Effects of physiological arousal level, frustration, and task complexity on performance.

This paper investigates the effects of initial heart-rate level, frustration, and task complexity on digit-symbol performance. Low (LD) and high (HD) heart-rate Ss worked on a digit-symbol problem immediately before and after a frustration manipulation which raised heart rate about 20 beats/min. The results indicated that HD Ss achieved higher initial performance scores than LD Ss on tasks of relatively low complexity; however, following frustration LD Ss manifested a significantly greater increment in performance than HD Ss. The latter group showed a trend toward a decrement in performance. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Phase I studies with Baker's Antifol (BAF) (NSC 139105)

Phase I studies were conducted in 58 adult cancer patients with Baker's Antifol (BAF), a new active-site directed inhibitor of dihydrofolate reductase. Dose escalation ranged from 10 to 250 mg/m2/day X 5 days and courses of treatment were repeated every 2-3 weeks. Biologic effects were observed mostly at doses greater than 100 mg/m2/day X 5 days. The patients developed myelosuppression during 19% of the trials. Other types of toxicity were dermatitis in 12 to 30% and stomatitis in 7 to 38% of the trials. Toxicity was directly related to the impairment of the patient's liver function. Two partial responses (in a patient with adenocarcinoma of the lung and a patient with transitional cell carcinoma of the bladder) occurred. BAF is an active new chemotherapeutic agent which deserves further clinical trials in patients with various malignancies.     

Recognition by constructive neural algorithms

The usability of the constructive neural algorithms as pattern classifiers is investigated. It is pointed out that the unboundedness of the decision regions formed by most neural recognizers leads to substantial limitations of the generalization capabilities of these nets. We specify a constructive neural recognizer that forms bounded decision regions, and report the results of this algorithm on a series of benchmark problems that resemble the usual pattern recognition problems.     

Effects of increased heart rate on intellectual performance.

A significant correlation found in a pilot study between heart rate and digit Symbol performance was utilized to investigate effects of type of arousal induction on performance. 60 Ss were arranged in a 3 X 2 factorial design, divided into high and low drive via heart rate. Ss first performed on a Digit Symbol task; followed by a frustrating experience, physical exertion, or nonfrustrating task; followed by readministration of an alternate form of the 1st Digit Symbol problem. The results showed that the relation between activation and performance, in most instances followed the hypothetical inverted U function. (17 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Recognising Simple Behaviours Using Time-Delay RBF Networks

This paper presents experiments using a radial basis function variant of the time-delay neural network with image sequences of human faces. The network is shown to be able to learn simple behaviours based on y-axis head rotation and generalise on different data. The network model's suitability for future dynamic vision applications is discussed.     

Knowing where things are parahippocampal involvement in encoding object locations in virtual large-scale space

The availability of a number of new immunosuppressive drugs has resulted in significant improvements in the outcome of kidney transplantation. Currently 1-year graft survival rate for cadaver kidney transplants is approximately 85%. A number of new agents are presently in clinical studies. This article reviews the currently available agents and examines various aspects of induction and maintenance immunosuppressive therapy, and the treatment of acute rejection episodes. In addition, the agents currently in clinical trials and future directions in immunosuppressive therapy are discussed.