Design and evaluation of a lyophilized liposomal gel of an antiviral drug for intravaginal delivery

Liposomes of antiviral drug(acyclovir) prepared by rotary evaporation method were incorporated into two bioadhesive polymers, carbopol and HPMC and freeze dried to obtain a unit dosage form. The liposomes, liposomal gels and freeze dried rods were evaluated for various parameters. TEM analysis showed the formation of unilamellar liposomes with a mean diameter ranging from 0.9 μm to 1.2 μm. As the cholesterol content increases from 0.5% to 2%w/w, the entrapment efficiency and vesicle size increased. Carbopol gels exhibited higher viscosity, spreadability, mucoadhesiveness than HPMC gels. The redipsersion of freeze dried forms in SVF was found to be slow and its ex‐vivo retention time was found to be 12 hrs while acyclovir gel retained only for 8.25 hrs. The tablet and gel released 96.93±0.15% acyclovir within 6 hrs and 92.31±0.31% by 8 hrs respectively while freeze dried forms could sustain the release upto 12 hrs. From the stability studies the optimum storage condition was found to be 4‐8°C. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 39804.     

Effect of milk protein standardisation using buffalo milk protein co-precipitates on the texture,composition and yield of paneer

Buffalo milk was utilised for preparing paneer samples after standardisation of protein:fat ratio to 0.68 with the addition of buffalo milk protein co-precipitates (BMPC). These paneer samples along with control paneer (from buffalo milk) were analysed for yield, composition, microstructure, sensory, texture profile and protein loss in whey during manufacture. Paneer prepared using BMPC was considerably higher in yield and recovery of total solids, protein and calcium content than control paneer and could withstand the frying conditions in terms of retention of shape and integrity. Texture profile analysis and microstructure evaluation revealed the differences in textural properties of paneer samples prepared using BMPC with control paneer.     

Music footprint recognition via sentiment,identity, and setting identification

Multimedia Tools and Applications - Emotional contagion is said to occur when an origin (i.e., any sensory stimuli) emanating emotions causes the observer to feel the same emotions. In this paper,...     

Intelligent Secured Two-Way Image Transmission Using Corvus Corone Module over WSN

Wireless Personal Communications - Two-way image communication in a wireless channel needs to be viable with channel properties such as transfer speed, energy-effective, time usage, and security...     

Single image super-resolution using coupled dictionary learning and cross domain mapping

Multimedia Tools and Applications - In this paper, a new algorithm for single image super resolution using coupled wavelet and spatial domain dictionary pairs is proposed. The standard deviation...     

Transaction-Centric Reconciliation in Disconnected Client–Server Databases

As mobile computing devices become more and more common, mobile databases are becoming popular. An important feature of these database systems is their ability to allow optimistic replication of data by providing disconnected mobile devices the ability to perform local updates. The key problem to this approach is the reconciliation problem, i.e. the problem of serializing potentially conflicting updates from disconnected clients on all replicas of the database. Reconciliation of conflicting updates is especially critical for disconnected databases where disconnected updates are allowed. We examine some choices for providing solutions to the reconciliation problem. We then present an algorithm that combines multiversion concurrency control schemes on a server with reconciliation of updates from disconnected clients. We also describe a simple but illustrative sample application. Finally we present our conclusions.     

On Two Continuum Armed Bandit Problems in High Dimensions

We consider the problem of continuum armed bandits where the arms are indexed by a compact subset of \(\mathbb {R}^{d}\). For large d, it is well known that mere smoothness assumptions on the reward functions lead to regret bounds that suffer from the curse of dimensionality. A typical way to tackle this in the literature has been to make further assumptions on the structure of reward functions. In this work we assume the reward functions to be intrinsically of low dimension k ? d and consider two models: (i) The reward functions depend on only an unknown subset of k coordinate variables and, (ii) a generalization of (i) where the reward functions depend on an unknown k dimensional subspace of \(\mathbb {R}^{d}\). By placing suitable assumptions on the smoothness of the rewards we derive randomized algorithms for both problems that achieve nearly optimal regret bounds in terms of the number of rounds n.     

Spectrum acquisition strategies adopted by wireless carriers in the USA

This comprehensive review paper integrates concepts and viewpoints to understand the strategies adopted by the wireless carriers in the USA when acquiring mobile wireless spectrum. In the mobile wireless industry, the key industry and business drivers are the investments made by network operators. Of these cost drivers, the most influential on the industry’s dynamics are the capital investments, which include spectrum acquisition investments. This paper provides a review of, and integrates new theories and research results of a group of original papers on spectrum strategies. The concepts and viewpoints are developed based on inferences drawn across these papers, and extensive studies on the evolution of spectrum market and acquisition patterns amongst carriers during the wireless spectrum distributions in the U.S. over the past 15 years.

Monitoring aerobic sludge digestion by online scanning fluorometry

With sludge samples from two wastewater treatment plants, batch experiments of aerobic sludge digestion were conducted under different dissolved oxygen (DO) and solids concentrations. A fluorometer capable of online excitation and emission scanning was used to monitor the digestion process. Three major fluorescence peaks were observed. The peak at excitation/emission maxima of 290/350 nm was attributed to the fluorescence of proteinaceous materials in the sludge, with tryptophan residues being the primary contributor. The sources for the other two peaks (at 370/430 nm and 430/510 nm) remain unknown. The well-known biological fluorescence from reduced nicotinamide adenine dinucleotides (NADH and NADPH), at excitation/emission maxima of 340/460 nm, was found very weak in the aerobic digestion systems studied. It was buried under the broad peak at 370/430 nm and was detectable only in the early stage of the experiment that had the highest solids loading (at 4.8%) and was operated under low DO (0.2-1.0mg/L) conditions. On the other hand, the profile of the protein fluorescence (PF) correlated well with that of the volatile solids (VS) reduction in all the experiments. A semi-empirical exponential decay function was developed, which described well the profiles of both normalized VS and normalized PF. The feasibility of following the real-time performance of aerobic sludge digestion by monitoring PF was clearly demonstrated.     

Service multinationals: Their past,present, and future

Abstract and Key Results