Use and Mis-Use of Measurement Scales in City Planning

By developing measurement scales the city planner can promote his long-run interest in integrating urban knowledge and his short-run interest in making valid analyses of specific problems. But the construction of measurement scales is not a random process and must be conducted according to logical rules. Inadequacies in current city planning scales are largely attributable to the lack of adherence to these rules. Housing quality scales, the most common measurement device in city planning, reveal some of the difficulties that lead to deficiencies in our measurement. The outlook is far from gloomy. Experience from other fields in index number construction, the use of scalograms, and factor analysis can Open up many promising avenues for city planning measurement.     

Enantiospecific Synthesis and Cytotoxicity Evaluation of Oximidine II Analogues

Analogues of the anticancer natural product oximidine II were prepared and evaluated for cytotoxicity. One analogue of oximidine II that carries a C15 allylic amide side chain as well as two analogues with C15 vinyl sulfone side chains were found to lack cytotoxicity against the cancer cell line SK‐Mel‐5, thereby confirming the necessity of the C15 enamide side chain of oximidine II for cytotoxicity. Four analogues, designed by comparative molecular similarity index analysis (CoMSIA), that feature a less complex macrolactone scaffold were prepared and tested. The two analogues carrying a C15 vinyl sulfone group and the two analogues with a C15 oximidine II enamide side chain showed weak cytotoxicity against the SK‐Mel‐5 cell line and other cell lines, indicating that the designed simplified macrocycles cannot replace the oximidine II macrocycle.     

Optimization of segmented constrained layer damping with mathematical programming using strain energy analysis and modal data

A new method for enhancement of damping capabilities of segmented constrained layer damping material is proposed. Constrained layer damping has been extensively used since many years to damp flexural vibrations. The shear deformation occurring in the viscoelastic core is mainly responsible for the dissipation of energy. Cutting both the constraining and the constrained layer, which leads to segmentation, increases the shear deformation at that position. This phenomenon is called edge effect. A two-dimensional model of a cantilever beam has been realized for further investigations. An optimization algorithm using mathematical programming is developed in order to identify a cuts arrangement that optimizes the loss factor. The damping efficiency is estimated using the modal strain energy method. The Nelder–Mead simplex method is used to find the best distribution of cuts. In order to take into account geometrical limitations, the exterior point penalty method is used to transform the constrained objective function into an unconstrained objective function. As the optimization problem is not convex, a modal analysis is performed at each mode in order to identify initial cuts positions that lead to a global minimum. Over a large frequency range, the algorithm is able to identify a distribution of cuts that optimizes the loss factor of each mode under consideration.     

Applied Regression Analysis (2nd Ed.)

We describe a diagnostic method for assessing the degree to which individual cases and groups of cases influence the Box-Cox likelihood estimate of the transformation parameter for the response variable in linear regression models. We compare the method to a method proposed by Atkinson (1982) and sketch the extension to explanatory variables. We present two examples.     

Influence of the Cooling Temperature on the Mechanical Behavior of an Oxidized Self-Healing Ceramic Matrix Composite

Composites made of ceramic for both fibers and matrix are aimed at being used in aerospace applications, which means being submitted to mechanical stresses at high temperatures in oxidizing and corrosive environments for long durations. The oxidation/corrosion resistance of these materials is linked to their ability to self-heal by creating an oxide phase which can restrict the access of the oxygen into the bulk of the material. During thermomechanical cycles, the distribution of O₂ inside the material as well as the distribution and the state of the liquid oxides will undergo some modifications. A specific test has been conceived and performed in order to evidence the influence of the viscosity of this oxide on the mechanical properties of the material. Results have shown that the stiffening which is observed seems to be proportional to the increase in the viscosity of the sealing oxide, in conjunction with the decrease in the temperature.     

Analogical reconstruction of the probability knowledge of Zimbabwean female secondary school students

Abstract

Analogies were used to facilitate reconstructing the probability knowledge of 54 culturally diverse, female, Zimbabwean secondary school students in cases where there were misconceptions in their comprehension of probability. Ten contextually appropriate misconception‐prone target situations were generated, together with their conceptually analogous counterparts, known as source or anchoring situations. The source analogues were designed to draw out those areas where student beliefs agreed with accepted mathematical theory. Students’ responses to the target situations indicated that probability misconceptions were common and that the source analogues were effective in providing anchors for mathematically correct ideas. The participants were interviewed and knowledge reconstruction was attempted using the source analogues. A success rate of 0.88 was achieved. Testing after one month indicated a stability rate of 0.82 for the reconstructed probability knowledge.     

Biomimetic hydroxyapatite coating on glass coverslips for the assay of osteoclast activity in vitro

The osteoclast (OC) is the cell type responsible for the resorption of bone. The activity of this cell is important in the aetiology of a large number of skeletal pathologies, and also for the biocompatibility and osseointegration of orthopaedic implant materials. OC mediated acid hydrolysis of calcium phosphate from the bone matrix offers a prime means of studying the biology and activity of this cell type. We have developed a method of coating glass coverslips with a hydroxyapatite (HA)-like mineral, using a biomimetic approach. Hydroxylation followed by formation of a self assembled monolayer (SAM) using the surfactant triethoxysilylpropyl succinic anhydride (TESPSA), allowed biomimetic deposition of HA-like mineral from a simulated body fluid (SBF). The biocompatibility of the TESPSA SAM-HA coated glass coverslips was tested by culturing human mature OC present in samples of giant cell tumour of bone (GCT). Parameters of OC activity were assayed, including F-actin ring formation, release of calcium and formation of osteoclastic resorption pits, confirming that OC were able to attach to and resorb the coated surface. This approach for the preparation of HA coatings on glass coverslips could have wide applicability for the study of osteoclast behaviour in vitro. Gerald J. Atkins and Peter Majewski share senior author status.     

The association between price of regular-grade gasoline and injury and mortality rates among occupants involved in motorcycle- and automobile-related motor vehicle collisions

Motorcyclists have been reported to be more likely to die in a motor vehicle collision (MVC) than automobile occupants. With the recent increase in the pump price of gasoline, it has been reported that people are switching to motorcycles as main modes of transportation. This study evaluated the association between motor vehicle collision-related injury and mortality rates and increases in gasoline prices for occupants of automobiles and riders of motorcycles.There were an estimated 1,270,512 motorcycle MVC and 238,390,853 automobile MVC involved occupants in the U.S. from 1992 to 2007. Higher gasoline prices were associated with increased motorcycle-related injuries and deaths; however, this association no longer remained after accounting for changes in the number of registered vehicles.The current study observed that, while the number of injuries and fatalities in motorcycle-related MVCs increase with increasing gasoline price, rates remained largely unchanged. This suggests that the observed increase in motorcycle-related injuries and fatalities with increasing gasoline price is more a factor of the number of motorcycles on the road rather than operator characteristics.