Value to smokers of improved cessation products: evidence from a willingness-to-pay survey.

The present study demonstrated the use of willingness to pay to value hypothetical new smoking cessation products. Data came from a baseline survey of participants in a clinical trial of medications for smoking cessation (N=356) conducted in New Haven, Connecticut. We analyzed individual willingness to pay for a hypothetical tobacco cessation treatment that is (a) more effective than those currently available and then (b) more effective and attenuates the weight gain often associated with smoking cessation. A majority of the respondents (n=280; 84%) were willing to pay for the more effective treatment, and, of those, 175 (63%) were willing to pay more if the increased effectiveness was accompanied by attenuation of the weight gain associated with smoking cessation. The present study suggests the validity of using willingness-to-pay surveys in assessing the value of new smoking cessation products and products with multifaceted improvements. From these data, we calculated estimates of the value of a quit. For the population studied, this survey suggests a substantial market for more effective smoking cessation treatments.     

Academic perspectives on the principles for training in consulting psychology.

This article represents a conceptual analysis of the proposed training principles for consulting psychology (CP) as approved and forwarded by the Society of Consulting Psychology (R. L. Lowman et al; see record 2003-04049-003). Strengths and weaknesses of the document are identified and briefly analyzed from the perspective of academic programs and faculty. The major topics addressed include the role of the scientist-practitioner model, research and evaluation skills, ethical matters, training level, multidisciplinary opportunities, and the focus on competencies. Persistent questions about what CP is and perhaps about what it should be arise very naturally from a careful consideration of training practices. Persistent questions and issues also arise regarding the basic operational definitions of CP as they relate to current practices. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

An investigation of the validity of the Quality of Well-Being scale with pediatric oncology patients.

Investigated the usefulness of the Quality of Well-Being scale (QWB) in a sample of pediatric cancer patients. The parents of 30 children (aged 4–18 yrs) who were being treated for cancer were administered the QWB. Performance status ratings from the parents and physician, toxicity ratings, treatment information, and routine laboratory values were also collected. Correlational analyses indicated that QWB scores were significantly related to ratings of performance status and that children who had experienced more surgeries and hospitalizations were assessed as more impaired on the QWB. The child's age, toxicity of treatment experience to date, and laboratory values were not significantly related to QWB findings. The potential utility of the QWB as a component of quality of life assessment is discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Recovering recyclable materials from shredder residue

Each year, about 11 million tons of metals are recovered in the United States from about 10 million discarded automobiles. The recovered metals account for about 75 percent of the total weight of the discarded vehicles. The balance of the material, known as shredder residue, amounts to about three million tons annually and is currently landfilled. The residue contains a diversity of potentially recyclable materials, including polyurethane foams, iron oxides, and certain thermoplastics. This article discusses a process under development at Argonne National Laboratory to separate and recover the recyclable materials from this waste stream. The process consists essentially of two stages. First, a physical separation is used to recover the foams and the metal oxides, followed by a chemical process to extract certain thermoplastics. The status of the technology and the process economics are reviewed here.     

Behavioral and characterological attributional styles as predictors of depression and loneliness: Review, refinement, and test.

The literature on self-blame and depression reveals 2 interrelated problems. First, although R. Janoff-Bulman's (see record 1981-01320-001) conceptualizations of self-blame are clear, empirical operationalization is difficult and has resulted in approaches that do not capture the richness of the constructs. Second, past research has produced inconsistent findings. A comprehensive literature review revealed that the inconsistencies are related to the method of assessing attributions. A correlational study, with 2 samples of 680 and 321 undergraduates, designed to more accurately represent the self-blame conceptualization revealed that both behavioral and characterological self-blame contribute uniquely to depression and loneliness. Supplementary results regarding circumstantial attributions and regarding attributional styles for success were presented. Empirical issues regarding possible methodological refinements and effect size, as well as the value of categorical approaches to the study of attributional style were discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Application of an incremental method to the solution of general plane strain boundary value problems in finite elasticity—II: Computer program and numerical results

A computer program is described for the solution of a system of incremental, partial differential equations, in the case of incompressible materials. The numerical solution is based on the finite difference approximations. Corresponding incremental governing equations are formulated in part one of this paper.Further, a treatment of general meshes is proposed which gives an extension of the modes of application of the finite difference method. In this paper this method is applied to simply connected domains.Finally, some numerical results obtained from applications of the computer program are cited.     

Satisfaction with processes of collecting student opinions about instruction: The student perspective.

This study used a 2?×?2?×?2 factorial experiment to examine student satisfaction with eight processes of collecting student ratings of instruction by varying (a) method (group interviews vs. individual standardized rating forms), (b) timing (midterm vs. end of course), and (c) amount of instructor reaction to student ratings (restricted vs. extended). Consistent with predictions drawn from reactance and social comparison theories, students were more satisfied with interview methods at midterm followed by extended instructor reaction than with traditional approaches for collecting student opinions about instruction (i.e., standardized rating forms administered at the end of a course). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Analysis of the tensile behaviour of viscoelastically prestressed polymeric matrix composites

A novel composite material is reported, in which tension, applied to polymeric fibres, is released prior to moulding them into a matrix. Following matrix solidification, compressive stresses imparted by the viscoelastically strained fibres impede crack propagation. Previous Charpy impact studies had demonstrated that these viscoelastically prestressed composites could absorb typically 25–30% more energy than control (unstressed) counterparts and the current study focuses on their tensile behaviour as a function of fibre volume fraction, V_f. Tensile testing was performed on continuous unidirectional nylon 6,6 fibre–epoxy resin samples. Compared with control counterparts, the results showed that viscoelastic prestressing improved tensile properties, the effects being V_f-dependent. Increases in tensile strength, modulus and energy absorbed (to 0.25 strain) exceeded 15%, 30% and 40%, respectively, at an optimum V_f, this being 35–40%. Strain-to-failure was reduced by 10–20%, thereby lowering any improvement in tensile toughness (energy absorbed to fracture) to <10%. Mechanical properties of the fibres themselves were not significantly influenced by the treatment used for generating composite prestress, and we propose that the observed improvements to tensile properties may be attributed to: (i) direct contribution from compressive stress, (ii) attenuation of the dynamic overstress effect on fibre fracture and (iii) improved mechanical integrity through a more collective response from fibres to tensile loads.     

Library Screening by Means of Mass Spectrometry (MS) Binding Assays-Exemplarily Demonstrated for a Pseudostatic Library Addressing γ-Aminobutyric Acid (GABA) Transporter 1 (GAT1)

In the present study, the application of mass spectrometry (MS) binding assays as a tool for library screening is reported. For library generation, dynamic combinatorial chemistry (DCC) was used. These libraries can be screened by means of MS binding assays when appropriate measures are taken to render the libraries pseudostatic. That way, the efficiency of MS binding assays to determine ligand binding in compound screening with the ease of library generation by DCC is combined. The feasibility of this approach is shown for γ‐aminobutyric acid (GABA) transporter 1 (GAT1) as a target, representing the most important subtype of the GABA transporters. For the screening, hydrazone libraries were employed that were generated in the presence of the target by reacting various sets of aldehydes with a hydrazine derivative that is delineated from piperidine‐3‐carboxylic acid (nipecotic acid), a common fragment of known GAT1 inhibitors. To ensure that the library generated is pseudostatic, a large excess of the nipecotic acid derivative is employed. As the library is generated in a buffer system suitable for binding and the target is already present, the mixtures can be directly analyzed by MS binding assays—the process of library generation and screening thus becoming simple to perform. The binding affinities of the hits identified by deconvolution were confirmed in conventional competitive MS binding assays performed with single compounds obtained by separate synthesis. In this way, two nipecotic acid derivatives exhibiting a biaryl moiety, 1‐{2‐[2′‐(1,1’‐biphenyl‐2‐ylmethylidene)hydrazine]ethyl}piperidine‐3‐carboxylic acid and 1‐(2‐{2′‐[1‐(2‐thiophenylphenyl)methylidene]hydrazine}ethyl)piperidine‐3‐carboxylic acid, were found to be potent GAT1 ligands exhibiting pK_i values of 6.186±0.028 and 6.229±0.039, respectively. This method enables screening of libraries, whether generated by conventional chemistry or DCC, and is applicable to all kinds of targets including membrane‐bound targets such as G protein coupled receptors (GPCRs), ion channels and transporters. As such, this strategy displays high potential in the drug discovery process.     

Reducing sodium levels in frankfurters using naturally brewed soy sauce

Sodium chloride (NaCl; salt) serves important functions in processed meats, contributing to desirable quality and food safety characteristics; however, renewed interest exists in reducing sodium in the human diet despite sodium being a required component of the diet for physiological regulation. This study investigated consumer sensory and quality impacts from replacement of normally added NaCl (flake salt) with naturally brewed soy sauce (SS). Varying levels of SS were used with NaCl and/or potassium chloride (KCl) to comprise treatments (TRT) which investigated flake salt replacement (Phase I) and sodium reduction (Phases II and III). Phase I identified a 50% replacement of NaCl with SS as the baseline for subsequent phases. Phase II indicated that the inclusion of SS could allow for a 20% NaCl reduction without adverse effects on quality or sensory attributes. Phase III results demonstrated that it was feasible to reduce NaCl by 35% via the inclusion of KCl in SS containing frankfurters without major quality or sensory changes.