Invited review: Inbreeding in the genomics era: Inbreeding,inbreeding depression,and management of genomic variability

Traditionally, pedigree-based relationship coefficients have been used to manage the inbreeding and degree of inbreeding depression that exists within a population. The widespread incorporation of genomic information in dairy cattle genetic evaluations allows for the opportunity to develop and implement methods to manage populations at the genomic level. As a result, the realized proportion of the genome that 2 individuals share can be more accurately estimated instead of using pedigree information to estimate the expected proportion of shared alleles. Furthermore, genomic information allows genome-wide relationship or inbreeding estimates to be augmented to characterize relationships for specific regions of the genome. Region-specific stretches can be used to more effectively manage areas of low genetic diversity or areas that, when homozygous, result in reduced performance across economically important traits. The use of region-specific metrics should allow breeders to more precisely manage the trade-off between the genetic value of the progeny and undesirable side effects associated with inbreeding. Methods tailored toward more effectively identifying regions affected by inbreeding and their associated use to manage the genome at the herd level, however, still need to be developed. We have reviewed topics related to inbreeding, measures of relatedness, genetic diversity and methods to manage populations at the genomic level, and we discuss future challenges related to managing populations through implementing genomic methods at the herd and population levels.     

A Review of “Marketing Today’s Academic Library: A Bold New Approach to Communicating with Students”

ABSTRACT

This paper contends that the potential of Usenet as an information tool is outstanding, but that librarians have been slow to realize this promise. By examining Usenet discussions, the paper looks at the issues involved in using Usenet, and discusses the notion that real information can only come from professionals. It concludes that Usenet is a valuable tool that needs to be developed, especially when determining what sources of information could best assist patrons.     

An Error Rate Comparison of Classification Methods with Continuous Explanatory Variables

In the fields of statistics and computer science a wide variety of methodologies exist for solving the traditional classification problem. This study will compare the error rates for various methods under a variety of conditions when the explanatory variables are continuous. The methods under considerations are neural networks, classical discriminant analysis, and two different approaches to decision trees. Training and testing sets are utilized to estimate the error rates of these methods for different numbers of sample sizes, number of explanatory variables, and the number of classes in the dependent variable. These error rates will be used to draw generalized conclusions about the relative efficiencies of the techniques.     

Fairness or stereotypes? Young children's priorities when evaluating group exclusion and inclusion.

Seventy-two children (35 4?-year-olds and 37 5?-year-olds), nearly evenly divided by gender, from European American (71%), Asian American (17%), and African American (12%) middle-class backgrounds, were individually interviewed about straightforward exclusion and inclusion for two gender-stereotypic peer-group contexts: activities (doll and truck play) and role-play (teacher and firefighter). All children evaluated straightforward exclusion based on gender (e.g., girls excluding a boy from doll play) as wrong and used moral reasons. Preliminary inclusion decisions in the activity contexts (choosing a boy or a girl to join the group) were based on stereotypic expectations, particularly for younger children. Given the opportunity to weigh alternative considerations, however, all children gave priority to fairness over stereotypic expectations in both multifaceted inclusion peer-group contexts. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Differences in traffic judgements between young and old adult pedestrians

Older pedestrians have been shown to be over-involved in casualty crashes, compared to younger pedestrians, in recent reports. This study set out to investigate whether older pedestrians' road crossing behaviour might render them more vulnerable to crashes because of declines in their physical, sensory, perceptual or cognitive abilities. An initial ‘blackspot’ accident analysis highlighted the types of crashes in which older (and younger) adult pedestrians were involved and likely crossing actions. Road crossing behaviour was then systematically measured from unobtrusive video recordings of individual road crossings for a sample of younger and older pedestrians at several urban locations. On two-way undivided roads, older pedestrians crossed more frequently when there was closer moving traffic and generally adopted less safe road crossing strategies than their younger counterparts. On one-way divided roads, their crossing behaviour was considerably more safe and similar to that of younger pedestrians. The findings suggest that age-related perceptual and cognitive deficits may play a substantial role in many of the crashes involving older pedestrians.     

When the face reveals what words do not: Facial expressions of emotion, smiling, and the willingness to disclose childhood sexual abuse.

For survivors of childhood sexual abuse (CSA), verbal disclosure is often complex and painful. The authors examined the voluntary disclosure-nondisclosure of CSA in relation to nonverbal expressions of emotion in the face. Consistent with hypotheses derived from recent theorizing about the moral nature of emotion, CSA survivors who did not voluntarily disclose CSA showed greater facial expressions of shame, whereas CSA survivors who voluntarily disclosed CSA expressed greater disgust. Expressions of disgust also signaled sexual abuse accompanied by violence. Consistent with recent theorizing about smiling behavior, CSA nondisclosers made more polite smiles, whereas nonabused participants expressed greater genuine positive emotion. Discussion addressed the implications of these findings for the study of disclosure of traumatic events, facial expression, and the links between morality and emotion. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Short communication: Implementation of a breeding value for heat tolerance in Australian dairy cattle

Excessive ambient temperature and humidity can impair milk production and fertility of dairy cows. Selection for heat-tolerant animals is one possible option to mitigate the effects of heat stress. To enable selection for this trait, we describe the development of a heat tolerance breeding value for Australian dairy cattle. We estimated the direct genomic values of decline in milk, fat, and protein yield per unit increase of temperature-humidity index (THI) using 46,726 single nucleotide polymorphisms and a reference population of 2,236 sires and 11,853 cows for Holsteins and 506 sires and 4,268 cows for Jerseys. This new direct genomic value is the Australian genomic breeding value for heat tolerance (HT ABVg). The components of the HT ABVg are the decline in milk, fat, and protein per unit increase in THI when THI increases above the threshold of 60. These components are weighted by their respective economic values, assumed to be equivalent to the weights applied to milk, fat, and protein yield in the Australian selection indices. Within each breed, the HT ABVg is then standardized to have a mean of 100 and standard deviation (SD) of 5, which is consistent with the presentation of breeding values for many other traits in Australia. The HT ABVg ranged from ?4 to +3 SD in Holsteins and ?3 to +4 SD in Jerseys. The mean reliabilities of HT ABVg among validation sires, calculated from the prediction error variance and additive genetic variance, were 38% in both breeds. The range in ABVg and their reliability suggests that HT can be improved using genomic selection. There has been a deterioration in the genetic trend of HT, and to moderate the decline it is suggested that the HT ABVg should be included in a multitrait economic index with other traits that contribute to farm profit.     

爱立信IMS weShare分享每一天(系列之一)消费者行为分析:多媒体丰富通信最为期待

如果电信行业密切关注并充分利用已知的用户行为模式,同时采取措施来丰富语音通信并增进语音与数据业务之间的互动性,电信行业就可以在更大程度上改善个人之间的通信.当计划并开发更加丰富的通信业务(如爱立信IMS weShare)时,易用性是电信行业需要考量的一项关键因素.