Assessment of sun protection for children's summer 2005 clothing collection

Overexposure to solar ultraviolet radiation (UVR) in childhoodis considered to be a critical factor for developing skin cancerin later life. Clothing may offer a simple and effective meansof protection against overexposure to the sun, but its use hasoften been underrated in public opinion. The Health ProtectionAgency, in close collaboration with a number of UK retailers,conducted a study to evaluate the UVR protection characteristicsof the summer 2005 collection of children's clothing for outdooractivity. The current paper presents a summary of the assessmentand the effects of stretching and wetting on the UltravioletProtection Factor (UPF) rating of children's clothing. The resultsdemonstrate the need for better public guidance in sun protectionof children and more comprehensive evaluation procedures forsun protection provided by clothing.     

Assessment of dietary exposure to annatto (E160b), nitrites (E249-250), sulphites (E220-228) and tartaric acid (E334) in the French population: the second French total diet study

The results of the assessment of the dietary exposure to annatto, nitrites, tartaric acid and sulphites within the framework of the second French total diet study (TDS) are reported. These 4 additives were selected from the Bemrah et al. study [Bemrah N, Leblanc JC, Volatier JL. 2008. Assessment of dietary exposure in the French population to 13 selected food colours, preservatives, antioxidants, stabilizers, emulsifiers and sweeteners. Food Addit Contam B. 1(1):2-14] on 13 food additives which identified a possible health risk for annatto, sulphites and nitrites and a lack of data for tartaric acid. Among the composite samples selected for the whole TDS, 524 were analysed for additives (a sample was analysed for a given additive when it was identified as a major contributor for this additive only): 130 for tartaric acid, 135 for nitrites, 59 for annatto and 200 for sulphites. Estimated concentrations (minimum lower bound to maximum upper bound) vary nationally from 0 to 9 mg/kg for annatto, 0 to 420 mg/kg for tartaric acid, 0 to 108 mg/kg for sulphites and 0 to 3.4 mg/kg for nitrites. Based on the analytical results, the dietary exposure was calculated for adults and children, separately, using lower bound and upper bound assumptions. The European ADIs for these 4 additives were not exceeded except for the dietary exposure for sulphites among 2.9% of the adult population, where the major contributors were alcoholic drinks and especially wine under both hypotheses (lower and upper bound).     

High efficiency multichannel collimator for structural studies of liquids and low-Z materials at high pressures and temperatures

A high efficiency multichannel collimator (MCC) device has been developed at the high pressure beamline ID27 of the European Synchrotron Radiation Facility to drastically reduce the x-ray background from the sample environment in the Paris-Edinburgh press. The main technical difficulty, which resides in the minimum slits size achievable using the classical mono-bloc design, has been resolved using an original concept based on a set of independent slits. Then, a very small slit size of 50 μm was manufactured resulting in a great improvement of the signal to background ratio. In addition, the transfer function of the MCC has been measured using the x-ray diffusion signal of a metal doped glass and efficiently applied to correct the raw data. The potential of this new device is illustrated in two challenging examples: iron-sulfur liquid structures and C(60) polymerization process at high pressure and high temperature.     

A new empirical model for stormwater TSS event mean concentrations (EMCs)

An empirical model for TSS event mean concentrations in storm weather discharges has been derived from the analysis of data sets collected in two experimental catchments (Chassieu, separate system and Ecully, combined system) in Lyon, France. Preliminary tests have shown that the values of TSS EMCs were linked to the variable X =TP ×ADWP (TP rainfall depth, ADWP antecedent dry weather period) with two distinct behaviours under and above a threshold value of X named λ: EMCs are increasing if X < λ and are decreasing if X > λ. An empirical equation is proposed for both behaviours. A specific calibration method is used to calibrate λ while the 4 other parameters of the model are calibrated by means of the Levenberg-Marquardt algorithm. The calibration results obtained with 8 events in both sites indicate that the model calibration is satisfactory: Nash Sutcliffe coefficients are all above 0.7. Monte Carlo simulations indicate a low variability of the model parameters for both sites. The model verification with 5 events in Chassieu shows maximum levels of uncertainty of approximately 20%, equivalent to levels of uncertainty observed in the calibration phase.     

Limits of the quasi-induced exposure method when compared with the standard case-control design. Application to the estimation of risks associated with driving under the influence of cannabis or alcohol

The disparities between the quasi-induced exposure (QIE) method and a standard case–control approach with crash responsibility as disease of interest are studied. The 10,748 drivers who had been given compulsory cannabis and alcohol tests subsequent to involvement in a fatal crash in France between 2001 and 2003 were used to compare the two approaches. Odds ratios were assessed using conditional and unconditional logistic regressions. While both approaches found that drivers under the influence of alcohol or cannabis increased the risk of causing a fatal crash, the two approaches are not equivalent. They differ mainly with regards to the driver sample selected. The QIE method results in splitting the overall road safety issue into two sub-studies: a matched case–control study dealing with two-vehicle crashes and a case–control study dealing with single-vehicle crashes but with a specific control group. Using a specific generic term such as “QIE method” should not hide the real underlying epidemiological design. On the contrary, the standard case–control approach studies drivers involved in all type of crashes whatever the distribution of the responsibility in each crash. This method also known as “responsibility analysis” is the most relevant for assessing the overall road safety implications of a driver characteristic.     

A very promising new glucolipidic surfactant: Lipowheat

Lipowheat is an entirely biodegradable 100% natural active ingredient, extracted from non-transgenic wheat. Thanks to its very interesting properties, it can integrate the composition of most cosmetic and pharmaceutical products. The aim of this work was first to realize a large range of stable simple or multiple emulsions, in order to determine and evaluate the ability of a new glucolipidic surfactant Lipowheat to form and stabilize emulsions. The rheological properties of these emulsions were tested during a 30-day storage period at three different storage conditions (cold, room temperature and at 40 degrees C). In addition to dynamic and static rheological tests, droplet size distribution of the cream was also determined. Furthermore, a stable simple emulsion was selected to realize percutaneous absorption and evaluate the properties of Lipowheat.     

The effects of disc degeneration and muscle dysfunction on cervical spine stability from a biomechanical study

Disc degeneration and muscle dysfunction are common spinal degenerations in the elderly. This in vitro study was carried out to investigate the effects of these two degenerative changes on spinal stability. The stability of nine porcine cervical spines (C2-T1) with mechanically simulated cervical muscles (sternocleidomastoid (SCM), splenius capitis (SPL), semispinalis capitis (SSC)) was tested before and after experiment-induced disc degeneration. The patterns of muscle recruitments included: no muscle recruitment, normal recruitment of SCM/SPL/SSC, and SCM/SPL/SSC muscle dysfunctions. The neutral zone (NZ) and the range of motion (ROM) in the sagittal plane were measured to determine spinal stability. The results showed that the NZ and the ROM of a degenerative spine were larger than those of an intact spine under no muscle recruitment, but not under muscle recruitments. For both intact and degenerative spines, the NZ and the ROM were greatest under no muscle recruitment, followed by SSC dysfunction, SCM dysfunction, and SPL dysfunction, and smallest under normal muscle recruitment. In conclusion, muscle recruitments stabilize both intact and degenerative cervical spines, while dysfunctional muscles do not maintain stability efficiently as normal muscles do. Thus, spinal stability is more significantly affected by muscle dysfunction than by disc degeneration. Muscle training is suggested for the elderly with spinal degeneration to improve stability.     

Assessment of dietary exposure of nitrate and nitrite in France.

The aim of this study was to assess the dietary exposure of nitrate and nitrite in France. A total of 13, 657 concentration levels of nitrate and nitrite measured in food, representing 138 and 109 food items, respectively, and coming from French monitoring programmes between 2000 and 2006, were used. Depending on the non-detected and non-quantified analysis treatment, lower and upper concentration mean estimates were calculated for each food item. These were combined with consumption data derived from 1474 adults and 1018 children from the French national individual consumption survey (INCA1), conducted in 1999 and based on a 7-day food record diary. A total of 18% of spinaches, 6% of salads, 10% of cheeses, 8% of meat products and 6% of industrial meat products exceeded the European nitrate maximum level or maximum residual level. A total of 0.4% of industrial meat products and 0.2% of meat products exceeded their European nitrite maximum level or maximum residual level. Nitrate dietary exposure averaged 40% of the acceptable daily intake (ADI; 3.7 mg kg(-1) body weight day(-1)) for adults and 51 - 54% of the ADI for children with the major contributors being, for adults and children, respectively, vegetables (24 and 27% of ADI), potatoes (5 and 11% of ADI), and water (5 and 5% of ADI). The individual nitrate dietary intake of 1.4% (confidence interval (CI(95th)) [0.8; 2.0]) to 1.5% (CI(95th) [0.9; 2.1]) of adults and 7.9% (CI(95th) [6.2; 9.6]) to 8.4% (CI(95th) [6.7; 10.1]) of children were higher than the ADI. Nitrite dietary exposure averaged 33-67% of the ADI (0.06 mg kg(-1) body weight day(-1)) for adults and 67-133% of the ADI for children, with contributions of additive food vectors at 33% of ADI for adults and 50-67% of ADI for children. The individual nitrite dietary intake of 0.7% (CI(95th) [0.3; 1.1]) to 16.4% (CI(95th) [14.5; 18.3]) of adults and 10.5% (CI(95th) [8.6; 12.4]) to 66.2% (CI(95th) [63.3; 69.1]) of children were higher than the ADI.