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61.
Akira Heya Toshiharu Minamikawa Shigehira Minami Hironobu Umemoto Naoto Matsuo 《Thin solid films》2008,516(5):553-557
A Roll-to-roll type catalytic chemical vapor deposition (Cat-CVD) apparatus was developed for the application to flexible organic light-emitting diode (OLED) displays and packaging. Silicon nitride (SiNx) films were prepared by this roll-to-roll type apparatus at temperatures below 60 °C. It was found that these SiNx films are highly moisture resistant, and the water vapor transmission rate (WVTR) on plastic substrates could be lowered to 0.01 g/m2 day. Roll-to-roll type Cat-CVD is one of the most promising methods for the preparation of barrier films for OLED displays and packaging. 相似文献
62.
A novel derivative of vitamin E, vitamin E glucoside, was synthesized from 2-hydroxymethyl-2,5,7,8-tetramethylchroman-6-ol
and maltose in a solution containing DMSO by transglycosylation with α-glucosidase from Saccharomyces species. The glycosylated product was identified as 2-(α-d-glucopyranosyl)methyl-2,5,7,8,-tetramethylchroman-6-ol (TMG) by mass spectrometry and nuclear magnetic resonance spectroscopy.
The optimal pH of transglycosylation was 5.5, and the yield of TMG increased as the concentration of maltose increased. IMG
has high solubility in water (>1×103 mg/mL). The 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity of TMG was found to be nearly the same as those of
α-tocopherol, Trolox (2-carboxy-2,5,7,8-tetramethylchroman-6-ol), and ascorbic acid. 相似文献
63.
Haruka Kuriyama Satoshi Fukushima Toshihiro Kimura Hisashi Kanemaru Azusa Miyashita Etsuko Okada Yosuke Kubo Satoshi Nakahara Aki Tokuzumi Yuki Nishimura Ikko Kajihara Katsunari Makino Jun Aoi Shinichi Masuguchi Hirotake Tsukamoto Takashi Inozume Rong Zhang Tetsuya Nakatsura Yasushi Uemura Satoru Senju Hironobu Ihn 《International journal of molecular sciences》2021,22(4)
We have established an immune cell therapy with immortalized induced pluripotent stem-cell–derived myeloid lines (iPS-ML). The benefits of using iPS-ML are the infinite proliferative capacity and ease of genetic modification. In this study, we introduced 4-1BBL gene to iPS-ML (iPS-ML-41BBL). The analysis of the cell-surface molecules showed that the expression of CD86 was upregulated in iPS-ML-41BBL more than that in control iPS-ML. Cytokine array analysis was performed using supernatants of the spleen cells that were cocultured with iPS-ML or iPS-ML-41BBL. Multiple cytokines that are beneficial to cancer immunotherapy were upregulated. Peritoneal injections of iPS-ML-41BBL inhibited tumor growth of peritoneally disseminated mouse melanoma and prolonged survival of mice compared to that of iPS-ML. Furthermore, the numbers of antigen-specific CD8+ T cells were significantly increased in the spleen and tumor tissues treated with epitope peptide-pulsed iPS-ML-41BBL compared to those treated with control iPS-ML. The number of CXCR6-positive T cells were increased in the tumor tissues after treatment with iPS-ML-41BBL compared to that with control iPS-ML. These results suggest that iPS-ML-41BBL could activate antigen-specific T cells and promote their infiltration into the tumor tissues. Thus, iPS-ML-41BBL may be a candidate for future immune cell therapy aiming to change immunological “cold tumor” to “hot tumor”. 相似文献
64.
Thai Son Hoang Hironobu Kuruma David Basin Jean-Raymond Abrial 《Science of Computer Programming》2009,74(11-12):879-899
We present a formal development in Event-B of a distributed topology discovery algorithm. Distributed topology discovery is at the core of several routing algorithms and is the problem of each node in a network discovering and maintaining information on the network topology. One of the key challenges in developing this algorithm is specifying the problem itself. We provide a specification that includes both safety properties, formalizing invariants that should hold in all system states, and liveness properties that characterize when the system reaches stable states. We prove these properties by appropriately combining proofs of invariants, event refinement, event convergence, and deadlock freedom. The combination of these features is novel and should be useful for formalizing and developing other kinds of semi-reactive systems, which are systems that react to, but do not modify, their environment. Our entire development has been formalized and machine checked using the Rodin tool. 相似文献
65.
The aberration of a multipole Wien filter for energy-filtered x-ray photoemission electron microscopy was analyzed and the optimized Fourier components of the electric and magnetic fields for the third-order aperture aberration corrections were obtained. It was found that the third-order aperture aberration correction requires 12 electrodes and magnetic poles. 相似文献
66.
The staple fibers of Ca alginate or alginic acid were found to have interfiber self-bonding, which allowed us to make papers composed of fibers with homogeneous fiber diameter and fiber length without binders. The analysis of the effect of the molecular weight (MW) and fiber diameter on physical properties of the sheets showed that strength factors, except zero span breaking length and tear index, increased with increase of MW of alginic acid up to 6 × 105 dalton. The folding endurance was the most sensitive to MW, requiring a MW of 5 × 105 dalton or higher to reach the level of 10 folds. The breaking length of alginate fiber papers ranged from 2.0 to 3.5 km and was higher than that of the corresponding free acid fiber sheets. Investigation of the effect of fiber length indicated that the folding endurance increased almost linearly with increase in fiber length but that the breaking length and tear index were maximum at a fiber length of 3.0 mm, suggesting that these factors were mainly influenced by sheet formation. The paper formability of the metallic salts of alginate fiber was as follows: Ca2+ > Ba2+ > Al3+ > > Fe3+. The admixture of acidic polysaccharides, such as pectin and κ -carrageenan with Na alginate, also made it possible to spin continuous yarn. Papers obtained from the admixed fibers had higher bulk density and Young's modulus by 1.5–1.8 times and were very transparent, just like glassine paper. X-ray microanalysis showed that the Ca alginate fiber had no skin-core structure, homogeneously distributing Ca2+ in whole fiber. 相似文献
67.
用准急压冷法制成Fe_2O_3-SrO-TeO_2系半导体玻璃并对其直流电导率进行了测定。玻璃形成范围为(以摩尔计);0≤Fe_2O_3≤23%;0≤SrO≤18%;75%≤TeO_2<100%。通过Seebeck系数的测定确认Fe_2O_3-SrO-TeO_2系玻璃为n型半导体玻璃。200℃的直流电导率为3.72×10 ̄(-5)~1.82×10 ̄(-6)S·cm ̄(-1)。直流电导率随着Fe_2O_3含量的增加而增加,165℃时的载流子迁移率和浓度分别为1.12×10 ̄(-9)~3.67×10 ̄-7cm ̄2·V ̄(-1)·S ̄(-1)和2.17×10 ̄(21)~8.33×10 ̄19cm ̄(-3).讨论的结果表明Fe_2O_3-SrO-TeO_2系玻璃的电导机理符合小极化子跳越理论。 相似文献
68.
Kakuta Noriyoshi Kudo Yosuke Rachi Hironobu Ohkita Hironobu Mizushima Takanori 《Topics in Catalysis》2007,42(1-4):377-380
Oxygen storage profile on CeO2–ZrO2 mixed oxide (CZ) has been observed by periodic injections of O2 pulse. The reduction behavior of oxygen after the O2 pulse injection was also investigated using Temperature Programmed Reduction (TPR) method. The oxygen storage profiles of
the CZ catalyst with κ-CeZrO4 phase indicate that the solid solution phase facilitates to diffuse oxygen into the bulk, and TPR profiles suggest that oxygen
is preferentially stored by the reaction with Ce3+ species derived from CeO2 phase compared with those from the κ-CeZrO4 phase, especially at low temperatures. 相似文献
69.
Hironobu Sunami Tsutomu Morimura Yoshiaki Terumichi Masahito Adachi 《Multibody System Dynamics》2012,27(3):321-349
Preventing railway vehicles from derailing is the most important earthquake countermeasure. Similarly, formulating measures
to prevent vehicles from deviating from the track in the event of a derailment is an extremely important secondary measure
for minimizing the risk of fatalities. The authors have developed a post-derailment stopper, which prevents derailed vehicles
from veering off the track by catching on guard rails. We conducted running tests under derailment conditions using real bogies
and tracks to develop the stopper and evaluate its efficacy. Since we observed peculiar motions of the bogie frame when the
stopper was attached during running tests, we propose a 15 DOF vehicle dynamics model in order to discuss, in particular,
the motion of the bogie frame and the stopper under derailment conditions. In this model, we give degrees of freedom to the
motors mounted on the bogie frame because contact between the stopper and the guards was observed repeatedly during running
tests. In addition, in this simulation of a derailed vehicle, static equilibrium conditions are calculated using the data
obtained from running tests prior to the time history analysis. We evaluated the validity of the proposed model by comparing
the calculated results with measured data. 相似文献
70.