Mild hypothermia: therapeutic window after experimental cerebral ischemia

The treatment of cerebral ischemia remains a formidable challenge in neuroscience today. Mild hypothermia has been shown to be an effective neuroprotective agent. Despite the great volume of published research, the therapeutic window of mild hypothermia has not been precisely elucidated. Using a model of reversible focal cerebral ischemia in the rat, this study was undertaken to define the optimal duration of hypothermic application and the maximal postischemic delay in hypothermic application before which optimal therapeutic effect is noted. Focal ischemia was induced by temporary occlusion of the middle cerebral artery and both carotid arteries in Sprague-Dawley rats for a period of 3 hours. In the first study, mild hypothermia (32-33 degrees C) was induced at the onset of ischemia in four groups of rats for varying lengths of time ranging from 1 to 4 hours. The animals were killed after 3 days, and their brains were sliced and stained. Infarcted volume was measured using a computerized image analyzer. The infarct volumes were 211 +/- 4.5, 214.2 +/- 8.0, 199.5 +/- 5.3, 171.3 +/- 9.1, and 169.8 +/- 6.5 mm3 (mean +/- standard error of the mean, n = 6 per group) for the control, 1-hour, 2-hour, 3-hour, and 4-hour groups, respectively. On the basis of the results from the above study, a 3-hour duration of hypothermia was then applied to animals at 0, 15, 30, or 45 minutes after the ischemic onset. The volumes of infarction for these four respective groups were: 171.3 +/- 9.1, 173 +/- 5.7, 179.3 +/- 5.2, and 206.2 +/- 8.4 mm3 (mean +/- standard error of the mean, n = 6 per group). These results demonstrated that optimal duration of mild hypothermia was at least 3 hours (P < 0.001) when applied within the first 30 minutes after the onset of ischemia (P < 0.001).     

EC与~（99m）Tc－GH之间的配体交换反应动力学研究

实验表明，ＥＣ浓度与配体交换反应速度常数无关，体系的ｐＨ值对速度常数和９９ｍＴｃ－ＥＣ的标记率影响较大。测定并计算了不同ｐＨ值的交换反应速度常数。结果表明，为保证用配体交换法制备９９ｍｃ－ＥＣ时９９ｍｃ－ＥＣ的标记率大于９０％，体系的ｐＨ值必须≥８。     

An institution theory of formal meta-modelling in graphically extended BNF

Meta-modelling plays an important role in model driven software development.In this paper,a graphic extension of BNF (GEBNF) is proposed to define the abstract syntax of graphic modelling languages.Fro...     

转炉煤气回收和放散自动控制系统改进

针对在煤气回收和放散调试过程中发现的问题,通过改进转炉煤气回收和放散控制系统,增加气动三通阀控制联锁信号,保证放散的高度可靠性和煤气自动回收的高度安全性。     

基于USB电源的智能风扇控制技术

介绍基于计算机USB电源的智能风扇控制技术。     

谈信息资源管理软件的开发及利用

文章重点阐述了在高职院校信息资源管理艰难的大环境下,我院信息资源管理软件开发使用的环境及过程,重点论述了管理软件的具有的特色及使用过程中遇到的问题。     

A data access framework for service-oriented rich clients

Facilitated by the SOA and new Web technologies, Service-Oriented Rich Clients (SORCs) compose various Web-delivered services in Web browser to create new applications. The SORCs support client-side data storage and manipulation and provide more features than traditional thin clients. However, the SORCs might suffer from data access issues, mainly due to both client-side incompatible data sources and server-side improper or even undesirable cache strategies. Addressing the data access issues, this paper proposes a data access framework for SORCs. The main contributions of this paper are as follows. First, the framework makes the SORCs accommodate heterogeneous local storage solutions and diverse Web browsers properly. The framework abstracts the underlying details of different local storages and selects the most proper data sources for current SORC in use. Secondly, the framework provides a cache mechanism, which supports client-side customized cache strategies. An adaptive technique for the strategies is also proposed to adjust cache strategies based on users?? historical actions to achieve better performance.     

一种新的SAR图像斜距多普勒定位模型的直接解法

斜距多普勒定位模型是实现SAR图像无控制点定位的基本模型,因此如何高效准确地获得RD方程组的解成为实现SAR图像无控制点几何定位的根本问题,也是实现SAR自动图像定位的关键。首先利用地固坐标系下目标速度为零的特性,简化RD模型并整理为一元四次方程,然后利用一元四次方程求根方法,推导出斜距多普勒定位模型的明确数学解析解,并与常用的数值迭代求解方法进行比较分析,仿真结果验证了推导的正确性。新解法具有无需设置初始值,易于编程实现,鲁棒性高的特点。     

OPEN XML文档数字签名的C#实现

针对电子文档的安全性问题,分析了文档的各种数字签名情况,设计了一种能够完成多种签名方法,且能全面验证签名的文档签名系统。系统采用C#编程,从而提高了电子文档的安全性。