Natural killer or T-lymphocyte cells: Which is the best immune therapeutic agent for cancer? An optimal control approach

Therapeutic vaccines are being developed as a promising new approach to treatment for cancer patients. There are still many unanswered questions about which kind of therapeutic vaccines are the best for the cancer treatments? In this paper we consider a mathematical model, in the form of a system of ordinary differential equations (ODE), this system is an example from a class of mathematical models for immunotherapy of the tumor that were derived from a biologically validated model by Lisette G. de Pillis. The problem how to schedule a variable amount of which vaccines to achieve a maximum reduction in the primary cancer volume is consider as an optimal control problem and it is shown that optimal control is quadratic with 0 denoting a trajectory corresponding to no treatment and 1 a trajectory with treatment at maximum dose along that all therapeutics are being exhausted. The ODE system dynamics characterized by locating equilibrium points and stability properties are determined by using appropriate Lyapunov functions. Especially we attend a parametric sensitivity analysis, which indicates the dependency of the optimal solution with respect to disturbances in model parameters.     

Cracks coalescence mechanism and cracks propagation paths in rock-like specimens containing pre-existing random cracks under compression

The mechanism of cracks propagation and cracks coalescence due to compressive loading of the brittle substances containing pre-existing cracks （flaws） was modeled experimentally using specially made rock-like specimens from Portland Pozzolana Cement （PPC）. The breakage process of the specimens was studied by inserting single and double flaws with different inclination angles at the center and applying uniaxial compressive stress at both ends of the specimen. The first crack was oriented at 50＆#176; from the horizontal direction and kept constant throughout the analysis while the orientation of the second crack was changed. It is experimentally observed that the wing cracks are produced at the first stage of loading and start their propagation toward the direction of uniaxial compressive loading. The secondary cracks may also be produced in form of quasi-coplanar and/or oblique cracks in a stable manner. The secondary cracks may eventually continue their propagation in the direction of maximum principle stress. These experimental works were also simulated numerically by a modified higher order displacement discontinuity method and the cracks propagation and cracks coalescence were studied based on Mode I and Mode II stress intensity factors （SIFs）. It is concluded that the wing cracks initiation stresses for the specimens change from 11.3 to 14.1 MPain the case of numerical simulations and from 7.3 to 13.8 MPa in the case of experimental works. It is observed that cracks coalescence stresses change from 21.8 to 25.3 MPa and from 19.5 to 21.8 MPa in the numerical and experimental analyses, respectively. Comparing some of the numerical and experimental results with those recently cited in the literature validates the results obtained by the proposed study. Finally, a numerical simulation was accomplished to study the effect of confining pressure on the crack propagation process, showing that the SIFs increase and the crack initiation angles change in this case.     

A bio-inspired gelatin-based pH- and thermal-sensitive magnetic hydrogel for in vitro chemo/hyperthermia treatment of breast cancer cells

Gelatin (Gel)-based pH- and thermal-responsive magnetic hydrogels (MH-1 and MH-2) were designed and developed as novel drug delivery systems (DDSs) for cancer chemo/hyperthermia therapy. For this goal, Gel was functionalized with methacrylic anhydride (GelMA), and then copolymerized with (2-dimethylaminoethyl) methacrylate (DMAEMA) monomer in the presence of methacrylate-end capped magnetic nanoparticles (MNPs) as well as triethylene glycol dimethacrylate (TEGDMA; as crosslinker). Afterward, a thiol-end capped poly(N-isopropylacrylamide) (PNIPAAm-SH) was synthesized through an atom transfer radical polymerization technique, and then attached onto the hydrogel through “thiol-ene” click grafting. The preliminary performances of developed MHs for chemo/hyperthermia therapy of human breast cancer was investigated through the loading of doxorubicin hydrochloride (Dox) as an anticancer agent followed by cytotoxicity measurement of drug-loaded DDSs using MTT assay by both chemo- and chemo/hyperthermia-therapies. Owing to porous morphologies of the fabricated magnetic hydrogels according to scanning electron microscopy images and strong physicochemical interactions (e.g., hydrogen bonding) the drug loading capacities of the MH-1 and MH-2 were obtained as 72 ± 1.4 and 77 ± 1.8, respectively. The DDSs exhibited acceptable pH- and thermal-triggered drug release behaviors. The MTT assay results revealed that the combination of hyperthermia therapy and chemotherapy has synergic effect on the anticancer activities of the developed DDSs.     

Adaptive Network-Based Fuzzy Inference Systems Coupled with Genetic Algorithms for Predicting Soil Permeability Coefficient

This paper extends hybrid-type optimization models of genetic algorithm adaptive network-based fuzzy inference system (GA-ANFIS) for predicting the soil permeability coefficient (SPC) of different types of soil. In these models, GA optimizes parameters of a subtractive clustering technique that controls the structure of the ANFIS model’s fuzzy rule base. Simultaneously, a hybrid leaning algorithm is employed in the ANFIS, as a trained fuzzy inference system (FIS), which optimally determines the parameter sets of the examined FISs in ANFIS. Using an updated large database of SPCs consisting of 338 fine-grained, 178 mixed and 94 granular soil samples, GA-ANFIS framework constructs different models of predicting the permeability coefficient of respectively fine-grained, mixed and granular soils. A fuzzy C-mean technique has been used to cluster the entire data samples of each type of soil and divide them uniformly into training and testing data sets. Different prediction models of SPC have been trained and tested for each of the three soil types, and the appropriate models have been selected. The selected models have been compared with ANN and modified-by-GA empirical prediction models. Results show that the constructed GA-ANFIS models outperform the other models in terms of the prediction accuracy and the generalization capability.     

Textual image compression at low bit rates based on region-of-interest coding

In this paper, we deal with those applications of textual image compression where high compression ratio and maintaining or improving the visual quality and readability of the compressed images are of main concern. In textual images, most of the information exists in the edge regions; therefore, the compression problem can be studied in the framework of region-of-interest (ROI) coding. In this paper, the Set Partitioning in Hierarchical Trees (SPIHT) coder is used in the framework of ROI coding along with some image enhancement techniques in order to remove the leakage effect which occurs in the wavelet-based low-bit-rate compression. We evaluated the compression performance of the proposed method with respect to some qualitative and quantitative measures. The qualitative measures include the averaged mean opinion scores (MOS) curve along with demonstrating some outputs in different conditions. The quantitative measures include two proposed modified PSNR measures and the conventional one. Comparing the results of the proposed method with those of three conventional approaches, DjVu, JPEG2000, and SPIHT coding, showed that the proposed compression method considerably outperformed the others especially from the qualitative aspect. The proposed method improved the MOS by 20 and 30 %, in average, for high- and low-contrast textual images, respectively. In terms of the modified and conventional PSNR measures, the proposed method outperformed DjVu and JPEG2000 up to 0.4 dB for high-contrast textual images at low bit rates. In addition, compressing the high contrast images using the proposed ROI technique, compared to without using this technique, improved the average textual PSNR measure up to 0.5 dB, at low bit rates.     

Solving the Problem of Forbidden States in Discrete Event Systems: A Novel Systematic Method for Reducing the Number of Control Places

This paper deals with the problem of forbidden states in Discrete Event Systems modelled by non‐safe Petri Nets. To avoid these states, some Generalized Mutual Exclusion Constraints can be assigned to them. These constraints limit the weight sum of tokens in some places and can be enforced on the system using control places. When the number of these constraints is large, a large number of control places should be added to the system. In this paper, a method is presented to assign the small number of constraints to forbidden states using some states which cover the forbidden states. So, a small number of control places are added to the system leading to obtaining a maximally permissive controller.     

An automatic subdigraph renovation plan for failure recovery of composite semantic Web services

A Web service-based system never fulfills a user＇s goal unless a failure recovery approach exists. It is inevitable that several Web services may either perish or fail before or during transactions. The completion of a composite process relies on the smooth execution of all constituent Web services. A mediator acts as an intermediary between providers and consumers to monitor the execution of these services. If a service fails, the mediator has to recover the whole composite process or else jeopardize achieving the intended goals. The atomic replacement of a perished Web service usually does not apply because the process of locating a matched Web service is unreliable. Even the system cannot depend on the replacement of the dead service with a com- posite service. In this paper, we propose an automatic renova- tion plan for failure recovery of composite semantic services based on an approach of subdigraph replacement. A replacement subdigraph is posed in lieu of an original subdigraph, which includes the failed service. The replacement is done in two separate phases, ofltine and online, to make the recovery faster. The ofitine phase foresees all possible subdigraphs, pre-calculates them, and ranks several possible replacements. The online phase compensates the unwanted effects and executes the replacement subdigraph in lieu of the original subdigraph. We have evaluated our approach during an experiment and have found that we could recover more than half of the simulated failures. These achievements show a significant improvement compared to current approaches     

Spectral Measurement of the Film-Substrate Index Difference in Proton-Exchanged LiNbO(3) Waveguides

We report the spectral characterization of proton-exchanged lithium niobate (PE:LiNbO(3)) waveguides in terms of the variation of the refractive-index difference between the waveguiding layer and the substrate. The dispersion of the extraordinary refractive-index increase (deltan(e)) is measured from 405 to 1319 nm with several light sources. Two types of proton-exchanged waveguide, prepared under different conditions, are studied. These measurements should be of use in the optimization of PE:LiNbO(3) waveguides for nonlinear optical applications, particularly in second-harmonic generation in the blue-green wavelength region.