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Samuel Swearson Aseel O. Rataan Steven Eliason Brad A. Amendt Yousef Zakharia Aliasger K. Salem Thai Ho Youcef M. Rustum 《International journal of molecular sciences》2022,23(10)
This study was carried out to quantitate the expression levels of microRNA-17, -19a, -34a, -155, and -210 (miRs) expressed in nine clear cell renal cell carcinoma (ccRCC) and one chromophobe renal cell carcinoma cell line with and without sarcomatoid differentiation, and in six primary kidney tumors with matching normal kidney tissues. The data in the five non-sarcomatoid ccRCC cell lines—RC2, CAKI-1, 786-0, RCC4, and RCC4/VHL—and in the four ccRCC with sarcomatoid differentiation—RCJ41T1, RCJ41T2, RCJ41M, and UOK-127—indicated that miR-17 and -19a were expressed at lower levels relative to miR-34a, -155, and -210. Compared with RPTEC normal epithelial cells, miR-34a, miR-155, and miR-210 were expressed at higher levels, independent of the sarcomatoid differentiation status and hypoxia-inducible factors 1α and 2α (HIFs) isoform expression. In the one chromophobe renal cell carcinoma cell line, namely, UOK-276 with sarcomatoid differentiation, and expressing tumor suppressor gene TP53, miR-34a, which is a tumor suppressor gene, was expressed at higher levels than miR-210, -155, -17, and -19a. The pilot results generated in six tumor biopsies with matching normal kidney tissues indicated that while the expression of miR-17 and -19a were similar to the normal tissue expression profile, miR-210, -155, -and 34a were expressed at a higher level. To confirm that differences in the expression levels of the five miRs in the six tumor biopsies were statistically significant, the acquisition of a larger sample size is required. Data previously generated in ccRCC cell lines demonstrating that miR-210, miR-155, and HIFs are druggable targets using a defined dose and schedule of selenium-containing molecules support the concept that simultaneous and concurrent downregulation of miR-210, miR-155, and HIFs, which regulate target genes associated with increased tumor angiogenesis and drug resistance, may offer the potential for the development of a novel mechanism-based strategy for the treatment of patients with advanced ccRCC. 相似文献
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近年来,分布式工作流系统已经成为计算机方面的研究热点。工作流管理系统能够在生产设计过程中提高效率、降低成本、提高竞争力。随着网络技术和软件技术的发展,工作流系统已经得到了广泛的应用。通过介绍工作流管理系统的基本概念和结构,提出了一种基于J2EE的工作流管理系统的设计方案,使用shark开源工作流引擎,采用分布式策略将工作流系统功能模块化。通过对总体过程进行描述,各个模块间的相互配合工作,实现了B/S结构的工作流管理系统并应用于飞行器设计系统中。 相似文献
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一、辽宁省农村水电发展现状
1.水能资源概况
辽宁省农村水电资源主要分布在东部的鸭绿江水系、辽河水系的浑河和太子河等,另有西部的大凌河和青龙河等。根据2003年全国水力资源普查结果表明,全省河流水能资源理论蕴藏量为202万千瓦(单站500千瓦装机以上)。 相似文献
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Within the field of Information Systems, a good proportion of research is concerned with the work organisation and this has,
to some extent, restricted the kind of application areas given consideration. Yet, it is clear that information and communication
technology deployments beyond the work organisation are acquiring increased importance in our lives. With this in mind, we
offer a field study of the appropriation of an online play space known as Habbo Hotel. Habbo Hotel, as a site of media convergence,
incorporates social networking and digital gaming functionality. Our research highlights the ethical problems such a dual
classification of technology may bring. We focus upon a particular set of activities undertaken within and facilitated by
the space—scamming. Scammers dupe members with respect to their ‘Furni’, virtual objects that have online and offline economic
value. Through our analysis we show that sometimes, online activities are bracketed off from those defined as offline and
that this can be related to how the technology is classified by members—as a social networking site and/or a digital game.
In turn, this may affect members’ beliefs about rights and wrongs. We conclude that given increasing media convergence, the
way forward is to continue the project of educating people regarding the difficulties of determining rights and wrongs, and
how rights and wrongs may be acted out with respect to new technologies of play online and offline.
Marie Griffiths moved from the IT industry into academia and is now based at the University of Salford as an EPSRC Academic Fellow. She has, and continues to research gender and ICTs. Recently she has embarked upon the study “Cybercitizens and their Virtual Pursuits” to understand the consequence of growing up and living in a technologically saturated environment. Her work has been published in journals such as Gender, Work and Organization, the European Journal of Information Systems and Information Communication and Society. Ben Light is Professor of Technology and Society at the University of Salford. His research concerns the appropriation of configurable technologies within work, organisations and society. This has led him to explore the use of large-scale enterprise resource planning packages, call centre technologies, social networking sites and digital games. He has published in journals such as Communications of the ACM, Information Systems Journal, New Technology, Work and Employment, the European Journal of Information Systems and the Journal of Information Technology. 相似文献
Ben LightEmail: |
Marie Griffiths moved from the IT industry into academia and is now based at the University of Salford as an EPSRC Academic Fellow. She has, and continues to research gender and ICTs. Recently she has embarked upon the study “Cybercitizens and their Virtual Pursuits” to understand the consequence of growing up and living in a technologically saturated environment. Her work has been published in journals such as Gender, Work and Organization, the European Journal of Information Systems and Information Communication and Society. Ben Light is Professor of Technology and Society at the University of Salford. His research concerns the appropriation of configurable technologies within work, organisations and society. This has led him to explore the use of large-scale enterprise resource planning packages, call centre technologies, social networking sites and digital games. He has published in journals such as Communications of the ACM, Information Systems Journal, New Technology, Work and Employment, the European Journal of Information Systems and the Journal of Information Technology. 相似文献
27.
Mike Tien-Chien Lee Yu-Chin Hsu Ben Chen Masahiro Fujita 《Design Automation for Embedded Systems》1997,2(3-4):319-338
ATM switch, the core technology of an ATM networking system, is one of the major products in Fujitsu telecommunication business. However, current gate–level design methodology can no longer satisfy its stringent time–to–market requirement. It becomes necessary to exploit high–level methodology to specify and synthesize the design at an abstraction level higher than logic gates. This paper presents our prototyping experience on domain–specific high–level modeling and synthesis for Fujitsu ATM switch design. We propose a high–level design methodology using VHDL, where ATM switch architectural features are considered during behavior modeling, and a high–level synthesis compiler, MEBS, is prototyped to synthesize the behavior model down to a gate–level implementation. Since the specific ATM switch architecture is incorporated into both modeling and synthesis phases, a high–quality design is efficiently derived. The synthesis results shows that given the design constraints, the proposed high–level design methodology can produce a gate–level implementation by MEBS with about 15 percent area reduction in shorter design cycle when compared with manual design. 相似文献
28.
针尖增强拉曼光谱(TERS)技术由于其超高的空间分辨与灵敏的化学识别能力,在纳米尺度的结构表征和物理化学性质的分析中发挥着重要作用。本文首先回顾了高分辨TERS技术的近期发展与应用,并对高分辨成像的潜在物理机理进行了简要概述,接着介绍一种由超高分辨TERS成像衍生出来的新的分子化学结构解析方法―扫描拉曼埃分辨显微术(SRP),最后对SRP技术的进一步发展进行了展望。 相似文献
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Ben Shneiderman Catherine Plaisant Rodrigo Botafogo Don Hopkins William Weiland 《New Review of Hypermedia and Multimedia》2013,19(2):101-117
Since browsing hypertext can present a formidable cognitive challenge, user interface design plays a major role in determining acceptability. In the Unix workstation version of Hyperties, a research-oriented prototype, we focussed on design features that facilitate browsing. We first give a general overview of Hyperties and its markup language. Customizable documents can be generated by the conditional text feature that enables dynamic and selective display of text and graphics. In addition we present: — an innovative solution to link identification: pop-out graphical buttons of arbitrary shape. — application of pie menus to permit low cognitive load actions that reduce the distraction of common actions, such as page turning or window selection. — multiple window selection strategies that reduce clutter and housekeeping effort. We preferred piles-of-tiles, in which standard-sized windows were arranged in a consistent pattern on the display and actions could be done rapidly, allowing users to concentrate on the contents. 相似文献