KRT4 suppresses oral squamous cell carcinoma development by reducing ATG4B-mediated autophagy

Head and neck squamous cell carcinoma is the sixth most common tumor worldwide, and half of head and neck squamous cell carcinoma patients are with oral squamous cell carcinoma (OSCC). 300,000 new cases of OSCC were reported annually. Even with multi-modality treatment, the prognosis of OSCC remains unsatisfactory. Thus, it is urgent to discover novel therapeutic targets for OSCC. Some microarray studies have revealed that Keratin 4 (KRT4) is downregulated in OSCC, whereas its role in OSCC development remains unknown. The present study revealed that KRT4 suppressed OSCC progression by inducing cell apoptosis and inhibiting cell invasion. In addition, KRT4 over-expression inhibited autophagy by blocking the interaction of autophagy-related 4B cysteine peptidase (ATG4B) and microtubule-associated protein 1A/1B light chain 3 (LC3) to regulate apoptosis and invasion of OSCC. In conclusion, KRT4 played an important role in OSCC development through regulating ATG4B-mediated autophagy and may be a novel therapeutic drug target of OSCC.     

Biomedical overview of melanin. 2. Updating molecular modeling,synthesis mechanism,and supramolecular properties regarding melanoma therapy

Melanins represent one of the most ancient and important group of natural macromolecular pigments. They have multiple biological roles in almost all organisms across the Phyla, examples being photoprotection, anti-oxidative action, radical scavenger activity, and heavy metal removal. From the biomedical point of view, melanocytes are involved in the origin of melanoma tumors, and the main therapeutic advances for their treatment have been revised in Part 1 of this review. The chemical structure of eumelanin is a biological concern of great importance, and therefore, exploring theoretical molecular models and synthesis mechanisms will be here described, as well as molecular orbital features and supramolecular organization, which are responsible for the key properties that make these biological pigments so important, and so fascinating. Ultimately, this updated overview is devoted to describe present structural models and physico-chemical characteristics of eumelanin, in order to explain and utilize melanin properties on which new photothermal and ultrasonic protocols for melanoma treatment can be devised and applied.

     

复合量程微加速度计动态特性分析

介绍一种复合量程微加速度计,并分析其加速度计的阻尼比、幅频特性和相频特性,计算出其工作的频响范围。对加速度计的动态特性进行测试,对比分析理论计算结果与测试结果,验证该复合量程加速度计满足设计要求,可以有效地工作在4个量程范围内。     

PROBABILISTIC MODELS FOR MONITORING AND FAULT DIAGNOSIS: APPLICATION AND EVALUATION IN A MOBILE ROBOT

This paper presents a general approach for building a robust and efficient supervision system for fault detection and recovery. The approach uses a set of monitors that obtain information about the system state and, instead of detecting fault states directly, detects significant differences between perceived and expected states. To deal with uncertainty in the knowledge about the system state and the result of some actions, it uses a POMDP model to decide when it is worthwhile to take recovery actions. We present the general approach and show its application with an indoor mobile robot by reporting and evaluating comparative results for different solutions.     

基于Verilog HDL设计实现的乘法器性能研究

本文在设计实现乘法器时,采用了4-2和5-2混合压缩器对部分积进行压缩,减少了乘法器的延时和资源占用率;经xilinx ISE和Quartus Ⅱ两种集成开发环境下的综合仿真测试,与用Verilog HDL语言实现的两位阵列乘法器和传统的Booth编码乘法器进行了性能比较,得出用这种混合压缩的器乘法器要比传统的4-2压缩器构成的乘法器速度提高了10%,硬件资源占用减少了1%.     

导航接收机上位机软件的设计与开发

本文以GPS导航接收机的研制为背景,在VC MFC AppWizard环境中针对上位机软件进行了详细的说明,其中包括上位机与下位机之间的数据通信、数据的实时显示、实时绘图、线程的使用、用户界面的设计等等.重点介绍了软件在开发过程中的要点和难点.其后,通过与下位机连接,运行GPS导航接收机程序验证了上位机软件开发的正确性、实用性、直观性.     

一些稿件存在问题分析

对一些稿件存在的问题进行了分析 ,这些问题主要是 :①不符合办刊宗旨 ;②内容浅显空洞 ;③无创新性 ;④缺乏科学性 ;⑤无实用价值 ;⑥逻辑性差 ;⑦文不对题 ;⑧过分保密 ;⑨其它等。就如何解决这些问题 ,提高投稿命中率提出了 4点建议 :①平时要多看国内外有关科技期刊 ,及时掌握国内或国外某个学科或某项研究的发展动态 ,了解哪些是研究前沿 ,找准自己的切入点 ;②要多参与科研项目 ,多做实验 ,努力提高自己的实验技能和专业知识水平 ;③要勤于笔耕 ,多写多练 ,努力提高自己的写作水平 ;④要按照欲投期刊的格式与要求进行写作。