% (for TCS) to more than 70% (for NP1EO, NP2EO and BPA) was transformed by abiotic or biotic mechanisms, while the rest was accumulated in sewage sludge or disposed to the environment via the effluents. Calculation of risk quotients showed the existence of possible threat due to the presence of certain EDCs in treated wastewater and sludge. 相似文献