邹庄井田3_2煤层煤与瓦斯突出地质预测

根据矿井已揭露瓦斯地质参数信息,运用煤与瓦斯突出地质预测方法,结合数量化理论,建立了矿井32煤层瓦斯地质预测模型及瓦斯地质区划预测指标体系,从而提高了瓦斯防治的前瞻性、针对性。     

Improved active‐diode circuit used in voltage doubler

An improved active‐diode circuit, which makes use of positive feedback to achieve fast on/off transition, is presented in this paper. The proposed active‐diode circuit can be embedded into a voltage doubler to replace the commonly used dead‐time circuit and to eliminate reverse current. In addition, the relationship between oscillation frequency, boosting and output capacitances, load‐ and on‐resistances of the power switch and the output voltage is analysed, to investigate a methodology to retain high voltage gain of a voltage doubler. The proposed active‐diode circuit is applied to a voltage doubler implemented in a commercial 0.35‐µm process with threshold voltage of about 0.68 V. The input voltage, maximum output current and oscillation frequency of the voltage doubler are 1 V, 1 mA and 0.4 MHz, respectively. Moreover, the used boosting and output capacitances are 22 nF. The highest power efficiency achieved is 83% at a load current of 0.47 mA. Copyright © 2010 John Wiley & Sons, Ltd.     

A Fully Differential Band-Selective Low-Noise Amplifier for MB-OFDM UWB Receivers

A band-selective low-noise amplifier (BS-LNA) for multiband orthogonal frequency-division multiplexing ultra-wide-band (UWB) receivers is presented. A switched capacitive network that controls the resonant frequency of the LC load for the band selection is used. It greatly enhances the gain and noise performance of the LNA in each frequency band without increasing power consumption. Moreover, a fully differential configuration is employed to suppress the common-mode switching noise that is generated during the band transition interval. Fabricated in a 0.18-$mu{hbox {m}}$ CMOS process, the BS-LNA achieves a peak power gain of 16 dB, a minimum noise figure of 2.74 dB, and an third-order input intercept point of $-$8.8 dBm at a current consumption of 7.95 mA from a 1.5-V supply. Little performance degradation is observed when the current consumption is reduced by half. The experimental results also show a worst-case band-switching time of less than 3.4 ns, with a peak switching noise voltage of less than 70 $mu hbox{V}$ at the output.      

Dietary calcium decreases plasma cholesterol by down‐regulation of intestinal Niemann–Pick C1 like 1 and microsomal triacylglycerol transport protein and up‐regulation of CYP7A1 and ABCG 5/8 in hamsters

Scope: It has been shown that calcium supplementation favorably modifies plasma lipoprotein profile in postmenopausal women. The present study investigated the interaction of dietary calcium with genes of transporters, receptors and enzymes involved in cholesterol metabolism. Methods and results: Forty‐eight ovariectomized hamsters were fed one of the four diets containing 0, 2, 6 and 8 g calcium per kg. Plasma total cholesterol (TC), triacylglycerols (TG), and non‐high density lipoprotein cholesterol were dose‐dependently decreased, whereas high‐density lipoprotein cholesterol (HDL‐C) was dose‐dependently increased with the increasing dietary calcium levels. Dietary calcium had no effect on protein mass of hepatic sterol regulatory element binding protein‐2 (SREBP), liver X receptor‐alpha (LXR), 3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGR), LDL receptor (LDLR) and cholesterol‐7α‐hydroxylase (CYP7A1). However, dietary calcium up‐regulated the mRNA levels of hepatic CYP7A1 and intestinal ATP binding cassette transporters (ABCG5/8) whereas it down‐regulated the intestinal Niemann‐Pick C1 like 1 (NPC1L1) and microsomal triacylglycerol transport protein (MTP). In addition, dietary calcium increased the activity of intestinal acyl coenzyme A: cholesterol acyltransferase 2, while it decreased plasma cholesteryl ester transport protein (CETP). Conclusion: Beneficial modification of lipoprotein profile by dietary calcium was mediated by sequestering bile acid absorption and enhancing excretion of fecal cholesterol, via up‐regulation of mRNA CYP7A1 and intestinal ABCG 5/8 with down‐regulation of mRNA NPC1L1 and MTP.     

CO2 laser-assisted preparation of transparent Eu2Ti2O7 thin films

We present a laser-assisted preparation of transparent europium-titanate Eu₂Ti₂O₇ thin films with tailored structural and optical properties. We have evaluated the effects of the irradiation time on the structural and the optical properties of the films. This approach allows the preparation of nanocrystalline crack-free films and micro patterns. The amorphous thin films were prepared by a sol-gel method. The films were annealed by a CO₂ laser beam for various time intervals. The laser irradiation induced a crystallization process that resulted in the formation of Eu₂Ti₂O₇ nanocrystals. The nanocrystals regularly grew with increasing irradiation time reaching the size from 25?nm to 45?nm. A film of a thickness 480?nm exhibited an optical transmission of 91.9% that is close to the maximal theoretical limit. The film's refractive index at 632?nm was 2.26. A micrometric pattern was prepared by a direct laser writing followed by a wet chemical etching. Feasibility of the demonstrated approach, together with the high film's quality, and europium-titanate chemical resistivity open up many opportunities for advanced applications. The approach can be used for a preparation of protective coatings and integrated photonic devices such as planar optical waveguides and couplers.     

Electrically Active States of Charge Capture and Transfer Causing Slow Recombination in Thallium-Bromide Crystals at Low Temperatures

TlBr single crystals grown by the Bridgman–Stockbarger method are studied. It is established that frozen-conductivity effects manifest themselves under interband excitation by light at temperatures below 200 K. Herewith, clearly pronounced superlinear dependences of the induced photoconductivity on the strength of the applied electric field manifest themselves. The results of studying thermally stimulated conductivity evidence that these phenomena can be associated with the filling of trap states with thermal activation energies of 0.08–0.12 eV. This state can be removed due to thermal quenching at temperatures of ?180 K because of the emptying of energy states with an activation energy of 0.63–0.65 eV filled after optical generation.     

Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells

Mitochondrial metabolism is an attractive target for cancer therapy. Reprogramming metabolic pathways can potentially sensitize tumors with limited treatment options, such as triple-negative breast cancer (TNBC), to chemo- and/or radiotherapy. Dichloroacetate (DCA) is a specific inhibitor of the pyruvate dehydrogenase kinase (PDK), which leads to enhanced reactive oxygen species (ROS) production. ROS are the primary effector molecules of radiation and an increase hereof will enhance the radioresponse. In this study, we evaluated the effects of DCA and radiotherapy on two TNBC cell lines, namely EMT6 and 4T1, under aerobic and hypoxic conditions. As expected, DCA treatment decreased phosphorylated pyruvate dehydrogenase (PDH) and lowered both extracellular acidification rate (ECAR) and lactate production. Remarkably, DCA treatment led to a significant increase in ROS production (up to 15-fold) in hypoxic cancer cells but not in aerobic cells. Consistently, DCA radiosensitized hypoxic tumor cells and 3D spheroids while leaving the intrinsic radiosensitivity of the tumor cells unchanged. Our results suggest that although described as an oxidative phosphorylation (OXPHOS)-promoting drug, DCA can also increase hypoxic radioresponses. This study therefore paves the way for the targeting of mitochondrial metabolism of hypoxic cancer cells, in particular to combat radioresistance.     

Effect of carbon nanoparticle reinforcement on mechanical and thermal properties of silicon carbide ceramics

This research presents an analysis of the influence of graphene reinforcement on the thermal and mechanical properties of silicon carbide ceramics, at 2.5% (wt%) graphene content. The SiC composites, containing various carbon nanofillers (graphene oxide and graphene nanoparticles), were sintered by the classical two stage spark plasma sintering method. Two current modes were used, the continuous mode and the pulsed current mode. The results from photothermal radiometry and investigations of the mechanical properties showed that graphene additives significantly improve the thermal properties and toughness of material, sintered from a SiC powder. An 45% growth in the toughness was observed, which increased from 1.21 to 1.75?MPa/m^1/2. The thermal diffusivity value also increased from 0.60 to 0.71?cm²/s and giving an improvement in thermal properties of 18%. The friction coefficient reached 7% giving an increase in value from 0.62 to 0.66. Microscopic investigations supported the photothermal radiometry (PTR) results. Whilst, thermal imaging revealed homogeneity of the local thermal properties of the products fabricated from the starting SiC powder.     

Broad learning for nonparametric spatial modeling with application to seismic attenuation

Spatial modeling is a core element in geographical information science. It incorporates geographic information to construct the relationship for interpreting the behavior of spatial phenomena. In this paper, a broad learning framework for nonparametric spatial modeling is presented. Broad learning overcomes the obstacle of expensive computational consumption in deep learning and provides a powerful computationally efficient alternative. In contrast to the deep learning architecture that is configured with stacks of hierarchical layers, broad learning networks are established in a flat manner that can be flexibly reconfigured with the inherited information from the trained network. To develop the broad learning network, a simple prototype network is established as the initial trial and it is modified incrementally to enhance its data fitting capacity. Consequently, complex relationship of unstructured spatial data can be modeled efficiently. To demonstrate the efficacy and applicability of the broad learning framework, we will present a simulated example and a real application using the strong ground motion records on the 2008 great Wenchuan earthquake.