Accelerating Cyclic Update Algorithms for Parameter Estimation by Pattern Searches

A popular strategy for dealing with large parameter estimation problems is to split the problem into manageable subproblems and solve them cyclically one by one until convergence. A well-known drawback of this strategy is slow convergence in low noise conditions. We propose using so-called pattern searches which consist of an exploratory phase followed by a line search. During the exploratory phase, a search direction is determined by combining the individual updates of all subproblems. The approach can be used to speed up several well-known learning methods such as variational Bayesian learning (ensemble learning) and expectation-maximization algorithm with modest algorithmic modifications. Experimental results show that the proposed method is able to reduce the required convergence time by 60–85% in realistic variational Bayesian learning problems.     

Sol–gel based protective coatings for copper products

Corrosion, fouling, and wearing of metal surfaces are the most common problems faced in industry as well as in environmental use. In the recent study, sol–gel based protective coatings were developed and deposited on different copper substrates. Different chemical pretreatments were used to enhance the adhesion and spreadability of coatings on copper surfaces. Substantial improvement of the corrosion resistance of sol–gel coated copper surfaces was obtained by a salt spray test. In addition, the sol–gel coatings increased hydrophobic and easy-to-clean properties of the copper surface. Variation of the curing temperature of the coatings caused changes in the morphology, adhesion, and topography of the sol–gel coatings. On the basis of the important information obtained in this study, the protective properties of sol–gel coatings can be tailored for copper and copper alloy substrates.     

Selective Seasonal Fatty Acid Accumulation and Mobilization in the Wild Raccoon Dog (<Emphasis Type="Italic">Nyctereutes procyonoides</Emphasis>)

Previous studies on laboratory rodents, rabbits and humans have demonstrated that fatty acid (FA) mobilization from white adipose tissue (WAT) is selective and its efficiency is related to FA structure. Selective FA mobilization was also documented in a carnivore, the farmed raccoon dog (Nyctereutes procyonoides), fasted for 8 weeks. The present study explored whether similar selectivity of FA mobilization was manifested in wild mammals experiencing seasonal food scarcity and abundance. Fractional mobilization from and incorporation into WAT of a wide spectrum of FA were studied by gas–liquid chromatography from the subcutaneous WAT of free-ranging raccoon dogs with the same individuals sampled in consecutive seasons. The wintertime FA mobilization was selective and mostly confirmed the patterns of FA release in captivity. Mobilization correlated inversely with the FA chain length but increased with unsaturation and when the first double bond was located closer to the methyl end. 18–20C n-3 polyunsaturated FA (PUFA) and 14–17C monounsaturated FA (MUFA) were preferentially mobilized while 19–24C saturated FA and MUFA were preserved during wintering. The summertime FA incorporation correlated inversely with the chain length and increased with unsaturation and in MUFA and PUFA with double bonds closer to the methyl end. The principles of selective FA mobilization were valid in wild mammals. FA incorporation was also selective and reversed the wintertime losses of the preferably mobilized FA.     

Effects of High Temperature on the Pore Structure and Strength of Plain and Polypropylene Fiber Reinforced Cement Pastes

The effect of high temperature on the residual properties of plain and polypropylene fiber reinforced Portland cement paste was investigated. Plain Portland cement paste having water/cement ratio of 0.32 was exposed to the temperatures of 20, 50, 75, 100, 120, 150, 200, 300, 400, 440, 520, 600, 700, 800, and 1000°C. Paste with polypropylene fibers was exposed to the temperature of 20, 120, 150, 200, 300, 440, 520, and 700°C. Residual compressive and flexural strengths were measured and pore structure of the pastes was determined by mercury porosimetry. The total porosity of the pastes more than doubled when exposure temperature was increased from 20°C to 1000°C. The gradual heating coarsened the pore structure. The most notable coarsening of pore structure—together with strength loss—took place at exposure temperatures exceeding 600°C. At 600°C, the residual compressive capacity (f_c600°C/f_c20°C) was still over 50% of the original. Strength loss due to the increase of temperature was not linear. Polypropylene fibers produced a finer residual capillary pore structure, decreased compressive strengths, and improved residual flexural strengths at low temperatures. According to the tests, it seems that exposure temperatures from 50°C to 120°C can be as dangerous as exposure temperatures 400–500°C to the residual strength of cement paste produced by a low water cement ratio.     

Germline POT1 Deregulation Can Predispose to Myeloid Malignancies in Childhood

While the shelterin complex guards and coordinates the mechanism of telomere regulation, deregulation of this process is tightly linked to malignant transformation and cancer. Here, we present the novel finding of a germline stop-gain variant (p.Q199*) in the shelterin complex gene POT1, which was identified in a child with acute myeloid leukemia. We show that the cells overexpressing the mutated POT1 display increased DNA damage and chromosomal instabilities compared to the wildtype counterpart. Protein and mRNA expression analyses in the primary patient cells further confirm that, physiologically, the variant leads to a nonfunctional POT1 allele in the patient. Subsequent telomere length measurements in the primary cells carrying heterozygous POT1 p.Q199* as well as POT1 knockdown AML cells revealed telomeric elongation as the main functional effect. These results show a connection between POT1 p.Q199* and telomeric dysregulation and highlight POT1 germline deficiency as a predisposition to myeloid malignancies in childhood.     

Unified software development approach for the safety-critical ITER maintenance devices

The RH devices used for ITER divertor maintenance are movers or manipulators composed of electro-hydraulic and electrical actuators. Such devices are CMM, CTM and WHMAN to assist CMM and CTM. These devices execute complex and safety-critical operations while supporting ITER reactor elements weighting several tons. Despite the differences in the load capacity and functionality, the control system of these devices can be categorized as position servo control or force servo control. In this paper we propose the use of unified software development approach currently developed and demonstrated at the DTP2. This new approach takes into account the ITER RH requirements for all maintenance devices, not only the water-hydraulic maintenance devices. The need for extensive software verification and validation utilizing international standards for safety-critical systems is addressed. This applies both to control software architecture and user interface design. In principle, we propose that all ITER maintenance devices are developed and tested with the common software architecture and user interface. This makes it possible to reuse generic software modules that are well documented and tested, resulting decreased verification and validation period and development cost. Utilising this approach also improves reliability and safety of the maintenance operations.     

Enabling Remote Testing: Embedded Test Controller and Mixed-signal Test Architecture

Remote testing requires embedded test infrastructure, consisting of communication, test control and test access. This article presents an embedded test solution for a low-frequency audio board. Supporting analog testing, the solution consists of a measurement and calculation method for passive component characterization, analog test bus solution and an embedded test controller for controlling embedded tests and providing test stimuli. Moreover, the solution, which supports the presented test plan, was compared to a test plan supporting traditional testing. It was found that the embedded test solution provided a 29% test coverage of the audio board components and substituted flying probe testing included in the traditional test plan. Besides such benefits as improved fault diagnostics and lower manufacturing costs, the paper also discusses the drawbacks of the presented solution, including reduced measurement accuracy. This paper also presents a correction to a previously presented passive component measurement and calculation method.     

Huffman coding of DCT coefficients using dynamic codeword assignment and adaptive codebook selection

In many image sequence compression applications, Huffman coding is used to eliminate statistical redundancy resident in given data. The Huffman table is often pre-defined to reduce coding delay and table transmission overhead. Local symbol statistics, however, may be much different from the global ones manifested in the pre-defined table. In this paper, we propose three Huffman coding methods in which pre-defined codebooks are effectively manipulated according to local symbol statistics. The first proposed method dynamically modifies the symbol-codeword association without rebuilding the Huffman tree itself. The encoder and decoder maintain identical symbol-codeword association by performing the same modifications to the Huffman table, thus eliminating extra transmission overhead. The second method adaptively selects a codebook from a set of given ones, which produces the minimum number of bits. The transmission overhead in this method is the codebook selection information, which is observed to be negligible compared with the bit saving attained. Finally, we combine the two aforementioned methods to further improve compression efficiency. Experiments are carried out using five test image sequences to demonstrate the compression performance of the proposed methods.     

In Vitro Release Behavior of Toremifene Citrate from Sol-Gel Processed Sintered Silica Xerogels

Factors affecting the adsorption and desorption of toremifene citrate (TC) on sintered silica xerogels were investigated in vitro. TC was attached onto sol-gel processed sintered silica xerogel grains or disks by adsorption. The adsorption of TC on the surface of silica was pH dependent. The results support the conclusion that large pore size results in highest drug adsorption. Adsorption of TC was most effective in xerogels sintered at 700°C and containing the largest pores and lowest specific surface area of the silica xerogels studied in the adsorption tests. The release of TC from the xerogel matrix was linear with respect to the square root of time. The release of TC from the grains was very rapid for the first 5 hr, followed by a slower release. All drug was released from the grains, and 60% to 80% was released from the disks in 24 hr. All drug-silica xerogel formulations showed sustained in vitro release profiles.     

Methodology for modelling plug-in electric vehicles in the power system and cost estimates for a system with either smart or dumb electric vehicles

The article estimates the costs of plug-in electric vehicles (EVs) in a future power system as well as the benefits from smart charging and discharging EVs (smart EVs). To arrive in a good estimate, a generation planning model was used to create power plant portfolios, which were operated in a more detailed unit commitment and dispatch model. In both models the charging and discharging of EVs is optimised together with the rest of the power system. Neither the system cost nor the market price of electricity for EVs turned out to be high (36-263 €/vehicle/year in the analysed scenarios). Most of the benefits of smart EVs come from smart timing of charging although benefits are also accrued from provision of reserves and lower power plant portfolio cost. The benefits of smart EVs are 227 €/vehicle/year. This amount has to cover all expenses related to enabling smart EVs and need to be divided between different actors. Additional benefits could come from the avoidance of grid related costs of immediate charging, but these were not part of the analysis.