Nicholas Hobbs (1915–1983).

Presents an obituary for Nicholas Hobbs. Just at the end of his stellar career of public service through psychology, Nick Hobbs received very appropriate honors showing that psychologists and many others knew what a precious national resource his life had been. Only days before his death from cancer on January 23, 1983, he participated in the dedication of the Nicholas Hobbs Laboratory of Human Development of the Peabody College for Teachers of Vanderbilt University, part of the Kennedy Center for Research on Education and Human Development that he founded and directed at its beginning. Two years earlier, he had received two parallel American Psychological Association (APA) awards--one for Distinguished Contributions to Psychology in the Public Interest and another for Distinguished Professional Contributions "utilizing psychological knowledge in the public interest and social policy." As the citations and testimonials on these occasions variously noted, Nick gave creative, responsible, and effective service to the institutions that he helped administer, to the Southern region from which he sprang, to the APA, and to the profession of psychology, but above all to the nation's children and youth, especially those who grew up with disadvantage and difficulty. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Treatment approaches following foot and ankle injury

A complete and effective rehabilitation program begins with a thorough subjective and objective evaluation of the problem and injury presented. Biomechanical changes, whether they are anatomically induced or as a result of a form of compensation, must be identified and properly addressed. During the initial phase of rehabilitation, the issues of pain and swelling often must be resolved before full range of motion and return to normal strength can be achieved successfully during the more advanced stages. It is important to incorporate the entire lower quadrant in exercises that are designed to improve proprioception and function, using both in open and closed kinetic chain exercises. Finally, the demands to which the patient is returning to must be recognized to successfully complete the recovery phase.     

Handover signalling for microcellular environments

A new strategy for routing handover signalling in microcellular environments is proposed. Simulation results show that time delay for handover packets travelling across the fixed network could be reduced by diverting the signalling through the air interface between the serving and the candidate base station (BS)     

Feedback Specificity, Learning Opportunities, and Learning.

Although increasing feedback specificity is generally beneficial for immediate performance, it can undermine certain aspects of the learning needed for later, more independent performance. The results of the present transfer experiment demonstrate that the effects of increasing feedback specificity on learning depended on what was to be learned, and these effects were partially mediated through the opportunities to learn how to respond to different task conditions during practice. More specific feedback was beneficial for learning how to respond to good performance and detrimental for learning how to respond to poor performance. The former relationship was partially mediated by feedback specificity's effect on learning opportunities during practice. The results have implications for designing feedback interventions and training to maximize the learning of various aspects of a task. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychology and war-avoidance: On Blight's blighted view.

Criticizes J. G. Blight's (see record 1987-16803-001) use of references, his identification with the policy of deterrence, his dismissal of approaches to reversing the nuclear arms race, and his discussion of a sociobiology of war. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Flavor Fade in Peanuts During Short-term Storage

ABSTRACT: Flavor characteristics of roasted peanuts over short-term storage were explored through sensory and chemical analyses. The volatiles from freshly roasted peanuts were evaluated over short-time (21 d) storage using gas chromatography, chemosensory techniques, and a sensory panel to quantify and identify pyrazines and hexanal over a 21-d storage period. A significant decrease ( P < 0.05) was noted in 2,3-diethylpyrazine, 2-methoxypyrazine, 2,3-dimethylpyrazine, 2-ethyl-3-methylpyrazine, and 2,3,5-trimethylpyrazine concentrations over a 21-d period. No significant difference ( P > 0.05) was noted in the 2-methylpyrazine and 2-ethylpyrazine concentrations. The hexanal concentration significantly increased ( P < 0.05) over the 21-d period. The peroxide values and sensory analysis agreed with these results. A significant increase ( P < 0.05) in peroxide value was seen at days 14 and 21, and a significant decrease ( P < 0.05) in fresh roasted peanuty flavor from day 0 to 21 and significant increases ( P < 0.05) in painty, cardboardy, and bitter flavors from day 7 to 21 with the sensory analysis. The electronic nose successfully separated day 0 and 21 samples from day 7 and 14 samples, which were also separated but with some overlap.     

Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold‐Hopping Approach

Starting from suvorexant (trade name Belsomra), we successfully identified interesting templates leading to potent dual orexin receptor antagonists (DORAs) via a scaffold‐hopping approach. Structure–activity relationship optimization allowed us not only to improve the antagonistic potency on both orexin 1 and orexin 2 receptors (Ox1 and Ox2, respectively), but also to increase metabolic stability in human liver microsomes (HLM), decrease time‐dependent inhibition of cytochrome P450 (CYP) 3A4, and decrease P‐glycoprotein (Pgp)‐mediated efflux. Compound 80 c [{(1S,6R)‐3‐(6,7‐difluoroquinoxalin‐2‐yl)‐3,8‐diazabicyclo[4.2.0]octan‐8‐yl}(4‐methyl‐[1,1′‐biphenyl]‐2‐yl)methanone] is a potent and selective DORA that inhibits the stimulating effects of orexin peptides OXA and OXB at both Ox1 and Ox2. In calcium‐release assays, 80 c was found to exhibit an insurmountable antagonistic profile at both Ox1 and Ox2, while displaying a sleep‐promoting effect in rat and dog models, similar to that of the benchmark compound suvorexant.     

Review of Treating the juvenile offender.

Reviews the book, Treating the juvenile offender edited by Robert D. Hoge, Nancy G. Guerra, and Paul Boxer (see record 2008-02979-000). This book rejuvenates interest in treatment for juvenile offenders, outlining the important advances that have been made, key challenges that remain, and useful principles for effectively meeting these challenges. Key themes that are emphasised include the importance of evidence-based approaches, interventions that are sensitive to the ecological systems within which youth are embedded, and rehabilitative strategies that are closely informed by research on youths’ risks, needs, and strengths. This book does not deliver a quick manual on how to deliver a particular program, but instead carefully models how to think about and approach treatment. While the book remains accessible to beginners, it is written in a manner which will be thought-provoking and informative even for experts. Furthermore, it is likely to have the positive effect of leaving readers with a desire to learn and do more to improve current practices. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

How can we best use landmarks to support older people in navigation?

Although landmarks are an integral part of navigation, they have rarely been used explicitly within electronic pedestrian navigation aids. We describe a two-part study into the use of landmarks in such aids, using a set of field experiments. The first part investigated whether such devices can be effective for older adults (over 60 years old), who might particularly benefit from them due to declines in sensory, cognitive and motor abilities. The second part compared the effectiveness of different methods of presenting landmark information. We show that a pedestrian navigation aid based around landmarks is particularly useful for older people and demonstrate that text, speech and photographs are all effective ways of presenting landmark information, although speech on its own has some drawbacks. We found that different people prefer information to be presented in different modalities, indicating a need for personalisation, although multi-modality may also help to address this issue.