Reducing Playground Bullying and Supporting Beliefs: An Experimental Trial of the Steps to Respect Program.

Six schools were randomly assigned to a multilevel bullying intervention or a control condition. Children in Grades 3-6 (N=1,023) completed pre- and posttest surveys of behaviors and beliefs and were rated by teachers. Observers coded playground behavior of a random subsample (n=544). Hierarchical analyses of changes in playground behavior revealed declines in bullying and argumentative behavior among intervention-group children relative to control-group children, increases in agreeable interactions, and a trend toward reduced destructive bystander behavior. Those in the intervention group reported enhanced bystander responsibility, greater perceived adult responsiveness, and less acceptance of bullying/aggression than those in the control group. Self-reported aggression did not differ between the groups. Implications for future research on the development and prevention of bullying are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Adaptive topology optimization of elastoplastic structures

Material topology optimization is applied to determine the basic layout of a structure. The nonlinear structural response, e.g. buckling or plasticity, must be considered in order to generate a reliable design by structural optimization. In the present paper adaptive material topology optimization is extended to elastoplasticity. The objective of the design problem is to maximize the structural ductility which is defined by the integral of the strain energy over a given range of a prescribed displacement. The mass in the design space is prescribed. The design variables are the densities of the finite elements. The optimization problem is solved by a gradient based OC algorithm. An elastoplastic von Mises material with linear, isotropic work-hardening/softening for small strains is used. A geometrically adaptive optimization procedure is applied in order to avoid artificial stress singularities and to increase the numerical efficiency of the optimization process. The geometric parametrization of the design model is adapted during the optimization process. Elastoplastic structural analysis is outlined. An efficient algorithm is introduced to determine the gradient of the ductility with respect to the densities of the finite elements. The overall optimization procedure is presented and verified with design problems for plane stress conditions.     

高炉两段式喷吹煤粉工艺的生产实践

两段式喷吹煤粉工艺应用于瑞典SSAB Oxel(o)sund 2号高炉,效果显著.结果表明:若维持风口喷吹煤粉量不变,两段式喷吹煤粉工艺可以提高喷煤量,降低焦比,当第二段喷吹煤粉量5 kg/t时,焦比下降5 kg/t;改善高炉料柱透气性,降低料柱压差,使炉内煤气流分布更加合理,有助于高炉操作稳定,提高煤气利用率;第二段喷入的煤粉可以在高炉内被充分利用,并可以有效地抑制焦炭强度在高炉内的劣化,有助于降低在实施大喷煤工艺时对焦炭质量的苛刻要求;有助于减少炉墙热损失.     

Planar multimode detector arrays for infrared and millimeter-wave applications

A new type of detector array is described. By means of a suitably designed metallic network, many detector elements (each individually small compared to wavelength) are assembled into an impedance-matched termination for radiation incident normally on the plane of the device. Residual reactance is tuned out by means of a movable backshort. An array of 400 bismuth-film microbolometers with a total area of 1 cm²has been tested at 215 GHz. A coupling efficiency of approximately 60 percent was observed. The detector has aD*of4 times 10^{8}cm . Hz^1/2/W at room temperature with response time on the order of2 times 10^{-7}s. Similar arrays of Schottky and SIS diodes can probably be constructed.     

LXRα Regulates oxLDL-Induced Trained Immunity in Macrophages

Reprogramming of metabolic pathways in monocytes and macrophages can induce a proatherosclerotic inflammatory memory called trained innate immunity. Here, we have analyzed the role of the Liver X receptor (LXR), a crucial regulator of metabolism and inflammation, in oxidized low-density lipoprotein (oxLDL)-induced trained innate immunity. Human monocytes were incubated with LXR agonists, antagonists, and oxLDL for 24 h. After five days of resting time, cells were restimulated with the TLR-2 agonist Pam3cys. OxLDL priming induced the expression of LXRα but not LXRβ. Pharmacologic LXR activation was enhanced, while LXR inhibition prevented the oxLDL-induced inflammatory response. Furthermore, LXR inhibition blocked the metabolic changes necessary for epigenetic reprogramming associated with trained immunity. In fact, enrichment of activating histone marks at the IL-6 and TNFα promotor was reduced following LXR inhibition. Based on the differential expression of the LXR isoforms, we inhibited LXRα and LXRβ genes using siRNA in THP1 cells. As expected, siRNA-mediated knock-down of LXRα blocked the oxLDL-induced inflammatory response, while knock-down of LXRβ had no effect. We demonstrate a specific and novel role of the LXRα isoform in the regulation of oxLDL-induced trained immunity. Our data reveal important aspects of LXR signaling in innate immunity with relevance to atherosclerosis formation.     

Analyses of activity design in geometry in the light of student actions

Abstract

The goal of this study is to show that inquiry activities in a dynamic geometry environment, intentionally designed to confront students with contradictions and uncertainties, push them towards explanations that include deductive elements. Three different but dependent aspects of the activities are characterized and analysed: The epistemological, which includes all possible inquiry paths; the didactic, which involves only those paths that reflect the intention of the designer; and the cognitive, which accounts for actual student actions (conjectures and explanations) and their analyses. The research conclusions are based on the interplay among these three aspects. The analysis of students’ investigations and the analysis of their explanations fulfil, to a broad extent, the design goals.     

Identification of barramundi (Lates calcarifer) and tilapia (Oreochromis spp.) fillets by DNA- and protein-analytical methods

Fish and fillet of barramundi (Lates calcarifer) and tilapia (Oreochromis species) obtained from wholesale and retail trade were assigned to species by sequencing of PCR products. Two segments (358 and 464?bp) of the cytochrome b gene (cytb) were amplified using universal primers. The amplicons gave characteristic patterns in SSCP-analysis (single strand conformation polymorphism) suitable for differentiation of Lates calcarifer from Lates niloticus and Lateolabrax japonicus. Intra-specific variation of sequences and SSCP patterns were observed for barramundi. In case of tilapia species, it was found to be difficult to identify samples by BLAST due to the high similarity of cytb sequences of O. niloticus, O. mossambicus, O. aureus and Sarotherodon galileus. Four different patterns of single strand DNA (ssDNA) were obtained by SSCP analysis of the 464?bp amplicon of tilapia. Different patterns of ssDNA matched to variations in sequences. Protein profiles obtained by IEF (isoelectric focusing) of water-soluble proteins from raw fillet were found to be suitable for rapid differentiation of Lates calcarifer from Lateolabrax japonicus, but the three different Oreochromis species expressed only minor differences in protein patterns. The patterns of the tilapia and barramundi species showed a number of acidic, heat-stable proteins, presumably representing parvalbumin.