On the Development of Analogue Sampled-Data Signal Processing

This paper provides a historical perspective on thedevelopment of analogue sampled-data signal processing circuitsand systems. The evolution, role and current trends in the developmentof analogue sampled-data signal processing systems is surveyed.Firstly, the evolution of integrated circuit based techniques,culminating in the ubiquitous switched-capacitor technique istraced. Then the role that analogue sampled-data systems playwithin the context of a general information processing environmentis examined and the required characteristics are identified.Trends in silicon integrated circuit processing technology aresummarised and their impact on sampled analogue circuits areidentified. Finally, the application of analogue current-modetechniques, and in particular switched-currents, to overcomesome of the limitations of previous voltage based approaches,is discussed.     

Which differintegration? [fractional calculus]

Despite the great advances in the theory and applications of fractional calculus, some topics remain unclear, making a systematic use difficult. In this paper, the fractional differintegration definition problem is studied from a systems point of view. Both local (Grunwald-Letnikov) and global (convolutional) definitions are considered. It is shown that the Cauchy formulation should be adopted since it is coherent with usual practice in signal processing and control applications.     

Effect of milk fat and total solids concentration on the kinetics of moisture uptake by ready-to-eat breakfast cereal

Summary When immersed in milk, breakfast cereal easily take up moisture, lose their brittle texture and become soggy. Earlier comparative analysis of the moisture sorption by breakfast cereal immersed in water and milk indicated that milk solids might play an important role on the sorption kinetics. In this work, the moisture uptake by ready-to-eat corn breakfast cereal immersed in milk solutions, reconstituted from whole and skimmed milk powder, was measured under isothermal conditions at 5, 30 and 55 °C. Dilutions between 0.25 and 1.5 were tested, with the factor of dilution 1 corresponding to the standard recommended by the milk powder manufacturer. The Weibull probabilistic model adequately fitted the experimental data by appropriate choice of its variable parameters. The dependence of the model parameters on temperature and total solids concentration was assessed for both skimmed and whole milk. Fat was found to play a major role on the process mechanism, which was attributed to the deposition of a fat layer at the solid matrix surface, hindering water and solids uptake. Yet, for short times, moisture uptake proceeded at a similar rate both in skimmed and whole milk.     

3D Printing and Nanotechnology: A Multiscale Alliance in Personalized Medicine

3D printing and nanotechnology have been two important tools in the development of therapeutic approaches for personalized medicine. More recently, their alliance has been improved in an effort to build innovative, versatile, multifunctional, and/or smart medical and pharmaceutical products. Therefore, an extensive review about scientific studies that ally 3D printing and nanomaterials in the development of new approaches for pharmaceutical and medical applications for the treatment and prevention of diseases is presented here. The articles are classified into five categories according to their main application: Cell growth and tissue engineering, antimicrobial, drug delivery, stimulus-response, and theranostics. Semisolid extrusion, inorganic nanoparticles, and cell growth and tissue engineering are the most reported 3D printing technique, type of nanomaterial, and application, respectively. The increase in papers dedicated to these areas is also notable, especially in the 2019 and 2020, when semisolid extrusion became the most used technique, overcoming fused deposition modelling. In fact, this review highlights that the possibility of an alliance between 3D printing and nanotechnology for the production of multiscale materials is undoubtedly a great opportunity for knowledge and innovation in the pharmaceutical and medical area.     

Introducing the fractional-order Darwinian PSO

One of the most well-known bio-inspired algorithms used in optimization problems is the particle swarm optimization (PSO), which basically consists on a machine-learning technique loosely inspired by birds flocking in search of food. More specifically, it consists of a number of particles that collectively move on the search space in search of the global optimum. The Darwinian particle swarm optimization (DPSO) is an evolutionary algorithm that extends the PSO using natural selection, or survival of the fittest, to enhance the ability to escape from local optima. This paper firstly presents a survey on PSO algorithms mainly focusing on the DPSO. Afterward, a method for controlling the convergence rate of the DPSO using fractional calculus (FC) concepts is proposed. The fractional-order optimization algorithm, denoted as FO-DPSO, is tested using several well-known functions, and the relationship between the fractional-order velocity and the convergence of the algorithm is observed. Moreover, experimental results show that the FO-DPSO significantly outperforms the previously presented FO-PSO.     

Flexibility valuation in the Brazilian power system: A real options approach

This paper presents a valuation study of operational flexibility in the complex Brazilian Power System. Thermopower plants represent operational flexibility for the national system operator provided they can be dispatched in dry periods to supply part of the load when reservoir waters are too low. Deficit costs can be avoided as a result.

We have adopted a real options approach to calculate the fair value of a financial subsidy to be paid to thermal generators for their availability to the system. A financial subsidy is mandatory for their economic feasibility and, therefore, for increased thermopower capacity in the Brazilian Power System. This is why this policy is currently being studied by Brazil's federal government.

In order to illustrate our modeling we have run the model for the southeast subsystem. We found a flexibility value of US$4.52 billion, which represents US$497/MW per year. This means that a 100 MW thermopower plant should receive US$49,700 for each year of its economic lifetime as a fair premium incentive to investments.     

In vivo antitumoural activity and composition of an oil extract of Brazilian propolis

The present study aimed to evaluate in vivo and in vitro the antitumoural activity of a propolis extract obtained with edible vegetable oil and its fractions and also to investigate its chemical composition by LC–MS and LC–MS/MS. To evaluate the toxicological aspects related to the propolis extract treatment, hematological, biochemical, histopathological and morphological analyses of treated animals were performed. All propolis extracts showed an in vivo antitumour activity in the experimental model with a moderate toxicity effect at experimental exposure levels. The oil extract was as effective as the ethanolic extract at inhibiting tumour growth. In vitro assays showed that the whole oil extract produced better inhibition of tumour cells than its fractions. LC–MS and LC–MS/MS identified four phenolic acids and three flavonoids. The anticancer potential of the oil extract of propolis has been demonstrated and the edible vegetable oil was shown as an attractive alternative solvent to extract bioactive natural propolis components.     

Short communication: Principal components and factor analytic models for test-day milk yield in Brazilian Holstein cattle

A total of 46,089 individual monthly test-day (TD) milk yields (10 test-days), from 7,331 complete first lactations of Holstein cattle were analyzed. A standard multivariate analysis (MV), reduced rank analyses fitting the first 2, 3, and 4 genetic principal components (PC2, PC3, PC4), and analyses that fitted a factor analytic structure considering 2, 3, and 4 factors (FAS2, FAS3, FAS4), were carried out. The models included the random animal genetic effect and fixed effects of the contemporary groups (herd-year-month of test-day), age of cow (linear and quadratic effects), and days in milk (linear effect). The residual covariance matrix was assumed to have full rank. Moreover, 2 random regression models were applied. Variance components were estimated by restricted maximum likelihood method. The heritability estimates ranged from 0.11 to 0.24. The genetic correlation estimates between TD obtained with the PC2 model were higher than those obtained with the MV model, especially on adjacent test-days at the end of lactation close to unity. The results indicate that for the data considered in this study, only 2 principal components are required to summarize the bulk of genetic variation among the 10 traits.     

Bifidobacterium Bb-12 microencapsulated by spray drying with whey: Survival under simulated gastrointestinal conditions,tolerance to NaCl,and viability during storage

Bifidobacterium Bb-12 was microencapsulated by spray drying with whey. This present work investigated the survival of these microcapsules under simulated gastrointestinal conditions, as well as their tolerance to NaCl and their viability during storage. The results showed a small decrease in the viability of microencapsulated Bifidobacterium at low pH. In relation to the exposure of Bifidobacterium to bile, microencapsulation with whey did not protect the probiotic cells; however, the viability of the microcapsules remained >6 log cfu/g, even after 24 h of incubation at the highest bile concentration analyzed. No growth was noted with either the free cells or the microencapsulated cells on MRS-LP with NaCl. The viability of the microcapsules stored at 4 °C remained high and constant for 12 weeks. When the microcapsules were added to a dairy dessert, the probiotic count remained above 7 log cfu/g for 6 weeks. Therefore, whey is a promising encapsulating agent for Bifidobacterium Bb-12.     

Development of Active Films From Pectin and Fruit Extracts: Light Protection,Antioxidant Capacity,and Compounds Stability

Pectin films containing fruit extracts were developed and tested in relation to ultraviolet light transmission, phytochemical contents, and antioxidant capacity during 90 d shelf life storage. Aqueous and alcoholic extracts from 5 different fruits (acerola, cashew apple, papaya, pequi, and strawberry) were obtained. Because the alcoholic extracts from acerola, cashew apple, and strawberry presented the highest phytochemical content and antioxidant capacity, they were incorporated into pectin films individually or as a mixture. Incorporation of these extracts into pectin films provided antioxidant capacity while retaining the physical properties. The pectin films containing fruit extract acted as adequate light barrier and prevented photooxidation. Among the prepared films, the pectin film containing acerola extract afforded the highest antioxidant capacity, with a half‐life of 99 d. Overall, the results revealed that incorporation of fruit extracts into pectin films potentially produces antioxidant films and coatings for different food applications.