Protein Kinases and Parkinson’s Disease

Currently, the lack of new drug candidates for the treatment of major neurological disorders such as Parkinson’s disease has intensified the search for drugs that can be repurposed or repositioned for such treatment. Typically, the search focuses on drugs that have been approved and are used clinically for other indications. Kinase inhibitors represent a family of popular molecules for the treatment and prevention of various cancers, and have emerged as strong candidates for such repurposing because numerous serine/threonine and tyrosine kinases have been implicated in the pathobiology of Parkinson’s disease. This review focuses on various kinase-dependent pathways associated with the expression of Parkinson’s disease pathology, and evaluates how inhibitors of these pathways might play a major role as effective therapeutic molecules.     

Adsorption performance of mesoporous silicas towards a cationic dye. Influence of mesostructure on adsorption capacity

The dye adsorption performance of four mesoporous silicas with different structure and textural properties, MCM-41, MCM-48, SBA-15 and mesocellular silica foam (MCF), was studied and compared by using toluidine blue O (TBO) as dye model in aqueous solution. These materials were characterized by X-ray diffraction (XRD), small-angle X-ray scattering, nitrogen adsorption-desorption analyses, and transmission electron microscopy (TEM). The effect of some parameters such as adsorbent dosage, contact time, temperature, and pH on the TBO removal in aqueous solution was studied. Results showed that adsorption capacity raised when adsorbent dosage, contact time and pH solution were increased while an increase in temperature decreased the adsorption of TBO. Langmuir, Freundlich and Temkin isotherm models were employed to elucidate the adsorption mechanism while the adsorption rate data were analyzed according to the pseudo-first and second-order kinetic models. Results showed that adsorption of TBO onto MCM-48, SBA-15, and MCF fitted well the Freundlich isotherm model while the kinetic studies showed that adsorption process could be better described by the pseudo-second-order model for all mesoporous silicas. Finally, some solvents were evaluated to carried out dye desorption from the TBO-loaded mesoporous silicas founding that acetic acid was the most efficient.     

Generic entity resolution with negative rules

Entity resolution (ER) (also known as deduplication or merge-purge) is a process of identifying records that refer to the same real-world entity and merging them together. In practice, ER results may contain “inconsistencies,” either due to mistakes by the match and merge function writers or changes in the application semantics. To remove the inconsistencies, we introduce “negative rules” that disallow inconsistencies in the ER solution (ER-N). A consistent solution is then derived based on the guidance from a domain expert. The inconsistencies can be resolved in several ways, leading to accurate solutions. We formalize ER-N, treating the match, merge, and negative rules as black boxes, which permits expressive and extensible ER-N solutions. We identify important properties for the rules that, if satisfied, enable less costly ER-N. We develop and evaluate two algorithms that find an ER-N solution based on guidance from the domain expert: the GNR algorithm that does not assume the properties and the ENR algorithm that exploits the properties.     

Mutual exclusion in partitioned distributed systems

A network partition can break a distributed computing system into groups of isolated nodes. When this occurs, a mutual exclusion mechanism may be required to ensure that isolated groups do not concurrently perform conflicting operations. We study and formalize these mechanisms in three basic scenarios: where there is a single conflicting type of action; where there are two conflicting types, but operations of the same type do not conflict; and where there are two conflicting types, but operations of one type do not conflict among themselves. For each scenario, we present applications that require mutual exclusion (e.g., name servers, termination protocols, concurrency control). In each case, we also present mutual exclusion mechanisms that are more general and that may provide higher reliability than the voting mechanisms that have been proposed as solutions to this problem. Daniel Barbara is a graduate student in the Computer Science Department at Princeton University and expects to receive his Ph.D. Degree by July 1985. He obtained his BS in Electrical Engineering at the Universidad Metropolitana, Caracas, Venezuela in 1975. His research interests are Distributed Systems, Databases and Computer Networks. He is a member of IEEE and ACM. Hector Garcia-Molina is associate professor in the Department of Computer Science at Princeton University, Princeton, New Jersey. His research interests include distributed computing systems and database systems. He received a BS in electrical engineering from the Instituto Tecnologico de Monterrey. Mexico, in 1974. From Stanford University, Stanford, California, he received in 1975 a MS in electrical engineering and a PhD in computer science in 1979. Garcia-Molina is a member of the ACM and IEEE.     

Analyzing an inventory system with multiple reorder points and periodic replenishment

This paper investigates multiple reorder point, periodic replenishment systems similar to those utilized on board some U.S. naval vessels for Selected Item Management (SIM). This inventory system is of interest since it involves both regular and priority replenishment, three reorder points, and cyclical restocking of regular orders. A simulation model is developed to study the impact of demand distribution, cycle time, priority order leadtime, and the quantity of units ordered on the performance of the system. It is found that the frequency of service and days without shortages performance measures can be maximized by setting the reorder points at equal intervals between the zero level and the high level. Also, a power approximation model is presented that estimates the high level that will lead to a desired percent days without shortage percentage.     

Solution Phase Preparative Routes to Nitride Morphologies of Interest in Catalysis

This review assesses the track record and prospects of non-oxide sol–gel and solvothermal routes to nitride materials for use in catalysis. There is a strongly developing body of synthesis methods that yield highly porous materials, some with engineered pore structures, nanocrystalline materials with high surface areas and anisotropic nanocrystals that have their surface area tuned to a particular crystal face. Most of the existing catalytic work on such solution-derived nitrides has focussed on utilising base properties due to surface bound amide and imide groups in silicon (imido)nitride compositions, but there are opportunities to extend these methods to other interesting nitride compositions.     

A Parallel Implementation of Multiple Secret Image Sharing Based on Cellular Automata

Recently, a multisecret sharing scheme for secret color images among a set of users was proposed, which allows that each participant to share secret color images with the rest of participants in such way that all of them can recover all secret color images only if all participants pool their shares. In this work a parallel implementation of the cellular automata-based multisecret sharing scheme is proposed, in which the technology of CUDA （Compute Unified Device Architecture） is used in parallelization, taking advantage that each cell of cellular automata can be processed independently. The processing time of the proposed scheme is analyzed and it is proved that the proposed parallel algorithm using the CUDA structure is more than 12 times faster than the conventional sequential algorithm. This reduction of temporal complexity allows the practical use of the secret sharing scheme in many information security fields.     

Immobilized lipase reactors for modification of fats and oils—A review

This review focuses on the use of immobilized lipase technology to effect hydrolysis, ester synthesis, and interesterification reactions. The various immobilization procedures, reactor configurations, and process considerations are all reviewed and discussed.