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71.
Milani M Drobne D Tatti F Batani D Poletti G Orsini F Zullini A Zrimec A 《Scanning》2005,27(5):249-253
A novel focused ion beam-based technique is presented for the read-out of microradiographs of Caenorhabditis elegans nematodes generated by soft x-ray contact microscopy (SXCM). In previous studies, the read-out was performed by atomic force microscopy (AFM), but in our work SXCM microradiographs were imaged by scanning ion microscopy (SIM) in a focused ion beam/scanning electron microscope (FIB/SEM). It allows an ad libitum selection of a sample region for gross morphologic to nanometric investigations, with a sequence of imaging and cutting. The FIB/SEM is less sensitive to height variation of the relief, and sectioning makes it possible to analyse the sample further. The SXCM can be coupled to SIM in a more efficient and faster way than to AFM. Scanning ion microscopy is the method of choice for the read-out of microradiographs of small multicellular organisms. 相似文献
72.
Alessandro Guidotti Alessandro Vanelli‐Coralli Tommaso Foggi Giulio Colavolpe Mrius Caus Joan Bas Stefano Cioni Andrea Modenini 《International Journal of Satellite Communications and Networking》2019,37(4):316-330
The integration of satellite and terrestrial networks is a promising solution for extending broadband coverage to areas not connected to a terrestrial infrastructure, as also demonstrated by recent commercial and standardisation endeavours. However, the large delays and Doppler shifts over the satellite channel pose severe technical challenges to traditional terrestrial systems, as long‐term evolution (LTE) or 5G. In this paper, 2 architectures are proposed for a low Earth orbit mega‐constellation realising a satellite‐enabled LTE system, in which the on‐ground LTE entity is either an eNB (Sat‐eNB) or a relay node (Sat‐RN). The impact of satellite channel impairments as large delays and Doppler shifts on LTE PHY/MAC procedures is discussed and assessed. The proposed analysis shows that, while carrier spacings, random access and RN attach procedures do not pose specific issues and hybrid automatic repeat request requires substantial modifications. Moreover, advanced handover procedures will be also required due to the satellites' movement. 相似文献
73.
M. Di Giulio V. Di Valerio D. Bosco E. Marsich A. Cataldi L. Cellini S. Sancilio 《Journal of materials science. Materials in medicine》2018,29(4):36
The molecular mechanisms leading to Streptococcus mitis capability of entering oral cells were investigated in a co-culture of S. mitis and Human Gingival Fibroblasts (HGFs) in the presence of saliva. An innovative colloidal solution based on silver nanoparticles (Chitlac-nAg), a promising device for daily oral care, was added to the experimental system in order to study the effects of silver on the bacterial overgrowth and ability to enter non-phagocytic eukaryotic cells. The entry of bacteria into the eukaryotic cells is mediated by a signalling pathway involving FAK, integrin β1, and the two cytoskeleton proteins vinculin and F-actin, and down-regulated by the presence of saliva both at 3 and 48?h of culture, whereas Chitlac-n Ag exposure seems to influence, by incrementing it, the number of bacteria entering the fibroblasts only at 48?h. The formation of fibrillary extrusion from HGFs and the co-localization of bacteria and silver nanoparticles within the fibroblast vacuoles were also recorded. After longer experimental times (72 and 96?h), the number of S. mitis chains inside gingival cells is reduced, mainly in presence of saliva. The results suggest an escape of bacteria from fibroblasts to restore the microbial balance of the oral cavity. 相似文献
74.
Cellulose Nanocrystals from Lignocellulosic Raw Materials,for Oxygen Barrier Coatings on Food Packaging Films
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Stefano Gazzotti Marco A. Ortenzi Giulio Piva Luciano Piergiovanni 《Packaging Technology and Science》2017,30(10):645-661
Cellulose nanocrystals (CNCs) are unique, renewable top‐down nano particles from which coatings with improved gas barrier properties and new functionalities can be prepared. In this paper, the potential for obtaining such high performing nanocrystals from low‐cost lignocellulosic by‐products or raw materials is proved by a comparison study on CNCs obtained both from cotton linters and kraft pulp, by means of the ammonium persulfate (APS) process. Morphological and chemical characterization of the nanocrystals obtained, as well as the main functional properties of the poly(ethylene terephthalate) coated films, showed quite similar characteristics and performances of CNCs obtained from pure cellulose raw material (cotton linters) and the nanoparticles produced from a potential discard of paper making processes (kraft pulp). In particular, the gas barrier properties of the coating produced with CNCs obtained from kraft pulp were very promising, providing oxygen and carbon dioxide permeability values hundreds of times lower than those of equal thickness in comparison with common barrier synthetic polymers, over a broad range of temperatures. The results obtained are relevant not only for the outstanding performances achieved, but also because they evoke a possible positive example of industrial symbiosis in the packaging field, merging together the requirements and needs of the paper and plastic industries and addressing the way towards a better management of waste and materials. Copyright © 2017 John Wiley & Sons, Ltd. 相似文献
75.
Raffaele Montella Giulio Giunta Giuliano Laccetti Marco Lapegna Carlo Palmieri Carmine Ferraro Valentina Pelliccia Cheol-Ho Hong Ivor Spence Dimitrios S. Nikolopoulos 《International journal of parallel programming》2017,45(5):1142-1163
The astonishing development of diverse and different hardware platforms is twofold: on one side, the challenge for the exascale performance for big data processing and management; on the other side, the mobile and embedded devices for data collection and human machine interaction. This drove to a highly hierarchical evolution of programming models. GVirtuS is the general virtualization system developed in 2009 and firstly introduced in 2010 enabling a completely transparent layer among GPUs and VMs. This paper shows the latest achievements and developments of GVirtuS, now supporting CUDA 6.5, memory management and scheduling. Thanks to the new and improved remoting capabilities, GVirtus now enables GPU sharing among physical and virtual machines based on x86 and ARM CPUs on local workstations, computing clusters and distributed cloud appliances. 相似文献
76.
Studies of the crystallization of poly(ethylene terephthalate) (PET) by d.s.c., both isothermally and non-isothermally, show that the addition of silica causes marked increases in rate at loadings < 1 part filler in 100 parts polymer. At higher loadings the overall rate of crystallization decreases until it becomes less than that of un-nucleated PET. Modified silica, with an alkoxy-coated surface, causes similar but less pronounced changes in rate. The retardation in rate inspite of an increase in the number of spherulites is attributed to an increase in the viscosity of the polymer melt due to strong adsorption onto the silica particles. 相似文献
77.
Hybrid organic-inorganic nanocomposites containing PEO segments linked to an acrylate-methacrylate network were prepared through a dual-curing process, involving photopolymerization and condensation of alkoxysilane groups. A Polyethyleneglycol 600 α,ω diacrylate (PEGDA 600) and a similar oligomer containing a Bisphenol A unit and α,ω methacrylate groups (BEMA 1400) were used. Mixtures of the oligomers together with methacryloyloxypropyltrimethoxysilane (MEMO) and tetraethoxysilane (TEOS) were prepared.The kinetics of the reactions of photopolymerization and condensation was investigated. The conditions suitable for obtaining a complete conversion of both the reactive groups were settled up.The obtained films were perfectly transparent and amorphous. The Tg values of the hybrids were found to increase by increasing the TEOS content and the alkoxysilane groups condensation.TEM analyses indicated the formation of silica phases at a nanometric level; TGA curves revealed a higher thermal stability of the hybrid structures. 相似文献
78.
Quinone‐Fused Pyrazoles through 1,3‐Dipolar Cycloadditions: Synthesis of Tricyclic Scaffolds and in vitro Cytotoxic Activity Evaluation on Glioblastoma Cancer Cells
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Giulio Bertuzzi Simone Crotti Pierpaolo Calandro Bianca Flavia Bonini Ilaria Monaco Erica Locatelli Mariafrancesca Fochi Paolo Zani Elena Strocchi Prof. Andrea Mazzanti Dr. Mario Chiariello Prof. Mauro Comes Franchini 《ChemMedChem》2018,13(17):1744-1750
A novel and straightforward synthesis of highly substituted isoquinoline‐5,8‐dione fused tricyclic pyrazoles is reported. The key step of the synthetic sequence is a regioselective, Ag2CO3 promoted, 1,3‐dipolar cycloaddition of C‐heteroaryl‐N‐aryl nitrilimines and substituted isoquinoline‐5,8‐diones. The broad functional group tolerability and mild reaction conditions were found to be suitable for the preparation of a small library of compounds. These scaffolds were designed to interact with multiple biological residues, and two of them, after brief synthetic elaborations, were analyzed by molecular docking studies as potential anticancer drugs. In vitro studies confirmed the potent anticancer effects, showing promising IC50 values as low as 2.5 μm against three different glioblastoma cell lines. Their cytotoxic activity was finally positively correlated to their ability to inhibit PI3K/mTOR kinases, which are responsible for the regulation of diverse cellular processes in human cancer cells. 相似文献
79.
Campo S Nastasi G D'Ascola A Campo GM Avenoso A Traina P Calatroni A Burrascano E Ferlazzo A Lupidi G Gabbianelli R Falcioni G 《The Science of the total environment》2008,403(1-3):148-153
In order to gain more knowledge on the stress responses of gilhead seabream (Sparus aurata) under extreme conditions, this study investigated the functional properties of the hemoglobin system and globin gene expression under hypoxia and low salinity. The oxygen affinity for the two hemoglobin components present inside the S. aurata erythrocyte was practically identical as was the influence of protons and organic phosphates (Root effect). The quantification of S. aurata hemoglobin fractions performed by HPLC and the data on gene expression of globin chains assayed by PCR indicate that under hypoxia and low salinity there is a change in the ratio between the two different hemoglobin components. The result indicating that the distinct hemoglobins present in S. aurata erythrocyte have almost identical functional properties, does not explain the adaptive response (expression change) following exposure of the animal to hypoxia or low salinity on the basis of their function as oxygen transporter. We hypothesize that other parallel biological functions that the hemoglobin molecule is known to display within the erythrocyte are involved in adaptive molecular mechanisms. The autoxidation-reduction cycle of hemoglobin could be involved in the response to particular living conditions. 相似文献
80.
Monosodium methanearsonate (MSMA) is a commonly used herbicide on golf courses. To investigate the variation in abundance of arsenic (As) after MSMA application, 28 golf course lakes were monitored monthly for one year. The As concentrations varied substantially in and between individual lakes with values up to 124 microg/L (mean=10.9 microg/L, n=336). This is considerably higher than the As concentrations in comparable "non-golf course" lakes (up to 100-times) in the study area. The highest values of As in the lakes were generally observed in the late spring and early summer and corresponded to the intensity of MSMA applications. Arsenic seems to be sequestered by the golf course lake sediments with concentrations as high as 302 mg/kg, which were significantly higher than the 0.1 to 3 mg/kg expected for comparable sediments in central Florida. Arsenic correlates well with Fe in the top 15 cm of the lake sediments suggesting that As is sorbed by hydrous ferric oxides (HFO). As long as conditions are in favour of HFO stability, As is retained in the lake sediments preventing its migration into the Floridan aquifer systems. However, once the loading capacity of the sediment is reached or when as a result of changing physico-chemical conditions HFO may become unstable, As may enter the Floridan aquifer. 相似文献