Critical epistemologies and gender issues in initial teacher education

The view that epistemological issues are central to developing a gender critical initial teacher education is explored. Particular reference is made to current government conceptualisations, and the associated assessment practices in England and Wales that are predicated on a technicist model of teaching. A critique of this model is put forward, and an alternative offered involving the self-reflective agent and a dialogic curriculum. Tentative suggestions are made for re-visioning practice     

The Topp–Leone Lomax (TLLo) Distribution with Applications to Airbone Communication Transceiver Dataset

Wireless Personal Communications - The Lomax distribution was extended in this paper using the Topp–Leone family of distributions. Some of its specific structural properties were established...     

Conjugation of Dasatinib with MHI-148 Has a Significant Advantageous Effect in Viability Assays for Glioblastoma Cells

We hypothesized that conjugation of the near-infrared dye MHI-148 with the anti-leukemia drug dasatinib might produce a potential theranostic for glioblastoma. In fact, the conjugate was found to bind the kinases Src and Lyn, and to inhibit the viability of a glioblastoma cell line with significantly greater potency than dasatinib alone, MHI-148 alone, or a mixture of dasatinib and MHI-148 at the same concentration. It was also used to successfully image a subcutaneous glioblastoma tumor in vivo.     

Fast and Optimal Path Planning Algorithm (FAOPPA) for a Mobile Robot

Wireless Personal Communications - The compressive sensing method presents itself as a promising technique in many fields specially for the Internet of Things and Wireless sensor networks...     

The MC68332 microcontroller

The total-system goals, CPU design goals, and modular design approach of the high-performance MC68332 microcontroller are described. The features of the system integration module, queued serial module, and standby RAM are summarized. The CPU and time processor modules are discussed in detail     

A comparison of the boundary element and superposition methods

For some time now, the Boundary Integral Equation (BIE) Method or as it is alternately called the Boundary Element Method (BEM) has been hailed as the technique best suited to problems in elasticity and related fields, both for accuracy and efficiency. The authors demonstrate by example that this is not the case. A much simpler and more versatile technique, the Superposition Method (SUP), is introduced and is shown to outperform BEM in both areas. Followed by a discussion of the merits and drawbacks of each method, compact computer programs for both BEM and SUP and numerical results for nine different example problems are presented to support the authors' claim.     

Restrictions on the singularity method applied to elasticity

The choice of which fundamental singular solutions to use as basis functions in the so-called singularity method applied to elasticity appears to be restricted by boundary condition types and region geometry. In practice, only the point load solution is consistently reliable but even it fails in certain instances when the elastic body is not a convex region and almost always when the region is not simply connected. Fortunately, all multiply connected regions can be partitioned into simply-connected (although not always convex) ones. A method for doing this is presented along with examples of fundamental solutions which do not work in the singularity method.     

Delta T 14/Delta D 15 Azotobacter vinelandii ferredoxin I: creation of a new CysXXCysXXCys motif that ligates a [4Fe-4S] cluster

In clostridial-type ferredoxins, each of the two [4Fe-4S]2+/+ clusters receives three of its four ligands from a CysXXCysXXCys motif. Azotobacter vinelandii ferredoxin I (AvFdI) is a seven-iron ferredoxin that contains one [4Fe-4S]2+/+ cluster and one [3Fe-4S]+/0 cluster. During the evolution of the 7Fe azotobacter-type ferredoxins from the 8Fe clostridial-type ferredoxins, one of the two motifs present changed to a CysXXCysXXXXCys motif, resulting in the inability to form a 4Fe cluster and the appearance of a 3Fe cluster in that position. In a previous study, we were unsuccessful in using structure as a guide in designing a 4Fe cluster in the 3Fe cluster position of AvFdI. In this study, we have reversed part of the evolutionary process by deleting two residues between the second and third cysteines. UV/Vis, CD, and EPR spectroscopies and direct electrochemical studies of the purified protein reveal that this DeltaT14/DeltaD15 FdI variant is an 8Fe protein containing two [4Fe-4S]2+/+ clusters with reduction potentials of -466 and -612 mV versus SHE. Whole-cell EPR shows that the protein is present as an 8Fe protein in vivo. These data strongly suggest that it is the sequence motif rather than the exact sequence or the structure that is critical for the assembly of a 4Fe cluster in that region of the protein. The new oxygen-sensitive 4Fe cluster was converted in partial yield to a 3Fe cluster. In known ferredoxins and enzymes that contain reversibly interconvertible [4Fe-4S]2+/+ and [3Fe-4S]+/0 clusters, the 3Fe form always has a reduction potential ca. 200 mV more positive than the 4Fe cluster in the same position. In contrast, for DeltaT14/DeltaD15 FdI, the 3Fe and 4Fe clusters in the same location have extremely similar reduction potentials.     

Bioethics for clinicians: 14. Ethics and genetics in medicine

Information about a patient's inherited risk of disease has important ethical and legal implications in clinical practice. Because genetic information is by nature highly personal yet familial, issues of confidentiality arise. Counselling and informed consent before testing are important in view of the social and psychological risks that accompany testing, the complexity of information surrounding testing, and the fact that effective interventions are often not available. Follow-up counselling is also important to help patients integrate test results into their lives and the lives of their relatives. Genetic counselling should be provided by practitioners who have up-to-date knowledge of the genetics of and the tests available for specific diseases, are aware of the social and psychological risks associated with testing, and are able to provide appropriate clinical follow-up. Some physicians may elect to refer patients for genetic counselling and testing. However, it is inevitable that all physicians will be involved in long-term follow-up both by monitoring for disease and by supporting the integration of genetic information into patients' lives.     

Reviews

VISUAL SIMULATION: A Users Guide for Architects, Engineers and Planners, Stephen R. J. Sheppard, Van Nostrand Reinhold, New York/Chapman Hall, London, 1989, 215pp, ISBN 0-442-27827-6, £30.00.

MAPS OF MEANING: An introduction to Cultural Geography, Peter Jackson, London, Unwin Hyman, 1989, ISBN 0-04-445366-3, 213pp., £30.00 HB, £8.95 PB.

THE POWER OF PLACE: BRINGING TOGETHER GEOGRAPHICAL AND SOCIOLOGICAL IMAGINATIONS,John A. Agnew and James S. Duncan (Eds), Boston: Unwin Hyman, 1989, 231pp., ISBN 0-04-445281. $28.00 HB.

DESIGN FOR MOUNTAIN COMMUNITIES: A LANDSCAPE AND ARCHITECTURAL GUIDE by Sherry Dorward, London: Chapman and Hall, 1989, £31.50. 0-442-22095-2.