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排序方式: 共有1293条查询结果,搜索用时 31 毫秒
31.
Armando Carravetta Giuseppe Del Giudice Oreste Fecarotta Helena M. Ramos 《Water Resources Management》2012,26(13):3947-3959
Pump operating as turbine (PAT) is an effective source of reducing the equipment cost in small hydropower plants. However, the manufacturers provide poor information on the PAT performance thus representing a limit for its wider diffusion. Additional implementation difficulties arise under variable operating conditions, characteristic of water distribution networks (WDNs). WDNs allow to obtain widespread and globally significant amount of produced energy by exploiting the head drop due to the network pressure control strategy for leak reductions. Thus a design procedure is proposed that couples a parallel hydraulic circuit with an overall plant efficiency criteria for the market pump selection within a WDN. The proposed design method allows to identify the performance curves of the PAT that maximizes the produced energy for an assigned flow and pressure-head distribution pattern. Finally, computational fluid dynamics (CFD) is shown as a suitable alternative for performance curve assessment covering the limited number of experimental data. 相似文献
32.
Previous research has shown loneliness as a threat for the quality of life of older people; therefore the goal of the intervention in a quasi-experimental study was to evaluate and discuss the self-reported level of loneliness of older people in Finland and Slovenia before and after a computer intervention. Intervention in a quasi-experimental study was conducted among 58 older participants at the baseline (M = 72.4 years) and 45 older participants at the follow-up research study (M = 72.9 years). Inferential statistics showed a significant difference in the reduction of loneliness between the countries, and a decreased level of loneliness of older people after completing the computer training course. Although older people experience many age-related problems which may reduce their interest in learning information and communication technology (ICT) skills, it is important that they are computer-proficient, because computer engagement can reduce the level of loneliness of older people and in this way has a positive effect on their quality of life. 相似文献
33.
Franko Debra L.; Striegel-Moore Ruth H.; Bean Judy; Tamer Robert; Kraemer Helena C.; Dohm Faith-Anne; Crawford Patricia B.; Schreiber George; Daniels Stephen R. 《Canadian Metallurgical Quarterly》2005,24(6):586
Depression in adolescent girls may result in negative consequences in young adulthood. The Center for Epidemiologic Studies Depression Scale (CES-D) was administered to 1,727 Black and White girls ages 16 to 18 years who participated in the National Heart, Lung, and Blood Institute's Growth and Health Study. Three years later, women in the depressed groups were more likely to be current smokers, had attained a lower level of education, and reported lower self-worth relative to the nondepressed group. Body dissatisfaction, eating concerns, and loneliness were greater in the depressed groups. Relative to Black women, White women who were moderately depressed during adolescence reported more health care services utilization in young adulthood. Prevention efforts for depressed adolescents should be broadly focused to improve young adult outcomes. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
34.
Anna Beatriz Sabino Ferrari George Azevedo de Oliveira Helena Mannochio Russo Luiza de Carvalho Bertozo Vanderlan da Silva Bolzani Diego Cunha Zied Valdecir Farias Ximenes Maria Luiza Zeraik 《International Journal of Food Science & Technology》2021,56(1):452-460
In this study, the chemical composition, total phenolic content and antioxidant activity (DPPH, ORAC and FRAP assays) of A. subrufescens and P. ostreatus, cultivated with handmade and commercials supplements, were compared. Additionally, the compounds ergosterol, saccharopine, and hexitol were identified in A. subrufescens by HPLC-MS/MS. The antioxidant compound p-coumaric acid and dihexoses was found in both mushroom species. A. subrufescens presented higher total phenolic content (73.8 ± 0.6 mg GAE 100 g−1) and antioxidant activity than P. ostreatus (16.6 ± 0.5 mg GAE 100 g−1). The handmade supplement based on the waste of noble grains presented statistically similar phenolic content to the mushrooms cultivated with commercial ones Spawn Mate II SE (86.1 ± 1.4 and 92.9 ± 0.3 mg GAE 100 g−1, respectively). Therefore, the results support the use of handmade supplements based on agro-wastes as a viable alternative to the use of high-cost commercial ones. 相似文献
35.
Dr. Vladimir O. Talibov Dr. Edoardo Fabini Edward A. FitzGerald Dr. Daniele Tedesco Daniela Cederfeldt Martin J. Talu Moira M. Rachman Filip Mihalic Dr. Elisabetta Manoni Dr. Marina Naldi Dr. Paola Sanese Dr. Giovanna Forte Dr. Martina Lepore Signorile Prof. Xavier Barril Dr. Cristiano Simone Prof. Manuela Bartolini Dr. Doreen Dobritzsch Dr. Alberto Del Rio Prof. U. Helena Danielson 《Chembiochem : a European journal of chemical biology》2021,22(9):1597-1608
SMYD3 is a multifunctional epigenetic enzyme with lysine methyltransferase activity and various interaction partners. It is implicated in the pathophysiology of cancers but with an unclear mechanism. To discover tool compounds for clarifying its biochemistry and potential as a therapeutic target, a set of drug-like compounds was screened in a biosensor-based competition assay. Diperodon was identified as an allosteric ligand; its R and S enantiomers were isolated, and their affinities to SMYD3 were determined (KD=42 and 84 μM, respectively). Co-crystallization revealed that both enantiomers bind to a previously unidentified allosteric site in the C-terminal protein binding domain, consistent with its weak inhibitory effect. No competition between diperodon and HSP90 (a known SMYD3 interaction partner) was observed although SMYD3–HSP90 binding was confirmed (KD=13 μM). Diperodon clearly represents a novel starting point for the design of tool compounds interacting with a druggable allosteric site, suitable for the exploration of noncatalytic SMYD3 functions and therapeutics with new mechanisms of action. 相似文献
36.
This paper addresses the use of high order dissimilarity models in data mining problems. We explore dissimilarities between triplets of nearest neighbors, called dissimilarity increments (DIs). We derive a statistical model of DIs for d-dimensional data (d-DID) assuming that the objects follow a multivariate Gaussian distribution. Empirical evidence shows that the d-DID is well approximated by the particular case d=2. We propose the application of this model in clustering, with a partitional algorithm that uses a merge strategy on Gaussian components. Experimental results, in synthetic and real datasets, show that clustering algorithms using DID usually outperform well known clustering algorithms. 相似文献
37.
Maria Helena Santos Rafael M. Silva Vitor C. Dumont Juliana S. Neves Herman S. Mansur Luiz Guilherme D. Heneine 《Materials science & engineering. C, Materials for biological applications》2013,33(2):790-800
Bovine pericardium is widely used as a raw material in bioengineering as a source of collagen, a fundamental structural molecule. The physical, chemical, and biocompatibility characteristics of these natural fibers enable their broad use in several areas of the health sciences. For these applications, it is important to obtain collagen of the highest possible purity. The lack of a method to produce these pure biocompatible materials using simple and economically feasible techniques presents a major challenge to their production on an industrial scale. This study aimed to extract, purify, and characterize the type I collagen protein originating from bovine pericardium, considered to be an abundant tissue resource. The pericardium tissue was collected from male animals at slaughter age. Pieces of bovine pericardium were enzymatically digested, followed by a novel protocol developed for protein purification using ion-exchange chromatography. The material was extensively characterized by electrophoresis, scanning electron microscopy, energy dispersive X-ray spectroscopy, and infrared spectroscopy. The results showed a purified material with morphological properties and chemical functionalities compatible with type I collagen and similar to a highly purified commercial collagen. Thus, an innovative and relatively simple processing method was developed to extract and purify type I collagen from bovine tissue with potential applications as a biomaterial for regenerative tissue engineering. 相似文献
38.
P. Pereira M. Helena Fino F. Coito M. Ventim-Neves 《Analog Integrated Circuits and Signal Processing》2012,73(1):47-55
In this paper an optimization-based approach for the design of RF integrated inductors is addressed. For the characterisation of the inductor behaviour the double ??-model is used. The use of this model is twofold. On one hand it enables the generation of the inductor characterisation in a few seconds. On the other hand its integration into the optimization procedure is straightforward. For the evaluation of the model element values analytical expressions based on technology parameters as well as on the device geometric characteristics are used. The use of a technology-based methodology for the evaluation of the model parameters grants the adaptability of the model to any technology. The inductor analytical characterization is integrated into an optimization-based tool for the automatic design of RF integrated inductors. This tool uses a modified genetic algorithm (MGA) optimization procedure, which has proved its validation in previous work. Due to the design parameter constraints nature as well as the topology constraints, discrete variables optimization techniques are used. The accuracy of the results is checked against a non-commercial software. 相似文献
39.
Renan Fava Marson Lívia Helena Moreira da Silva Melo Renato Amaro Zângaro Carlos José de Lima 《臭氧:科学与工程》2016,38(5):346-351
The reprocessing of endoscopes is a complex procedure due to their structural design. In the constant search for new antimicrobial substances, recent studies with ozone have yielded great benefits. The present study evaluated the effects of ozonated water used to disinfect endoscopes comparing its efficacy with the conventional technique (2% glutaraldehyde). According to the results obtained, when ozonated water was used (330 mg.min.L?1), induced a 2 log reduction of the viable microorganisms under the conditions tested. Ozonated water was a potent gastrointestinal endoscopic sanitizer, suggesting it is a feasible alternative for disinfection. 相似文献
40.
On extremal dependence: some contributions 总被引:1,自引:1,他引:0
The usual coefficients of tail dependence are based on exceedances of high values. These extremal events are useful and widely used in literature but an adverse situation may also occur with the upcrossing of a high level. In this context we define upcrossings-tail dependence coefficients and analyze all types of dependence coming out. We will prove that these coefficients are related to multivariate tail dependence coefficients already known in literature. We shall see that the upcrossings-tail dependence coefficients have the interesting feature of congregating both ??temporal?? and ??spatial?? dependence. The coefficients of tail dependence can also be applied to stationary sequences and hence measure the tail dependence in time. Results concerning connections with the extremal index and the upcrossings index as well as with local dependence conditions will be stated. Several illustrative examples will be exploited and a small note on inference will be given by presenting estimators derived from the stated results and respective properties. 相似文献