Release of Cu2+ from a copper-filled TiO2 coating in a rabbit model for total knee arthroplasty

The aim of this study was the investigation of a copper-filled TiO₂ coating, that in vitro showed good antibacterial properties combined with good tissue tolerance in an animal model. To better understand the antibacterial mechanism of the bioactive coating the release of copper (Cu) ions over time was monitored to be able to detect possible threats as well as possible fields of application. 30 New Zealand White rabbits were divided into two groups with 15 animals per group. In group 1 (control group) Ti6Al4 V bolts were implanted into the distal femur, in group 2 the Ti6Al4 V bolts were coated with four TiO₂-coatings with integrated Cu²⁺-ions (4 × Cu–TiO₂). Blood tests were performed weekly until the animals were sacrificed 4 weeks postoperative. The maximum peak of Cu and ceruloplasmin concentration could be seen in both groups one week postoperative, whereas the Cu values in group II were significantly higher. The Cu concentration in both groups approximated the initial basic values 4 weeks postoperative. The 4 × Cu–TiO₂ coating tested in our rabbit model for total knee arthroplasty is an active coating that releases potentially antibacterial Cu²⁺ for 4 weeks with a peak 1 week postoperative. The bioactive coating could be a promising approach for a use in the field of implant related infection, orthopaedic revision and tumor surgery in the future.     

Quantitative Imaging of the Magnetic Configuration of Modulated Nanostructures by Electron Holography

By means of off‐axis electron holography the local distribution of the magnetic induction within and around a poly‐crystalline Permalloy (Ni₈₁Fe₁₉) thin film is studied. In addition the stray field above the sample is measured by magnetic force microscopy on a larger area. The film is deposited on a periodically nanostructured (rippled) Si substrate, which was formed by Xe⁺ ion beam erosion. This introduces the periodical ripple shape to the Permalloy film. The created ripple morphology is expected to modify the magnetization distribution within the Permalloy and to induce dipolar stray fields. These stray fields play an important role in spinwave dynamics of periodic nanostructures like magnonic crystals. Micromagnetic simulations estimate those stray fields in the order of only 10 mT. Consequently, their experimental determination at nanometer spatial resolution is highly demanding and requires advanced acquisition and reconstruction techniques such as electron holography. The reconstructed magnetic phase images show the magnetized thin film, in which the magnetization direction follows mainly the given morphology. Furthermore, a closer look to the Permalloy/carbon interface reveals stray fields at the detection limit of the method in the order of 10 mT, which is in qualitative agreement with the micromagnetic simulations.     

African regional innovation systems: bibliometric analysis of research collaboration patterns 2005–2009

Understanding the nature and dynamics of Africa’s collaborative research networks is critical for building and integrating the African innovation system. This paper investigates the collaborative structure of the African research systems, with focus on regions and integration. Drawing on a bibliometric analysis of co-authorship of African research publications in 2005–2009, we propose an empirically derived grouping of African research community into three distinct research regions: Southern–Eastern, Western, and Northern. The three regions are established and defined in terms of active co-authorship clusters within Africa, as well as through co-authorship links with non-African countries and regions. We examine co-authorship links both at the national and city levels in order to provide a robust and nuanced empirical basis for the three African research regions. The collaboration patterns uncovered cast light on the emerging innovation systems in Africa by pointing out the differing national, regional, and global roles of countries and cities within collaborative research networks. Lack of research capabilities is the primary factor arresting the development of African innovation systems, but our analysis also suggests that Africa’s internal research collaboration suffers from structural weaknesses and uneven integration. We also identify that South Africa, and some emerging new research hubs, hold critical networking function for linking African researchers.     

Personality subtypes of young moped drivers, their relationship to risk-taking behavior and involvement in road crashes in an Austrian sample

Objective

This study aimed to identify subtypes of young moped drivers and analyze how these subtypes are involved in risk preferences and road crashes.

Design

A group of Austrian teenage moped drivers (213, 28% girls) completed an online questionnaire about moped usage, injuries, driving style, inattention, impulsivity, and personality according to the Five-Factor Model of Personality and Cloninger's model of personality.

Results

A cluster analysis yielded four types of moped drivers. One type was characterized by a high level of neuroticism, the second type was characterized by a risky personality and a risky driving style, the third type had a more cautious driving style, and the fourth type was characterized by a risky personality and high levels on inattention and impulsivity.

Conclusions

Our conclusions suggest that young moped drivers should not be perceived as a homogenous group, according to measures of injury prevention and intervention.     

An information-theoretic approach to combining object models

This paper introduces a new method for combining different object models. By determining a configuration of the models, which maximizes their mutual information, the proposed method creates a unified hypothesis from multiple object models on the fly without prior training. To validate the effectiveness of the proposed method, experiments are conducted in which human faces are detected and localized in images by combining different face models.     

On Discriminative Bayesian Network Classifiers and Logistic Regression

Discriminative learning of the parameters in the naive Bayes model is known to be equivalent to a logistic regression problem. Here we show that the same fact holds for much more general Bayesian network models, as long as the corresponding network structure satisfies a certain graph-theoretic property. The property holds for naive Bayes but also for more complex structures such as tree-augmented naive Bayes (TAN) as well as for mixed diagnostic-discriminative structures. Our results imply that for networks satisfying our property, the conditional likelihood cannot have local maxima so that the global maximum can be found by simple local optimization methods. We also show that if this property does not hold, then in general the conditional likelihood can have local, non-global maxima. We illustrate our theoretical results by empirical experiments with local optimization in a conditional naive Bayes model. Furthermore, we provide a heuristic strategy for pruning the number of parameters and relevant features in such models. For many data sets, we obtain good results with heavily pruned submodels containing many fewer parameters than the original naive Bayes model.Editors: Pedro Larrañaga, Jose A. Lozano, Jose M. Peña and Iñaki Inza     

Halogen bonding based recognition processes: a world parallel to hydrogen bonding

Halogen bonding is the noncovalent interaction between halogen atoms (Lewis acids) and neutral or anionic Lewis bases. The main features of the interaction are given, and the close similarity with the hydrogen bonding will become apparent. Some heuristic principles are presented to develop a rational crystal engineering based on halogen bonding. The focus is on halogen-bonded supramolecular architectures given by halocarbons. The potential of the interaction is shown by useful applications in the field of synthetic chemistry, material science, and bioorganic chemistry.     

Process control of lightly salted wild and farmed Atlantic cod (Gadus morhua) by brine injection, brining, and freezing--a low field NMR study

The aim of this study was to use low-field nuclear magnetic resonance (NMR) and traditional chemical methods to investigate the physical and chemical differences in wild and farmed cod processed pre- and postrigor, and how these properties were affected by brine injection, brining, and freezing. In prerigor processed farmed or wild cod, brine injections followed by brining for 2 d, with brine concentrations up to 5.5% and 4%, respectively, were not sufficient to reach a muscle salt concentration of 2% as aimed for, while wild cod processed postrigor had sufficient salt uptake after the same processing. Low-field NMR gave valuable information about the differences in the muscle structure between wild and farmed cod as well as the state of the water in the muscle during brine injection, brining, and during rigor tension. Low-field NMR is, therefore, a valuable tool that can be used to optimize the salting and storing processes of lightly salted cod products from both wild and farmed cod. For farmed cod to be used in the production of lightly salted products further research is needed. Practical Application: Optimal processing of lightly salted cod products is important to the fish industry, due to an increasing market for this product in southern Europe. Farmed cod, which is seen as a potential steady raw material source for this production, differs considerably from its wild counterparts by having other chemical and physical muscle properties, such as lower water content and lower pH. With the processing procedures used today the farmed cod can, therefore, only be used in some of the products, where wild cod is currently used as raw material. It is, therefore, important that the processing of these products is optimized with regard to these differences in the raw material. This study gives a valuable contribution to further studies about optimal combinations of brine injections, brining, and freezing of pre- and postrigor processed farmed compared to wild cod.