Comprehensive characterization of the functional activities of pressurized liquid and ultrasound-assisted extracts from Chlorella vulgaris

Chlorella vulgaris has been referred as a potential source of bioactive compounds (carotenoids and fatty acids). In this work, the ability of an environmentally friendly extraction technique such as Pressurized Liquid Extraction (PLE) and a traditional extraction technique such as Ultrasound-Assisted Extraction (UAE) to obtain functional compounds from C. vulgaris, at analytical scale, has been demonstrated. Seeked bioactivities were antioxidant and antimicrobial, for their interest in the food industry. Therefore, a methodology including analytical extraction, in-vitro assays and chemical characterization via HPLC-DAD and GC–MS has been used to determine the interest of Chlorella as a source of functional food ingredients. Results demonstrated that PLE provide higher yields than UAE while similar bioactivities were obtained. Important concentration of carotenoids (lutein, neoxanthin, β-carotene, etc.), chlorophylls, sterols, phytols, and fatty acids (among others) have been found in Chlorella extracts that could be correlated to the observed biological activity.     

Crossing Paths in Human Renal Cell Carcinoma (hRCC)

Historically, cell-signaling pathways have been studied as the compilation of isolated elements into a unique cascade that transmits extracellular stimuli to the tumor cell nucleus. Today, growing evidence supports the fact that intracellular drivers of tumor progression do not flow in a single linear pathway, but disseminate into multiple intracellular pathways. An improved understanding of the complexity of cancer depends on the elucidation of the underlying regulatory networks at the cellular and intercellular levels and in their temporal dimension. The high complexity of the intracellular cascades causes the complete inhibition of the growth of one tumor cell to be very unlikely, except in cases in which the so-called “oncogene addiction” is known to be a clear trigger for tumor catastrophe, such as in the case of gastrointestinal stromal tumors or chronic myeloid leukemia. In other words, the separation and isolation of the driver from the passengers is required to improve accuracy in cancer treatment. This review will summarize the signaling pathway crossroads that govern renal cell carcinoma proliferation and the emerging understanding of how these pathways facilitate tumor escape. We outline the available evidence supporting the putative links between different signaling pathways and how they may influence tumor proliferation, differentiation, apoptosis, angiogenesis, metabolism and invasiveness. The conclusion is that tumor cells may generate their own crossroads/crosstalk among signaling pathways, thereby reducing their dependence on stimulation of their physiologic pathways.     

Rejoinder to “Multiple versions of the h-index: cautionary use for formal academic purposes”

Scientometrics - In a Letter to the Editor, the authors of this paper show, to highlight the practical risks of using the h-index, how academics’ data and bibliometric information can be...     

EETP-MAC: energy efficient traffic prioritization for medium access control in wireless body area networks

Wireless body area network (WBAN) has witnessed significant attentions in the healthcare domain using biomedical sensor-based monitoring of heterogeneous nature of vital signs of a patient’s body. The design of frequency band, MAC superframe structure, and slots allocation to the heterogeneous nature of the patient’s packets have become the challenging problems in WBAN due to the diverse QoS requirements. In this context, this paper proposes an Energy Efficient Traffic Prioritization for Medium Access Control (EETP-MAC) protocol, which provides sufficient slots with higher bandwidth and guard bands to avoid channels interference causing longer delay. Specifically, the design of EETP-MAC is broadly divided in to four folds. Firstly, patient data traffic prioritization is presented with broad categorization including Non-Constrained Data (NCD), Delay-Constrained Data (DCD), Reliability-Constrained Data (RCD) and Critical Data (CD). Secondly, a modified superframe structure design is proposed for effectively handling the traffic prioritization. Thirdly, threshold based slot allocation technique is developed to reduce contention by effectively quantifying criticality on patient data. Forth, an energy efficient frame design is presented focusing on beacon interval, superframe duration, and packet size and inactive period. Simulations are performed to comparatively evaluate the performance of the proposed EETP-MAC with the state-of-the-art MAC protocols. The comparative evaluation attests the benefit of EETP-MAC in terms of efficient slot allocation resulting in lower delay and energy consumption.

     

A simple approach to solving the kinematics of the 4-UPS/PS (3R1T) parallel manipulator

Journal of Mechanical Science and Technology - This work reports on the position, velocity and acceleration analyses of a four-degrees-of-freedom parallel manipulator, 4-DoF-PM for brevity, which...     

Ocular movements under taskload manipulations: Influence of geometry on saccades in air traffic control simulated tasks

Traffic geometry is a factor that contributes to cognitive complexity in air traffic control. In conflict‐detection tasks, geometry can affect the attentional effort necessary to correctly perceive and interpret the situation; online measures of situational workload are therefore highly desirable. In this study, we explored whether saccadic movements vary with changes in geometry. We created simple scenarios with two aircraft and simulated a conflict detection task. Independent variables were the conflict angle and the distance to convergence point. We hypothesized lower saccadic peak velocity (and longer duration) for increasing complexity, that is, for increasing conflict angles and for different distances to convergence point. Response times varied accordingly with task complexity. Concerning saccades, there was a decrease of peak velocity (and a related increase of duration) for increased geometry complexity for large saccades (>15°). The data therefore suggest that geometry is able to influence “reaching” saccades and not “fixation” saccades. © 2011 Wiley Periodicals, Inc.     

Comparison of Peleg and Azuara et al. models in the modeling mass transfer during pile salting of goat sheets

Application of the Peleg and Azuara et al. models for describing mass transfer during pile salting of goat sheets using different mixtures of NaCl, KCl, CaCl₂ and MgCl₂ was investigated The high coefficient of determination (R² > 0.97 and R² > 0.95 for Peleg and Azuara et al. models, respectively) and the modulus of mean relative errors (MRE < 10% for both models) indicated the acceptability of both Peleg and Azuara et al. models for predicting both moisture loss and salt uptake. The equilibrium moisture and salt contents were estimated using Peleg rate constants and Azuara et al. model parameters. Equilibrium moisture (x_w) and salt contents (x_s) varied from 0.522 to 0.860 g water/g db and from 0.311 to 0.352 g NaCl/g db respectively. Multiple comparison of means showed that x_w and x_s predicted by the Peleg model were lower than those estimated by the Azuara et al. model. The values differed by 1.86–13.6% for x_w and by 1.13–10.57% for x_s.     

Occupational therapy for people with physical disability using interactive environments

Universal Access in the Information Society - This paper preconizes the use of interactive environments as an accessible and inexpensive solution that allows supporting the recovery process of...