In medical information system, there are a lot of features and the relationship among elements is solid. In this way, feature selection of medical datasets gets awesome worry as of late. In this article, tolerance rough set firefly-based quick reduct, is developed and connected to issue of differential finding of diseases. The hybrid intelligent framework intends to exploit the advantages of the fundamental models and, in the meantime, direct their restrictions. Feature selection is procedure for distinguishing ideal feature subset of the original features. A definitive point of feature selection is to build the precision, computational proficiency and adaptability of expectation strategy in machine learning, design acknowledgment and information mining applications. Along these lines, the learning framework gets a brief structure without lessening the prescient precision by utilizing just the chose remarkable features. In this research, a hybridization of two procedures, tolerance rough set and as of late created meta-heuristic enhancement calculation, the firefly algorithm is utilized to choose the conspicuous features of medicinal information to have the capacity to characterize and analyze real sicknesses. The exploratory results exhibited that the proficiency of the proposed system outflanks the current supervised feature selection techniques.
Biofilms containing Candida albicans are responsible for a wide variety of clinical infections. The protective effects of the biofilm matrix, the low metabolic activity of microorganisms within a biofilm and their high mutation rate, significantly enhance the resistance of biofilms to conventional antimicrobial treatments. Peptoids are peptide‐mimics that share many features of host defence antimicrobial peptides but have increased resistance to proteases and therefore have better stability in vivo. The activity of a library of peptoids was tested against monospecies and polymicrobial bacterial/fungal biofilms. Selected peptoids showed significant bactericidal and fungicidal activity against the polymicrobial biofilms. This coupled with low cytotoxicity suggests that peptoids could offer a new option for the treatment of clinically relevant polymicrobial infections. 相似文献
Automatic trip hammers have advantages for standard penetration test (SPT) of consistent drop height and low friction loss during hammer fall. These advantages, however, generate high energy transfer ratios (ER), typically about 90%. This efficiency causes lower sensitivity and higher energy correction coefficients, CE. To reduce ER and CE and to increase the sensitivity of SPT conducted at the Wildlife Liquefaction Array (WLA) and the Garner Valley Downhole Array, instrumented Network for Earthquake Engineering Simulation sites, a 127?mm (5.00?in.) long sleeve was placed in the hammer mechanism to reduce the drop height from 762?mm (30?in.) to 635?mm (25in.). To calibrate the energy for these drop heights, measurements were made for a series of SPT tests in Borehole X2 at WLA on November 21, 2003. For these SPT, sleeves were inserted with lengths of 50?mm (2?in.), 127?mm (5?in.) 177?mm (7?in.), and no sleeve. Resulting drop heights were 762?mm (30?in.), 711?mm (28?in.), 635?mm (25?in.), and 584?mm (23?in.). Results indicate that: (1) ER increases with rod length as expected; (2) corrections for rod length, CR, increased with rod length in accordance with CR published in 2001 by Youd et al.; and (3) for lengths greater than 6?m, ER increased approximately linearly with drop height. Average ER30 [ER based on a 762?mm (30?in.) drop height] were 43% for a 584?mm (23?in.) drop, 60% for a 635?mm (25?in.) drop, 84% for 711?mm (28?in.) drop, and 89% for a 762?mm (30?in.) drop. 相似文献
Confidential industrial trials showed that higher purity crystals were produced in an oscillatory baffled crystallizer (OBC) compared to a stirred tank crystallizer (STC) when operating at similar conditions. This trend is verified in this work using urea as the test compound that is different from that was employed in industrial tests. We have observed that a higher supersaturation level at nucleation coupled with a lower nucleation temperature was measured in the STC at all investigated conditions compared to that in the OBC. This led to a higher nucleation rate in the STC, consequently producing smaller crystals. Crystal size distributions and imaging analyses suggest that these smaller crystals were more likely to form agglomerates in the STC, trapping either mother liquor or impurity or both and leading to the lower purity observed when compared to that in the OBC. 相似文献
We demonstrate vertically aligned epitaxial GaAs nanowires of excellent crystallographic quality and optimal shape, grown by Au nanoparticle-catalyzed metalorganic chemical vapor deposition. This is achieved by a two-temperature growth procedure, consisting of a brief initial high-temperature growth step followed by prolonged growth at a lower temperature. The initial high-temperature step is essential for obtaining straight, vertically aligned epitaxial nanowires on the (111)B GaAs substrate. The lower temperature employed for subsequent growth imparts superior nanowire morphology and crystallographic quality by minimizing radial growth and eliminating twinning defects. Photoluminescence measurements confirm the excellent optical quality of these two-temperature grown nanowires. Two mechanisms are proposed to explain the success of this two-temperature growth process, one involving Au nanoparticle-GaAs interface conditions and the other involving melting-solidification temperature hysteresis of the Au-Ga nanoparticle alloy. 相似文献
It was recently shown that ultrashort pulse infrared (IR) lasers, operating at the wavelength of the OH vibration stretching band of water, are highly efficient for sampling and homogenizing biological tissue. In this study we utilized a tunable nanosecond infrared laser (NIRL) for tissue sampling and homogenization with subsequent liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis for mass spectrometric proteomics. For the first time, laser sampling was performed with murine spleen and colon tissue. An ablation volume of 1.1 × 1.1 × 0.4 mm³ (approximately 0.5 µL) was determined with optical coherence tomography (OCT). The results of bottom-up proteomics revealed proteins with significant abundance differences for both tissue types, which are in accordance with the corresponding data of the Human Protein Atlas. The results demonstrate that tissue sampling and homogenization of small tissue volumes less than 1 µL for subsequent mass spectrometric proteomics is feasible with a NIRL. 相似文献
The effects of supplementing cows' diets with protein and energy on milk composition and the composition and yield of Cheddar cheese were investigated. This research addresses the problems of seasonal reduction in the capacity of cheese curds to expel moisture as observed in parts of south-eastern Australia. Milk was collected from cows offered a basal diet of silage and hay supplemented with different sources and levels of dietary protein and energy. The protein supplements were sunflower, canola, cottonseed meal and lupin, and the energy supplements were maize grain, oats, wheat and barely. This milk was used to manufacture Cheddar cheese on a pilot scale. Cheese moisture content was dependent on the source and level of dietary protein and energy. Milk from cows offered the lupin protein supplements and wheat energy supplements consistently produced cheese with a lower moisture content and moisture in fat-free matter. Milk from these supplemented diets had increased casein concentrations and higher proportions of alpha S2-casein than milk from the poor quality control diet. Cheese yield was directly related to the total casein concentration of milk, but was not influenced by differences in casein composition. Supplementing the cows' diets increased the inorganic P, Mg and Ca concentrations in milk. A low inorganic P concentration in milk from cows offered the control diet was caused by a low intake of dietary P. These findings showed that changes in the mineral and casein composition of milk, associated with diet, could influence the composition of Cheddar cheese. 相似文献