Real-time Design Constraints in Implementing Active Vibration Control Algorithms

Although computer architectures incorporate fast processing hardware resources, high performance real-time implementation of a complex control algorithm requires an efficient design and software coding of the algorithm so as to exploit special features of the hardware and avoid associated architecture shortcomings. This paper presents an investigation into the analysis and design mechanisms that will lead to reduction in the execution time in implementing real-time control algorithms. The proposed mechanisms are exemplified by means of one algorithm, which demonstrates their applicability to real-time applications. An active vibration control (AVC) algorithm for a flexible beam system simulated using the finite difference (FD) method is considered to demonstrate the effectiveness of the proposed methods. A comparative performance evaluation of the proposed design mechanisms is presented and discussed through a set of experiments.     

Method for determining a dynamical state-space model for control of thermal MEMS devices

A method is presented for determining lumped dynamical models of thermal microelectromechanical systems (MEMS) devices for purposes of feedback control. As a case study, an electrothermal actuator is used. The physical properties and a set of assumptions are used to determine the basic structure of the dynamical model, which requires the development of the electrical, thermal, and mechanical dynamics. The importance of temperature-dependent parameters is emphasized for dynamical modeling for purposes of feedback control. To confront temperature dependence in a practical yet effective manner, an average temperature is introduced to preserve the energy balance inside the structure. This allows the development of a practical method that combines structure of the model, through the average body temperature, with finite element analysis (FEA) in novel way to perform system identification and identify the unknown parameters. The result is a lumped dynamical model of a MEMS device that can be used for the design of feedback control systems. We compare computer simulated results using the dynamical model with experimental behavior of the actual device to show that our procedure indeed generates an accurate model. This dynamical model is intended for further synthesis of driving signal and control system but also gives a qualitative insight into the relationship between device's geometry and its behavior. The method enables fast development of the model by conducting relatively few static FEA and is verifiable with dynamic experimental results even when temperature measurements are not available.     

Bioreduction of Hexavalent Chromium in Flow-Through Quartz Sand Columns

Hexavalent chromium (Cr(VI)) contamination of soil and groundwater is a major environmental concern for some industrial sites and most of the U.S. Department of Energy sites. Cr(VI) is toxic and fairly mobile in groundwater. Bioreduction of Cr(VI) to less toxic and less mobile Cr(III) is considered to be a feasible option. Among the Cr(VI) reducing bacteria, Shewanella oneidensis MR-1 (MR-1) has been shown to be effective in metal reduction under anaerobic conditions. Data on bioreduction of Cr(VI) by MR-1 in a flow-through soil column that better approximates the subsurface condition are not available. The objective of this research project was to study the bioreduction of Cr(VI) by MR-1 in a continuous-flow quartz sand column system. MR-1 was found to be very effective in reducing Cr(VI) to Cr(III) for concentrations ranging from 0.055 mM (2.85?mg/L) to 0.006 mM (0.31?mg/L). The amount of Cr(VI) reduced prior to its breakthrough was found to be inversely proportional to its concentration in the feed due to increased inhibition of microbial activity and a residual reduction of 20–45% of Cr(VI) was observed even after its breakthrough.     

Combined heat and mass transfer in natural convection flow from a vertical wavy surface

Summary In the present paper, effects of combined buoyancy forces from mass and thermal diffusion by natural convection flow from a vertical wavy surface have been investigated using the implicit finite difference method. Here we have focused our attention on the evolution of the surface shear stress,f(0), rate of heat transfer,g(0), and surface concentration gradient,h(0) with effect of different values of the governing parameters, such as the Schmidt number Sc ranging from 7 to 1500 which are appropriate for different species concentration in water (Pr=7.0), the amplitude of the waviness of the surface ranging from 0.0 to 0.4 and the buoyancy parameter,w, ranging from 0.0 to 1.Notation C species concentration in the boundary layer - C species concentration of the ambient fluid - C _w species concentration at the surface - D chemical molecular diffusivity - f dimensionless stream function - g acceleration due to gravity - Gr _x local modified Grashof number - N ratio of the buoyancy forces due to the temperature difference and the concentration difference - p pressure of the fluid - T temperature of the fluid in the boundary layer - T temperature of the ambient fluid - T _w temperature at the surface - u, v thex- andy-components of the velocity field - x, y axis in the direction along and normal to the plate Greek symbols thermal diffusivity - _T volumetric coefficient of thermal expansion - _C volumetric coefficient of expansion with concentration - stream function - nondimensional similarity variable - x/L - density of the ambient fluid - v kinematic coefficient of viscosity - stream function - dimensionless skin friction - fluid viscosity     

Functional analysis of a rickettsial OmpA homology domain of Shigella flexneri icsA

Shigella flexneri is a gram-negative bacterium that causes diarrhea and dysentery by invasion and spread through the colonic epithelium. Bacteria spread by assembling actin and other cytoskeletal proteins of the host into "actin tails" at the bacterial pole; actin tail assembly provides the force required to move bacteria through the cell cytoplasm and into adjacent cells. The 120-kDa S. flexneri outer membrane protein IcsA is essential for actin assembly. IcsA is anchored in the outer membrane by a carboxy-terminal domain (the beta domain), such that the amino-terminal 706 amino acid residues (the alpha domain) are exposed on the exterior of the bacillus. The alpha domain is therefore likely to contain the domains that are important to interactions with host factors. We identify and characterize a domain of IcsA within the alpha domain that bears significant sequence similarity to two repeated domains of rickettsial OmpA, which has been implicated in rickettsial actin tail formation. Strains of S. flexneri and Escherichia coli that carry derivatives of IcsA containing deletions within this domain display loss of actin recruitment and increased accessibility to IcsA-specific antibody on the surface of intracytoplasmic bacteria. However, site-directed mutagenesis of charged residues within this domain results in actin assembly that is indistinguishable from that of the wild type, and in vitro competition of a polypeptide of this domain fused to glutathione S-transferase did not alter the motility of the wild-type construct. Taken together, our data suggest that the rickettsial homology domain of IcsA is required for the proper conformation of IcsA and that its disruption leads to loss of interactions of other IcsA domains within the amino terminus with host cytoskeletal proteins.     

All-optical switching in a distributed-feedback GaInAsP waveguide

The characteristics of all-optical switching in a waveguide device with a distributed-feedback structure were experimentally investigated. The device was composed of a strip-loaded GaInAsP/InP waveguide and a distributed-feedback structure, which was fabricated by a combination of reactive-ion etching and electron-beam exposure. In the experiments, several optical switching operations were demonstrated. In particular, the all-optical set-reset operation and threshold operation were obtained.     

Anterior rhinomanometry in nasal allergen challenges

Even simple and relatively safe provocation procedures like nasal allergen challenges, should aim to allow detection of positivity with the less possible discomfort to the patient. The objective of this work was to evaluate if the use of rhinomanometric measurements during nasal provocation procedures could allow a decrease in the total administered allergen dose, causing less symptoms to the patients but without increasing the number of false-negatives, comparatively to clinical scores or nasal peak-flow measurements. Our results showed that performing rhinomanometric measurements during nasal HDM challenge procedures can lead in many patients to a reduction in the total dose of allergen administered during the challenge, without loss of sensitivity or specificity. This allergen dose reduction translates in less time consumed during the provocation and less patients' discomfort.     

Disposition of 14C-eptifibatide after intravenous administration to healthy men

Eptifibatide, a synthetic peptide inhibitor of the platelet glycoprotein IIb/IIIa receptor, has been studied as an antithrombotic agent in a variety of acute ischemic coronary syndromes. The purpose of the present study was to characterize the disposition of 14C-eptifibatide in man after a single intravenous (i.v.) bolus dose. 14C-Eptifibatide (approximately 50 microCi) was administered to eight healthy men as a single 135-microgram/kg i.v. bolus. Blood, breath carbon dioxide, urine, and fecal samples were collected for up to 72 hours postdose and analyzed for radioactivity by liquid scintillation spectrometry. Plasma and urine samples were also assayed by liquid chromatography with mass spectrometry for eptifibatide and deamidated eptifibatide (DE). Mean (+/- SD) peak plasma eptifibatide concentrations of 879 +/- 251 ng/mL were achieved at the first sampling time (5 minutes), and concentrations then generally declined biexponentially, with a mean distribution half-life of 5 +/- 2.5 minutes and a mean terminal elimination half-life of 1.13 +/- 0.17 hours. Plasma eptifibatide concentrations and radioactivity declined in parallel, with most of the radioactivity (82.4%) attributed to eptifibatide. A total of approximately 73% of administered radioactivity was recovered in the 72-hour period following 14C-eptifibatide dosing. The primary route of elimination was urinary (98% of the total recovered radioactivity), whereas fecal (1.5%) and breath (0.8%) excretion was small. Eptifibatide is cleared by both renal and nonrenal mechanisms, with renal clearance accounting for approximately 40% of total body clearance. Within the first 24 hours, the drug is primarily excreted in the urine as unmodified eptifibatide (34%), DE (19%), and more polar metabolites (13%).     

Blood and plasma selenium levels and GSH-Px activities in patients with arterial hypertension and chronic heart disease

Among the 57 monoclonal antibodies analyzed within the T-cell group of the Second International Swine CD Workshop, one mAb fell within cluster T14a that included the CD6 standard a38b2 (No. 175). The new mAb MIL8 (No. 082) and a38b2 both precipitated from activated T-cells a 150 kDa monomeric protein. Staining patterns on the various cell types were similar. There was no inhibition of binding of either mAb to peripheral blood T-cells with the opposite mAb. The new mAb, MIL8, reacts with a separate epitope on porcine wCD6.     

Necrotizing fasciitis

Necrotizing fasciitis is a rare soft tissue infection with a high rate of mortality. Decreased capacity of the immune response is the overall disposing factor. Necrotizing fasciitis can develop very rapidly, and a rapid diagnosis and aggressive surgery provides the best prognosis.