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排序方式: 共有552条查询结果,搜索用时 15 毫秒
451.
Francesca Camponogara Federica Zanotti Martina Trentini Elena Tiengo Ilaria Zanolla Elham Pishavar Elisa Soliani Marco Scatto Paolo Gargiulo Ylenia Zambito Stefano De Luca Letizia Ferroni Barbara Zavan 《International journal of molecular sciences》2022,23(15)
Regenerative medicine is the branch of medicine that effectively uses stem cell therapy and tissue engineering strategies to guide the healing or replacement of damaged tissues or organs. A crucial element is undoubtedly the biomaterial that guides biological events to restore tissue continuity. The polymers, natural or synthetic, find wide application thanks to their great adaptability. In fact, they can be used as principal components, coatings or vehicles to functionalize several biomaterials. There are many leading centers for the research and development of biomaterials in Italy. The aim of this review is to provide an overview of the current state of the art on polymer research for regenerative medicine purposes. The last five years of scientific production of the main Italian research centers has been screened to analyze the current advancement in tissue engineering in order to highlight inputs for the development of novel biomaterials and strategies. 相似文献
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453.
Barbara Ballarin Maria Cristina Cassani Daniele Nanni Chiara Parise Davide Barreca Giorgio Carraro Alberto Riminucci Ilaria Bergenti Vittorio Morandi Andrea Migliori Elisa Boanini 《Ceramics International》2019,45(1):449-456
Magnetic Fe3O4 (magnetite) nanoparticles are synthesized via a chemical precipitation route in different alkaline environments (NH3 or NaOH) and subsequently functionalized with a (propynylcarbamate)triethoxysilane moiety, with the aim of promoting the nucleation and subsequent stabilization of gold nanoparticles. The propynylcarbamate group is able to capture the gold precursor (HAuCl4), spontaneously reduce it, and stabilize the resulting Au nanoaggregates. The obtained results show that though the dimensions of the starting magnetite substrate depend on the base used in the preparation, they remain unaltered upon the subsequent modification. Conversely, the average Au nanoparticle dimensions can be conveniently tailored as a function of the base used in Fe3O4 preparation and the presence/absence of the organic functionalization. The smallest dimensions (15?nm) are obtained for AuNP supported on propynylcarbamate-functionalized Fe3O4 prepared in the presence of ammonia. Magnetization measurements highlight that all the Au/Fe3O4 nanocomposites display a superparamagnetic behavior and those obtained using ammonia showed consistently smaller Hc and Mr values (av. values of 7.4?Oe and 0.8?emu/g) than those prepared with sodium hydroxide (av. values of 28?Oe and 2.8?emu/g). 相似文献
454.
Valentina Ceccarelli Ilaria Barchetta Flavia Agata Cimini Laura Bertoccini Caterina Chiappetta Danila Capoccia Raffaella Carletti Claudio Di Cristofano Gianfranco Silecchia Mario Fontana Frida Leonetti Andrea Lenzi Marco Giorgio Baroni Eugenio Barone Maria Gisella Cavallo 《International journal of molecular sciences》2020,21(23)
Biliverdin reductase A (BVR-A) is an enzyme involved in the regulation of insulin signalling. Knockout (KO) mice for hepatic BVR-A, on a high-fat diet, develop more severe glucose impairment and hepato-steatosis than the wild type, whereas loss of adipocyte BVR-A is associated with increased visceral adipose tissue (VAT) inflammation and adipocyte size. However, BVR-A expression in human VAT has not been investigated. We evaluated BVR-A mRNA expression levels by real-time PCR in the intra-operative omental biopsy of 38 obese subjects and investigated the association with metabolic impairment, VAT dysfunction, and biopsy-proven non-alcoholic fatty liver disease (NAFLD). Individuals with lower VAT BVR-A mRNA levels had significantly greater VAT IL-8 and Caspase 3 expression than those with higher BVR-A. Lower VAT BVR-A mRNA levels were associated with an increased adipocytes’ size. An association between lower VAT BVR-A expression and higher plasma gamma-glutamyl transpeptidase was also observed. Reduced VAT BVR-A was associated with NAFLD with an odds ratio of 1.38 (95% confidence interval: 1.02–1.9; χ2 test) and with AUROC = 0.89 (p = 0.002, 95% CI = 0.76–1.0). In conclusion, reduced BVR-A expression in omental adipose tissue is associated with VAT dysfunction and NAFLD, suggesting a possible involvement of BVR-A in the regulation of VAT homeostasis in presence of obesity. 相似文献
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456.
Angela Serena Maione Ilaria Stadiotti Chiara Assunta Pilato Gianluca Lorenzo Perrucci Valentina Saverio Valentina Catto Giulia Vettor Michela Casella Anna Guarino Gianluca Polvani Giulio Pompilio Elena Sommariva 《International journal of molecular sciences》2021,22(5)
Arrhythmogenic Cardiomyopathy (ACM) is characterized by the replacement of the myocardium with fibrotic or fibro-fatty tissue and inflammatory infiltrates in the heart. To date, while ACM adipogenesis is a well-investigated differentiation program, ACM-related fibrosis remains a scientific gap of knowledge. In this study, we analyze the fibrotic process occurring during ACM pathogenesis focusing on the role of cardiac mesenchymal stromal cells (C-MSC) as a source of myofibroblasts. We performed the ex vivo studies on plasma and right ventricular endomyocardial bioptic samples collected from ACM patients and healthy control donors (HC). In vitro studies were performed on C-MSC isolated from endomyocardial biopsies of both groups. Our results revealed that circulating TGF-β1 levels are significantly higher in the ACM cohort than in HC. Accordingly, fibrotic markers are increased in ACM patient-derived cardiac biopsies compared to HC ones. This difference is not evident in isolated C-MSC. Nevertheless, ACM C-MSC are more responsive than HC ones to TGF-β1 treatment, in terms of pro-fibrotic differentiation and higher activation of the SMAD2/3 signaling pathway. These results provide the novel evidence that C-MSC are a source of myofibroblasts and participate in ACM fibrotic remodeling, being highly responsive to ACM-characteristic excess TGF-β1. 相似文献
457.
Ilaria Catusi Maria Teresa Bonati Ester Mainini Silvia Russo Eleonora Orlandini Lidia Larizza Maria Paola Recalcati 《International journal of molecular sciences》2020,21(22)
Maternal uniparental disomy of chromosome 7 is present in 5–10% of patients with Silver-Russell syndrome (SRS), and duplication of 7p including GRB10 (Growth Factor Receptor-Bound Protein 10), an imprinted gene that affects pre-and postnatal growth retardation, has been associated with the SRS phenotype. Here, we report on a 17 year old girl referred to array-CGH analysis for short stature, psychomotor delay, and relative macrocephaly. Array-CGH analysis showed two copy number variants (CNVs): a ~12.7 Mb gain in 7p13-p11.2, involving GRB10 and an ~9 Mb loss in 7q11.21-q11.23. FISH experiments performed on the proband’s mother showed a chromosome 7 pericentric inversion that might have mediated the complex rearrangement harbored by the daughter. Indeed, we found that segmental duplications, of which chromosome 7 is highly enriched, mapped at the breakpoints of both the mother’s inversion and the daughter’s CNVs. We postulate that pairing of highly homologous sequences might have perturbed the correct meiotic chromosome segregation, leading to unbalanced outcomes and acting as the putative meiotic mechanism that was causative of the proband’s rearrangement. Comparison of the girl’s phenotype to those of patients with similar CNVs supports the presence of 7p in a locus associated with features of SRS syndrome. 相似文献
458.
Blendi Ura Fulvio Celsi Luisa Zupin Giorgio Arrigoni Ilaria Battisti Bartolomea Gaita Domenico Leonardo Grasso Eva Orzan Raffaella Sagredini Egidio Barbi Sergio Crovella 《International journal of molecular sciences》2020,21(23)
Recurrent acute otitis media (RAOM) in children is clinically defined as the occurrence of at least three episodes of acute otitis media over a course of 6 months. A further common pathological condition of interest in the context of pediatric otolaryngology is adenotonsillar hypertrophy (ATH), a common cause of obstructive sleep apnea syndrome. Aimed at unraveling the differential modulation of proteins in the two pathologies and at understanding the possible pathways involved in their onset, we analyzed the proteomic profile of the adenoids from 14 RAOM and ATH patients by using two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS). The 2-DE coupled with MS allowed us to identify 23 spots with significant (p-value < 0.05) changes in protein amount, recognizing proteins involved in neutrophil degranulation and glycolysis pathways. 相似文献
459.
460.
Ilaria Di Marco Pisciottano Gustavo Damiano Mita 《Food Additives and Contaminants: Part B: Surveillance Communications》2020,13(2):139-147
ABSTRACT An analytical method is applied to simultaneously determine bisphenol A, 4-octylphenol, 4-tert-octylphenol, 4-nonylphenol and tert-nonylphenol in fish muscle. The method consisted of a cleanup on molecularly imprinted polymers cartridges (MIPs) followed by liquid chromatography coupled to a tandem mass spectrometer. The method is rapid, specific, reliable and very sensitive, allowing for quantification down to 0.5 ng/g for all studied compounds. After in-house validation, the method was employed to monitor the concentration levels of BPA and four target alkylphenols in 44 marine fish, collected from third countries in the frame of official control activities. The results showed that 27 samples (61.4%) were contaminated by at least one target compound. Bisphenol A was determined in 11 samples in the range 0.6–7.1 ng/g, 4-tert-octylphenol in 8 samples (0.5–1.6 ng/g) and tert-nonylphenol in 14 samples (0.8–8.9 ng/g). 4-Octylphenol and 4-nonylphenol were not detected at all. 相似文献