二高炉4号热风炉烘炉实践

介绍了二高炉4号热风炉烘炉的特点、前期准备工作、具体操作过程中的注意事项及烘炉后的相关作业。此次生产实践对今后类似情况的热风炉烘炉具有参考价值。     

永久式防倒灌隔水采油工艺在长庆油田的应用

长庆油田存在严重的套管腐蚀损坏,采取的主要治理措施是隔水采油工艺技术。原有隔水采油工艺存在隔采周期短、检泵时水层倒灌污染油层、多次隔采后坐封难度大等问题,为此,试验应用了永久式防倒灌隔水采油工艺。现场试验、应用表明,该工艺具有隔采成功率高、隔采周期长等优点,能有效防止检泵时上部水层倒灌污染油层,具有很好的应用价值和推广前景。     

The effect of growth hormone replacement on cortisol metabolism and glucocorticoid sensitivity in hypopituitary adults

OBJECTIVE: Growth hormone (GH) replacement therapy in hypopituitary adults is associated with sodium and water retention. The underlying mechanisms are incompletely understood and a possible contribution of altered cortisol metabolism or action has not been evaluated. We have investigated the effect of GH replacement therapy on cortisol metabolism, cortisol binding globulin and in-vitro glucocorticoid sensitivity in a group of adult hypopituitary patients. DESIGN AND PATIENTS: We studied 19 adult hypopituitary patients (18 adult onset, M:F, 6:13), who were receiving conventional hydrocortisone (16 patients), thyroxine (14 patients), triiodothyronine (1 patient), sex steroid (9 patients), human chorionic gonadotrophin (1 patient) or desmopressin (6 patients) replacement during a 6-month, double blind controlled trial of GH therapy (active:placebo, 8:11) followed by a 6-month open phase of GH (mean dose: 0.2 IU/kg/week, range 0.051-0.27) and after a 6-week washout phase following discontinuation of GH therapy. MEASUREMENTS: Twenty-four-hour urine free cortisol, cortisol metabolites (CoM), ratio 11-hydroxy/11-oxo CoM (F/E) and ratio 5 alpha/beta tetrahydrocortisol were measured at 6 months, 12 months and after the 6 week washout phase. Serum cortisol binding globulin was measured basally, at 6 months, 12 months and after washout. Glucocorticoid sensitivity was determined in lymphocyte preparations from 8 patients, during GH therapy and after washout, using an in-vitro technique dependent on dexamethasone suppression of phytohaemagglutinin-stimulated thymidine incorporation into DNA. Plasma renin activity and aldosterone were measured after 6-12 months GH therapy and after washout. RESULTS: After 6 months of GH, in patients on hydrocortisone (n = 9), there were significant decreases in CoM (mean decrement 21%, P < 0.01), F/E (mean decreased from 1.27 to 1.0, P = 0.04; reference range 0.33-1.29) and 5 alpha/5 beta tetrahydrocortisol (mean decreased from 0.67 to 0.48, P = 0.01) and a subsequent increase after washout. Patients not on hydrocortisone (n = 2) demonstrated a normal basal F/E falling by 25% on GH therapy but no change in CoM. During 12 months of GH therapy, patients on hydrocortisone (n = 7) demonstrated a further trend to decrement in CoM (P = 0.09) which reversed after washout (P = 0.04). Urine free cortisol tended to fall during GH therapy and increased significantly following washout after 12 months treatment (P < 0.02). Serum cortisol binding globulin decreased by 20% (P < 0.05) during 12 months GH treatment but remained within the reference range. In-vitro studies demonstrated a trend to reduced glucocorticoid sensitivity on GH therapy; the maximum inhibition of phytohaemagglutinin by dexamethasone tended to be less on GH therapy (P = 0.052) and was also lower than in 29 normal volunteers (P < 0.05). There were no significant changes in plasma renin but there was a small increment in aldosterone in recumbent patients (P = 0.04) during the open phase of GH therapy in the placebo arm. CONCLUSIONS: GH therapy in hypopituitary adults is associated with an apparent reduction in availability of administered hydrocortisone as measured by urine cortisol metabolites and urine free cortisol. This effect is unlikely to be clinically significant except possibly in ACTH deficient subjects on suboptimal hydrocortisone replacement. The changes in F/E suggest that GH may directly or indirectly modulate the activity of 11 beta-hydroxysteroid dehydrogenase. The apparent decrease in glucocorticoid sensitivity during GH therapy, demonstrated in vitro, merits further investigation.     

AutoCAD在更改连铸设备布局设计中的应用

将AutoCAD应用到更改连铸设备布局设计中，可使更改过程一目了然。     

N- and O-glycosylation muteins of recombinant human erythropoietin secreted from BHK-21 cells

Single-site glycomuteins of recombinant human erythropoietin (rhuEpo) were constructed and transiently and stably expressed in BHK-21 cells. The transient expression levels varied among muteins, being highest for mutein rhuEpoGln24 followed by wild-type rhuEpo (rhuEpowt). All other glycomuteins, including rhuEpoGln38, rhuEpoGln83, rhuEpoThr126, and rhuEpoGly126, were secreted at lower levels than rhuEpowt. Muteins expressed in stable cell lines showed similar differences in expression levels. Also each mutein could be affinity-purified from culture supernatants, and was biologically active in vivo. Based on secretion rates from BHK-21 cells, the most potent erythropoietin was rhuEpoGln24. This mutein is also considered to have biologic activities that are superior to rhuEpowt.     

使用Python开发跨平台的单词助记程序

介绍使用Python语言开发跨平台的单词助记程序原型的方法,包括安装配置Python环境、单词数据词典文件的格式、程序的主要代码和运行过程。     

热卷箱是提高热连轧线竞争能力的最佳选择

介绍了热卷箱技术的发展及在我国的应用情况。结合“双工位无芯卷取”热卷箱技术在宝钢集团梅山钢铁公司1422mm热轧厂的成功应用，重点介绍了该技术的特点及在解决热轧板带中节能减排、减少氧化铁皮、避免甩尾、稳定精轧轧制及开发高附加值产品等方面的优势；认为其是提高热轧板厂竞争力的最佳选择。     

改性膨润土的吸附性能研究

用NaOH改性、微波改性、焙烧改性膨润土,以亚甲基蓝溶液模拟污染物对原土和改性膨润土的吸附性能进行考查.实验结果表明,膨润土经改性后,其吸附性能与原土相比有明显改善.经NaOH改性、微波改性、400℃下焙烧2 h改性后的膨润土对25 mg/L的亚甲基蓝溶液的脱除率分别为75.64％、74.36％、68.17％.     

基于AI加速模块的换流站控制保护二次回路预警系统

当前的故障录波器终端受制于硬件平台,对换流站控制保护二次回路暂稳态大量数据的处理能力有限,单纯依靠软件算法提高分析准确率的空间有限,目前识别准确率无法达到可靠应用的要求.只有发生故障时,运维人员才会调取相应波形进行查看,对于大量监测波形,无法依靠人工识别出电气参量的微小变化,降低了运检人员的工作效率.本文提出一种基于AI边缘计算的监测数据实时分析预警系统,在故障录波器装置端配置AI加速模块,搭建换流站控制保护多源数据模型,采用统计分析和波形分析的多维数据处理算法,对换流站控制保护二次回路数据进行实时在线计算,以及时发现控制保护二次回路隐蔽性缺陷并预警.