一起110kV电容式电压互感器二次零序电压异常波动故障分析

本文针对一起110kV电容式电压互感器二次零序电压异常波动故障进行分析,通过查看现场故障录波波形、检查二次电压回路、电压互感器本体状况,最终查明故障原因是电压互感器末端N端子与开口三角绕组(二次零序电压回路)之间绝缘击穿,电压互感器一次侧产生的放电电流在开口三角绕组中流通,从而引起二次零序电压异常波动.最后,针对本起事件所暴露出的问题,提出关于二次设备日常巡视工作的思考及建议.     

步进电机S曲线精确控制的研究与验证

针对生产中对步进电机运行时间和距离有精确要求的常见工况,设计一套步进电机S曲线控制算法,根据不同的运行要求灵活设定运动过程,设定较少参数即能规划整个运动路径,达到理想的运动效果。设计新型余弦S曲线,搭建MATLAB/Simulink仿真控制模型和硬件测试系统进行仿真和试验验证。结果显示电机实际加减速过程运行平滑,起步稳定振动小,设定参数下可以精确运行,与直接起停相比,运行效果有很大改善。新型余弦S曲线已在全自动号码机项目中得到实际应用。     

利伐沙班的合成工艺改进及其对映异构体杂质的制备

改进了利伐沙班(1)的合成工艺.以4-(4-氨基苯基)-3-吗啉酮(2)为起始原料、与R-环氧氯丙烷(7)加成,再与N,N'-羰基二咪唑环合、与邻苯二甲酰亚胺钾(8)取代,然后在水合肼中水解,最后与5-氯噻吩-2-甲酰氯(9)经酰化反应制得利伐沙班成品,总收率达46.1％,产品纯度大于99.8％,最大单杂小于0.1％.为了控制1的质量,建立1原料药的质量标准,根据改进的工艺合成路线,将产品的e.e值提高到99％以上,制备了对映异构体杂质(有关物质A),并经MS和NMR确认结构.     

Choline Acetyltransferase Induces the Functional Regeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice

Salivary gland dysfunction induces salivary flow reduction and a dry mouth, and commonly involves oral dysfunction, tooth structure deterioration, and infection through reduced salivation. This study aimed to investigate the impact of aging on the salivary gland by a metabolomics approach in an extensive aging mouse model, SAMP1/Klotho -/- mice. We found that the salivary secretion of SAMP1/Klotho -/- mice was dramatically decreased compared with that of SAMP1/Klotho WT (+/+) mice. Metabolomics profiling analysis showed that the level of acetylcholine was significantly decreased in SAMP1/Klotho -/- mice, although the corresponding levels of acetylcholine precursors, acetyl-CoA and choline, increased. Interestingly, the mRNA and protein expression of choline acetyltransferase (ChAT), which is responsible for catalyzing acetylcholine synthesis, was significantly decreased in SAMP1/Klotho -/- mice. The overexpression of ChAT induced the expression of salivary gland functional markers (α–amylase, ZO-1, and Aqua5) in primary cultured salivary gland cells from SAMP1/Klotho +/+ and -/- mice. In an in vivo study, adeno-associated virus (AAV)-ChAT transduction significantly increased saliva secretion compared with the control in SAMP1/Klotho -/- mice. These results suggest that the dysfunction in acetylcholine biosynthesis induced by ChAT reduction may cause impaired salivary gland function     

Utilizing an Animal Model to Identify Brain Neurodegeneration-Related Biomarkers in Aging

Glycine N-methyltransferase (GNMT) regulates S-adenosylmethionine (SAMe), a methyl donor in methylation. Over-expressed SAMe may cause neurogenic capacity reduction and memory impairment. GNMT knockout mice (GNMT-KO) was applied as an experimental model to evaluate its effect on neurons. In this study, proteins from brain tissues were studied using proteomic approaches, Haemotoxylin and Eosin staining, immunohistochemistry, Western blotting, and ingenuity pathway analysis. The expression of Receptor-interacting protein 1(RIPK1) and Caspase 3 were up-regulated and activity-dependent neuroprotective protein (ADNP) was down-regulated in GNMT-KO mice regardless of the age. Besides, proteins related to neuropathology, such as excitatory amino acid transporter 2, calcium/calmodulin-dependent protein kinase type II subunit alpha, and Cu-Zn superoxide dismutase were found only in the group of aged wild-type mice; 4-aminobutyrate amino transferase, limbic system-associated membrane protein, sodium- and chloride-dependent GABA transporter 3 and ProSAAS were found only in the group of young GNMT-KO mice and are related to function of neurons; serum albumin and Rho GDP dissociation inhibitor 1 were found only in the group of aged GNMT-KO mice and are connected to neurodegenerative disorders. With proteomic analyses, a pathway involving Gonadotropin-releasing hormone (GnRH) signal was found to be associated with aging. The GnRH pathway could provide additional information on the mechanism of aging and non-aging related neurodegeneration, and these protein markers may be served in developing future therapeutic treatments to ameliorate aging and prevent diseases.     

基于主动学习Kriging模型的地下管线抗震可靠度分析

为提升地下承插式接口铸铁管线抗震可靠度的计算效率,提出基于主动学习Kriging代理模型的Monte Carlo模拟方法(AK-MCS)进行地下管线抗震可靠度计算。采用梁单元模拟管线结构,均布弹簧反映管土相互作用,接口弹簧模拟邻接管道约束作用,建立了地下管线地震响应分析模型;考虑管线接口允许位移、管线埋深、土体容重和内摩擦角等模型参数随机性的影响,以管线接口位移量为安全准则,采用主动学习Kriging模型方法建立管线接口位移响应与随机变量参数关系的代理模型,从而获得管线接口安全状态。算例结果表明,AK-MCS法计算得到的管线失效概率与传统Monte Carlo模拟计算的结果相对误差在5%以内,且AK-MCS法计算时间约为传统Monte Carlo模拟计算时间的2%。因此在进行管线可靠度计算时,主动学习Kriging代理模型方法具有准确性与高效性。     

废旧纺织品在线NIR谱库的建立及检索识别应用

为了验证废旧纺织品在线近红外谱库的实用性,利用383个未参与建库的聚酯、棉、羊毛、锦纶、真丝、粘胶、腈纶、聚酯/毛、聚酯/锦纶、真丝棉、锦纶/氨纶、聚酯/棉12类织物样品对所建谱库进行在线检索识别.结果表明该方法识别正确率达98.7％,利用该谱库可对12种常见废旧纺织品进行在线识别和自动分选,为废旧纺织品回收分选提供一种新的方法和设备.     

分数阶滑模控制算法在四容水箱中的应用及仿真

针对四容水箱系统存在模型不确定性、动态性能缓慢、耦合严重等问题,设计分数阶滑模控制算法对水箱液位进行控制。对传统整数阶滑模面和趋近率加以改进,得到控制效果更为灵活的分数阶滑模面和趋近率。使用李雅普诺夫理论对分数阶型滑模控制器的渐进稳定条件、适用范围、特性进行理论分析,提出算法的设计方法。通过与分数阶PID控制器比较,仿真实验表明分数阶滑模控制器对给定液位的期望值具有良好的动态性能,有效的减少控制过程中的超调,对系统参数摄动具有良好的鲁棒性。     

公路隧道钢筋混凝土衬砌碳化耐久性区划

为了构建公路隧道衬砌碳化耐久性的定量设计方法,对比各碳化深度计算模型与实测数据,选定衬砌碳化的最优模型;根据实测数据分析隧道环境温湿度与洞外大气关系,基于全国气象监测站的温湿度数据,建立公路隧道运营环境温湿度区划;考虑公路隧道CO₂的释放源项并参照实测数据,构建隧道运营环境CO₂体积分数的计算方法;以碳化劣化速率梯度相等为原则,对我国隧道碳化环境进行分区,结合分区推荐我国公路隧道衬砌碳化耐久性定量设计的具体方法. 研究发现：隧道环境湿度与大气湿度相当,隧道环境温度变化趋势与大气环境一致,两者均值接近. 公路隧道内部CO₂体积分数与CO体积分数呈线性关系. 云南、贵州区修建的隧道工程衬砌受环境影响较大,西藏、青海、内蒙古、黑龙江、吉林等地区的待建隧道在进行衬砌耐久性设计时可以忽略碳化影响,其余全国大面积区域隧道衬砌的碳化耐久性设计可以对应《混凝土结构耐久性设计标准》中环境作用等级中的“轻度”进行设计.     

基于纳米压痕技术的电子玻璃微观力学性能研究

为了研究不同电子玻璃的微观力学性能,采用先进的纳米压痕技术记录钠钙硅、无碱硼铝硅和碱铝硅等典型电子玻璃的载荷-位移曲线,利用Oliver-Pharr方法和经典的弹塑性变形理论,计算玻璃的硬度和弹性模量. 玻璃的硬度主要与结构的键合度相关,平均非桥氧数越高,外力作用下越容易致密化,硬度越小;弹性模量主要取决于质点间的化学键强度,化学键力越强,变形越小,弹性模量越大;九点法测得的弹性模量与硬度的变化趋势不完全相同,借助硬度-弹性模量-能量耗散之间的本征关系,评价玻璃样品的微观均匀性,其中无碱硼铝硅玻璃的恢复阻力大,局部能量耗散大,不容易引起整体破坏,力学性能最好;与浮法工艺相比,溢流下拉法制备样品的局部力学性能波动较小,微观均匀性较好.