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11.
Lima A.M.N. Deep G.S. Neto J.S.R. Freire R.C.S. Lobo P.C. 《IEEE transactions on instrumentation and measurement》1994,43(2):133-138
An identification procedure to estimate the parameters of a thermoresistive solar radiation sensor is presented. The proposed technique employs only electrical excitation for the sensor. The estimation algorithm is recursive and is applied to the sensor model derived from the thermodynamic equilibrium differential equations. The simulation and the experimental results demonstrate the validity of the proposed approach 相似文献
12.
Morphological analysis of poly(o-methoxyaniline) thin-films deposited by spin coating technique 总被引:1,自引:0,他引:1
John Paul H. Lima Adnei M. de Andrade 《Journal of Materials Science: Materials in Electronics》2006,17(8):593-596
Morphological study of conducting polymer thin films obtained by spin coating is reported. Poly(o-methoxyaniline) films were deposited onto glass substrates and analyzed by profilometry and atomic force microscopy (AFM).
It is shown that final thickness is correlated by a power law with spin speed with a solution concentration varying coefficient
and that surface roughness decreases with increasing spin speed. 相似文献
13.
Rui A. S. Lapa José L. F. C. Lima 《Journal of Automated Methods and Management in Chemistry》1991,13(3):119-122
The construction of a microcomputer-controlled electrode switch for
use in potentiometric determinations is described. This can be coupled to most of the analytical equipment usually found in laboratories, to enable a setting up of automatic systems capable of performing sequential determinations with several ion-selective
electrodes. The assessment of its analytical usage and behaviour are discussed. 相似文献
14.
15.
The authors demonstrate the optical generation of extremely narrow linewidth millimetre-wave signals between 40 and 60 GHz using a single-chip semiconductor laser. A dual-mode long-cavity multisection DFB semiconductor laser is driven at a subharmonic of the free-running-mode beat signal frequency to produce phase-locked millimetre waves with a 3 dB linewidth of less than 10 Hz and a 3 dB locking range of ~500 MHz 相似文献
16.
R. Bonadiman M. D. Lima M. J. de Andrade C. P. Bergmann 《Journal of Materials Science》2006,41(22):7288-7295
In this work, the Catalytic Chemical Vapor Deposition (CCVD) technique was used to synthesize carbon nanotubes (CNT). Natural gas (NG) was employed as a carbon source for the growing of CNT, while magnesium oxide was used as a catalyst support for the nanotubes synthesis. Two systems were utilized. The Fe–Mo/MgO system was obtained by the impregnation technique through the dispersion of iron oxide, which is the catalyst, over magnesia (with molybdenum additions). This system was tested intending to optimize the parameters for the production of single-walled carbon nanotubes (SWCNT). Moreover, Mg1−x
Fe
x
MoO4, which was prepared by the combustion synthesis method, was tested to produce multi-walled carbon nanotubes (MWCNT). The Fe-Mo/MgO tests were carried out under H2/GN and Ar/GN atmospheres at 950 °C, whereas the Mg1−x
Fe
x
MoO4 was submitted to 1,000 °C under H2/GN atmosphere. The Fe–Mo/MgO catalyst produced better results regarding number of CNT and their diameters under Ar/NG atmospheres than under H2/NG atmospheres. The system Mg1−x
Fe
x
MoO4 produced MWCNT according to the expectations. 相似文献
17.
18.
T De Brito CR Carneiro MC Nakhle DM Lima CP Abrantes-Lemos M Sandoval AM Silva 《Canadian Metallurgical Quarterly》1998,6(4):368-376
Gene therapy has the potential to provide cancer treatments based on novel mechanisms of action with potentially low toxicities. This therapy may provide more effective control of loco-regional recurrence in diseases such as non-small cell lung cancer (NSCLC), as well as systemic control of micrometastases. Despite current limitations, retroviral and adenoviral vectors can in certain circumstances provide an effective means of delivering therapeutic genes to tumour cells. Although multiple genes are involved in the process of carcinogenesis, mutations of the p53 gene are the most frequent abnormality identified in human tumours. Pre-clinical studies both in vitro and in vivo have shown that restoration of p53 function can induce apoptosis in cancer cells. Phase I clinical trials now show that p53 gene replacement therapy is feasible and safe using both retroviral and adenoviral vectors, and that it induces tumour regression in patients with advanced NSCLC and recurrent head and neck cancer. Other pre-clinical studies indicate that gene therapy may have useful synergy with cytotoxic and radiation therapy. This paper describes the different gene therapy strategies under investigation and the pre-clinical data that provides a rationale for the gene replacement approach, reviews clinical trial data and presents novel ideas for improving current vectors and gene delivery to tumours. 相似文献
19.
Marta Teixeira Pinto Ana Sofia Ribeiro Inês Conde Rita Carvalho Joana Paredes 《International journal of molecular sciences》2021,22(1)
The high plasticity of cancer stem-like cells (CSCs) allows them to differentiate and proliferate, specifically when xenotransplanted subcutaneously into immunocompromised mice. CSCs are highly tumorigenic, even when inoculated in small numbers. Thus, in vivo limiting dilution assays (LDA) in mice are the current gold standard method to evaluate CSC enrichment and activity. The chick embryo chorioallantoic membrane (CAM) is a low cost, naturally immune-incompetent and reproducible model widely used to evaluate the spontaneous growth of human tumor cells. Here, we established a CAM-LDA assay able to rapidly reproduce tumor specificities—in particular, the ability of the small population of CSCs to form tumors. We used a panel of organotropic metastatic breast cancer cells, which show an enrichment in a stem cell gene signature, enhanced CD44+/CD24−/low cell surface expression and increased mammosphere-forming efficiency (MFE). The size of CAM-xenografted tumors correlate with the number of inoculated cancer cells, following mice xenograft growth pattern. CAM and mice tumors are histologically comparable, displaying both breast CSC markers CD44 and CD49f. Therefore, we propose a new tool for studying CSC prevalence and function—the chick CAM-LDA—a model with easy handling, accessibility, rapid growth and the absence of ethical and regulatory constraints. 相似文献
20.
Sofia Cotton Dylan Ferreira Janine Soares Andreia Peixoto Marta Relvas-Santos Rita Azevedo Paulina Piairo Lorena Diguez Carlos Palmeira Luís Lima Andr M. N. Silva Lúcio Lara Santos Jos Alexandre Ferreira 《International journal of molecular sciences》2021,22(4)
Esophageal cancer (EC) is a life-threatening disease, demanding the discovery of new biomarkers and molecular targets for precision oncology. Aberrantly glycosylated proteins hold tremendous potential towards this objective. In the current study, a series of esophageal squamous cell carcinomas (ESCC) and EC-derived circulating tumor cells (CTCs) were screened by immunoassays for the sialyl-Tn (STn) antigen, a glycan rarely expressed in healthy tissues and widely observed in aggressive gastrointestinal cancers. An ESCC cell model was glycoengineered to express STn and characterized in relation to cell proliferation and invasion in vitro. STn was found to be widely present in ESCC (70% of tumors) and in CTCs in 20% of patients, being associated with general recurrence and reduced survival. Furthermore, STn expression in ESCC cells increased invasion in vitro, while reducing cancer cells proliferation. In parallel, an ESCC mass spectrometry-based proteomics dataset, obtained from the PRIDE database, was comprehensively interrogated for abnormally glycosylated proteins. Data integration with the Target Score, an algorithm developed in-house, pinpointed the glucose transporter type 1 (GLUT1) as a biomarker of poor prognosis. GLUT1-STn glycoproteoforms were latter identified in tumor tissues in patients facing worst prognosis. Furthermore, healthy human tissues analysis suggested that STn glycosylation provided cancer specificity to GLUT1. In conclusion, STn is a biomarker of worst prognosis in EC and GLUT1-STn glycoforms may be used to increase its specificity on the stratification and targeting of aggressive ESCC forms. 相似文献