Multifunctional nanoparticles such as magneto‐plasmonic nanohybrids are rising theranostic agents. However, little is yet known of their fate within the cellular environment. In order to reach an understanding of their biotransformations, reliable metrics for tracking and quantification of such materials properties during their intracellular journey are needed. In this study, their long‐term (one month) intracellular fate is followed within stem‐cell spheroids used as tissue replicas. A set of magnetic (magnetization) and thermal (magnetic hyperthermia, photothermia) metrics is implemented to provide reliable insightsinto the intracellular status. It shows that biodegradation is modulated by the morphology and thickness of the gold shell. First a massive dissolution of the iron oxide core (nanoflower‐like) is observed, starting with dissociation of the multigrain structure. Second, it is demonstrated that an uninterrupted gold shell can preserve the magnetic core and properties (particularly magnetic hyperthermia). In addition to the magnetic and thermal metrics, intracellular high‐resolution chemical nanocartography evidences the gradual degradation of the magnetic cores. It also shows different transformation scenarios, from the release of small gold seeds when the magnetic core is dissolved (interesting for long‐term elimination) to the protection of the magnetic core (interesting for long‐term therapeutic applicability). 相似文献
The smart grid control applications necessitate real-time communication systems with time efficiency for real-time monitoring, measurement, and control. Time-efficient communication systems should have the ability to function in severe propagation conditions in smart grid applications. The data/packet communications need to be maintained by synchronized timing and reliability through equally considering the signal deterioration occurrences, which are propagation delay, phase errors and channel conditions. Phase synchronization plays a vital part in the digital smart grid to get precise and real-time control measurement information. IEEE C37.118 and IEC 61850 had implemented for the synchronization communication to measure as well as control the smart grid applications. Both IEEE C37.118 and IEC 61850 experienced a huge propagation and packet delays due to synchronization precision issues. Because of these delays and errors, measurement and monitoring of the smart grid application in real-time is not accurate. Therefore, it has been investigated that the time synchronization in real-time is a critical challenge in smart grid applications, and for this issue, other errors raised consequently. The existing communication systems are designed with the phasor measurement unit (PMU) along with communication protocol IEEE C37.118 and uses the GPS timestamps as the reference clock stamps. The absence of GPS increases the clock offsets, which surely can hamper the synchronization process and the full control measurement system that can be imprecise. Therefore, to reduce this clock offsets, a new algorithm is needed which may consider any alternative reference timestamps rather than GPS. The revolutionary Artificial Intelligence (AI) enables the industrial revolution to provide a significant performance to engineering solutions. Therefore, this article proposed the AI-based Synchronization scheme to mitigate smart grid timing issues. The backpropagation neural network is applied as the AI method that employs the timing estimations and error corrections for the precise performances. The novel AIFS scheme is considered the radio communication functionalities in order to connect the external timing server. The performance of the proposed AIFS scheme is evaluated using a MATLAB-based simulation approach. Simulation results show that the proposed scheme performs better than the existing system.
This work describes a class of complex combining three dithienylethene units and a lanthanide ion used as an optical system displaying a double encryption method: i) a colorful code, drawn and erased under UV and visible irradiations respectively, due to coloration and discoloration of the photochromic entities, and ii) a concomitant gradual disappearance and progressive restoration of the associated lanthanide ion luminescence triggered with the same stimuli. The innovation of the system stems from the emission color tunability, i.e., with either a lanthanide ion emitting only in the visible range (Eu3+) or with another lanthanide ion emitting only in the near infrared (NIR) range (Yb3+), therefore observable, or not, to the naked eye. This system is the very first one to achieve efficient repeatable modulation of pure NIR luminescence on photochemical command. Furthermore, it is proven to be highly efficient when embedded in a PDMS polymer opening real opportunities for practical applications as anti‐counterfeiting. 相似文献
This paper proposes a novel method for camera calibration using images of a mirror symmetric object. Assuming unit aspect ratio and zero skew, we show that interimage homographies can be expressed as a function of only the principal point. By minimizing symmetric transfer errors, we thus obtain an accurate solution for the camera parameters. We also extend our approach to a calibration technique using images of a 1-D object with a fixed pivoting point. Unlike existing methods that rely on orthogonality or pole-polar relationship, our approach utilizes new inter-image constraints and does not require knowledge of the 3-D coordinates of feature points. To demonstrate the effectiveness of the approach, we present results for both synthetic and real images. 相似文献
Patient Physiological Parameters (PPPs) seem to be the most extensively accessed and utilized Personal Health Information (PHI) in hospitals, and their utilization by the various medical entities for treatment and diagnosis creates a real threat to patient privacy. This study aims to investigate whether PPPs access in a hospital environment violates patient privacy. If so, to what extent can we manage patient privacy while accessing PPPs in this environment? We investigated this question by analyzing questionnaire-based data from two Asian countries: Group A (China) and Group B (Pakistan). For data collection, we targeted those medical entities which were directly dealing with PPPs in their routine tasks. Results suggest that patient type directly influences the collection of PPPs: Group A (one-time?=?1.9, follow-up?=?1.06) and Group B (one-time?=?2.0 and follow-up?=?1.9). Both groups agreed that patients have the right to control their own PPPs. In both, doctors are the most trusted entity: for Group A, the Pearson Chi-Square with one degree of freedom is 1.414, p?=?0.234, whereas for Group B, the Pearson Chi-Square with three degrees of freedom is 4.511, p?=?0.11. Most of the Group A entities (92%) are familiar with unauthorized access of PPPs, while in Group B the level was only 35%. In Group B, only 35% of entities stated the purpose, specification and use limitations of PPPs. Doctors in both groups showed a high utilization of PPPs read authorization rights. This empirical evidence about PPPs usage in both countries will benefit health technology and improve policy on patient privacy. 相似文献
Routing protocols are the binding force in mobile ad hoc network (MANETs) since they facilitate communication beyond the wireless
transmission range of the nodes. However, the infrastructure-less, pervasive, and distributed nature of MANETs renders them
vulnerable to security threats. In this paper, we propose a novel cluster-based trust-aware routing protocol (CBTRP) for MANETs
to protect forwarded packets from intermediary malicious nodes. The proposed protocol organizes the network into one-hop disjoint
clusters then elects the most qualified and trustworthy nodes to play the role of cluster-heads that are responsible for handling
all the routing activities. The proposed CBTRP continuously ensures the trustworthiness of cluster-heads by replacing them
as soon as they become malicious and can dynamically update the packet path to avoid malicious routes. We have implemented
and simulated the proposed protocol then evaluated its performance compared to the clustered based routing protocol (CBRP)
as well as the 2ACK approach. Comparisons and analysis have shown the effectiveness of our proposed scheme. 相似文献
A two-dimensional cross-section finite difference model is presented to simulate density dependent leachate migration in leaky aquifers. Unlike existing models, a new approach is adopted to couple the groundwater-flow equation and the hydrodynamic dispersion equation with the elimination of the intermediate step of calculating velocities. The concept of the reference density is employed, permitting increased accuracy (over pressure-based models) in the representation of the transport process. The model is then used to study the effect of several hydraulic and transport parameters on the flow pattern and plume migration which are found to be very sensitive to most of these parameters. Equiconcentration and equipotential lines are overlapped to provide a better understanding of the coupling effect. 相似文献
Scientometrics - Recently, tremendous advances have been observed in information retrieval systems designed to search for relevant knowledge in scientific publications. Although these techniques... 相似文献