Preparation of bao-pbo-nd2o3-tio2 powders by hydrothermal synthesis

Homogeneous and nano-sized BPNT [(Ba_1-xPb_x)Nd₂Ti₅O₁₄] powders were prepared under various hydrothermal conditions. Crystallinity and homogeneity of the synthetic powders were investigated. The microwave dielectric properties of the filters prepared with hydrothermal powders were compared with those of the filters prepared with conventional powders. The microwave dielectric properties of the filter prepared with the hydrothermal powders were also better than those of the filter manufactured with the conventional powders. The dielectric constant, quality constant and temperature coefficient of resonance frequency of hydrothermally prepared filter under optimum condition and measured at 3.5 GHz around were about 93, 6067 and 0 ppm/°C, respectively.     

Challenges of Raman Amplification

Raman amplifiers are often regarded as a typical example of technologies rapidly developed in the midst of turmoil created by the so-called wavelength division multiplexing (WDM) bubble. Indeed, Raman amplifiers turned out to be technically very attractive in all the aspects of capacity, reach, and bit rate. Even though Raman amplifiers are actually being deployed into systems in commercial service, the practical issues, such as cost, reliability and safety, are yet to be further discussed, particularly for the configuration of distributed amplification. After summarizing the advantages of Raman amplification and reviewing pump laser technologies, this paper will highlight ongoing efforts on practical issues, which include reliability and safety issues of fiber under high-power operations. Finally, it is concluded that by overcoming the above-mentioned practical issues, Raman amplification will stay as a key technology for future optical communications because of its compelling unique advantages.     

Recursive nonlinear observer design: beyond the uniform observability

We propose a recursive design scheme of a state observer for multiple-input-multiple-output, partly lower triangular nonlinear systems. The design begins from the subdynamics far from the output and propagates to the subdynamics close to the output, recalling the backstepping scheme for nonlinear control. The proposed class of systems is fairly general since it includes nonuniformly observable and/or detectable multioutput systems. Error convergence to zero is proved assuming boundedness of inputs a posteriori (i.e., after the design), which is preferable whereas most results in the literature assume the boundedness; a priori (i.e., before the design). A global observer is proposed with the global Lipschitz condition of the system, but without any restriction on the size of Lipschitz coefficient. The Lipschitz condition can be removed when a semiglobal observer is of interest.     

Development of a prototype customer-oriented virtual factory system

Current Computer integrated manufacturing/Enterprise Resource Planning (CIM/ERP) systems require harmony and communication between humans and facilities. A user’s preferences should also be considered in CIM/ERP systems. Virtual factory (VF), also known as virtual manufacturing (VM), systems can fulfill the requirements of current CIM/ERP systems. A VF system simulates virtual production in a virtual factory environment on the computer system which allows optimization prior to going into production. In this paper, we defined a VF system as a pre-analyzing system for designing, engineering and manufacturing a product in the enterprise system of the real world. The objective of this paper is to design a VF system and to develop a prototype system that the customer can participate in and be satisfied with. We selected a telephone as a sample product for the VF system. The VF system consists of four subsystems: virtual product ordering, design, manufacturing, and CIM/ERP interface. The prototype system aims to develop a virtual product ordering and design system.     

Col4a3-/- Mice on Balb/C Background Have Less Severe Cardiorespiratory Phenotype and SGLT2 Over-Expression Compared to 129x1/SvJ and C57Bl/6 Backgrounds

Alport syndrome (AS) is a hereditary renal disorder with no etiological therapy. In the preclinical Col4a3^-/- model of AS, disease progression and severity vary depending on mouse strain. The sodium-glucose cotransporter 2 (SGLT2) is emerging as an attractive therapeutic target in cardiac/renal pathologies, but its application to AS remains untested. This study investigates cardiorespiratory function and SGLT2 renal expression in Col4a3^-/- mice from three different genetic backgrounds, 129x1/SvJ, C57Bl/6 and Balb/C. male Col4a3^-/- 129x1/SvJ mice displayed alterations consistent with heart failure with preserved ejection fraction (HFpEF). Female, but not male, C57Bl/6 and Balb/C Col4a3^-/- mice exhibited mild changes in systolic and diastolic function of the heart by echocardiography. Male C57Bl/6 Col4a3^-/- mice presented systolic dysfunction by invasive hemodynamic analysis. All strains except Balb/C males demonstrated alterations in respiratory function. SGLT2 expression was significantly increased in AS compared to WT mice from all strains. However, cardiorespiratory abnormalities and SGLT2 over-expression were significantly less in AS Balb/C mice compared to the other two strains. Systolic blood pressure was significantly elevated only in mutant 129x1/SvJ mice. The results provide further evidence for strain-dependent cardiorespiratory and hypertensive phenotype variations in mouse AS models, corroborated by renal SGLT2 expression, and support ongoing initiatives to develop SGLT2 inhibitors for the treatment of AS.     

Single-Step Fast Tissue Clearing of Thick Mouse Brain Tissue for Multi-Dimensional High-Resolution Imaging

Recent advances in optical clearing techniques have dramatically improved deep tissue imaging by reducing the obscuring effects of light scattering and absorption. However, these optical clearing methods require specialized equipment or a lengthy undertaking with complex protocols that can lead to sample volume changes and distortion. In addition, the imaging of cleared tissues has limitations, such as fluorescence bleaching, harmful and foul-smelling solutions, and the difficulty of handling samples in high-viscosity refractive index (RI) matching solutions. To address the various limitations of thick tissue imaging, we developed an Aqueous high refractive Index matching and tissue Clearing solution for Imaging (termed AICI) with a one-step tissue clearing protocol that was easily made at a reasonable price in our own laboratory without any equipment. AICI can rapidly clear a 1 mm thick brain slice within 90 min with simultaneous RI matching, low viscosity, and a high refractive index (RI = 1.466), allowing the imaging of the sample without additional processing. We compared AICI with commercially available RI matching solutions, including optical clear agents (OCAs), for tissue clearing. The viscosity of AICI is closer to that of water compared with other RI matching solutions, and there was a less than 2.3% expansion in the tissue linear morphology during 24 h exposure to AICI. Moreover, AICI remained fluid over 30 days of air exposure, and the EGFP fluorescence signal was only reduced to ~65% after 10 days. AICI showed a limited clearing of brain tissue >3 mm thick. However, fine neuronal structures, such as dendritic spines and axonal boutons, could still be imaged in thick brain slices treated with AICI. Therefore, AICI is useful not only for the three-dimensional (3D) high-resolution identification of neuronal structures, but also for the examination of multiple structural imaging by neuronal distribution, projection, and gene expression in deep brain tissue. AICI is applicable beyond the imaging of fluorescent antibodies and dyes, and can clear a variety of tissue types, making it broadly useful to researchers for optical imaging applications.     

Verifying Global Minima for L 2 Minimization Problems in Multiple View Geometry

We consider the least-squares (L2) minimization problems in multiple view geometry for triangulation, homography, camera resectioning and structure-and-motion with known rotation, or known plane. Although optimal algorithms have been given for these problems under an L-infinity cost function, finding optimal least-squares solutions to these problems is difficult, since the cost functions are not convex, and in the worst case may have multiple minima. Iterative methods can be used to find a good solution, but this may be a local minimum. This paper provides a method for verifying whether a local-minimum solution is globally optimal, by providing a simple and rapid test involving the Hessian of the cost function. The basic idea is that by showing that the cost function is convex in a restricted but large enough neighbourhood, a sufficient condition for global optimality is obtained. The method is tested on numerous problem instances of real data sets. In the vast majority of cases we are able to verify that the solutions are optimal, in particular, for small to medium-scale problems.     

Three-dimensional Petersen-torus network: a fixed-degree network for massively parallel computers

A two-dimensional (2D) Petersen-torus network is a mesh-class fixed-degree network designed using a Petersen graph, which has a maximum of 10 nodes when the degree is 3 and the diameter is 2 in a (d,k)-graph problem. Here, I propose a new three-dimensional (3D) Petersen-torus network that extends the 2D Petersen-torus network without increasing the degree. The 3D Petersen-torus has the same number of nodes (N). The 3D Petersen-torus is better than the well-known 3D torus and 3D honeycomb mesh in terms of diameter and network cost. The 3D Petersen-torus network is better than the hypercube-like and star graph-like networks in terms of extendibility. Hence, the proposed network may serve as the foundation for realizing a high-performance multicomputer. In this paper, the optimal routing algorithm, Hamilton cycle, and several basic attributes are discussed. Furthermore, a comparison with a mesh-class fixed-degree 3D network is made for degree, diameter, and network cost.     

The interplay of conscious and automatic mechanisms in the context of routine use: An integrative and comparative study of contrasting mechanisms

Researchers have been closely studying how information technology services became a routine part of our lives. Studies have found that users who routinely use online services either consciously develop loyalty or automatically develop a habit. But many studies now mix the elements of conscious and automatic use despite the great differences in these phenomena. This study proposes a new theoretical framework of how the conscious and automatic mechanisms simultaneously, but differentially, regulate postadoption phenomena in the context of online information services. An empirical test confirms that these two mechanisms have highly discernible patterns that researchers and managers alike must heed.