The influence of electric-field bending on the nonlinearity ofcapacitive sensors

Three-layered electrode structures are often employed in multiple-electrode capacitive position sensors. Even when advanced algorithms and well-designed guarding electrodes are used, the electric-field-bending effect is still one of the major contributors to the nonlinearity of capacitive position sensors. In this paper, the effects of electric-field bending on linearities of five capacitive linear-position sensors have been studied based on a physical model of the capacitive sensor. It is shown that the effect of electric-field bending on linearities strongly depends on the sensor structures, and that it is significantly reduced when advanced sensor structures and algorithms are used. The results are very useful for optimizing the sensor structure according to its application     

Review on the durability of exterior wood coatings with reduced VOC-content

The main factors that contribute to the durability of exterior wood coatings are discussed with special emphasis on the recent developments to reduce the volatile organic compound (VOC) content in these types of coating like water-borne acrylic dispersions, water-borne alkyds or high solid alkyd formulations. The performance of a coating during outdoor weathering is determined by: photochemical degradation (only for paints that are not opaque), moisture permeability in relation to wood-moisture content and dimensional change and the microbiological degradation at the wood–coating interface. The results from various outdoor weathering studies are discussed. These studies show fairly consistent results with respect to the influence of coating type or wood species. However, a sound theory about the mechanism of failure, that can related to basic properties of the coating or the binder, has not yet been established.     

Metabolic modelling of full-scale biological nitrogen and phosphorus removing wwtp's.

This paper evaluates the experiences with modelling full-scale biological phosphorus and nitrogen removing wastewater treatment plants. For the simulation, we used a metabolic phosphorus model integrated in ASM2d, further referred to as TUDP-model. It was found that the metabolic model for bio-P removal can be applied for modelling full-scale wwtp's, without extensive parameter adjustments. A stepwise modelling approach was proposed. Only three specific parameters were calibrated. Two parameters, the inert fraction in the influent and the actual anoxic sludge fraction will need calibration for all systems. Parameter sensitivity analyses showed that the sensitivity of operational data, often considered as known input data, is high. The model kinetics were found less sensitive. This will in general be the case for all low-loaded wwtp's recorded in their pseudo-steady state. Based on mass balance calculations, operational data and measurements were evaluated. Since all terms on a phosphorus balance can be measured, errors in operational data (e.g. SRT and flow rates) become very apparent in P-removal models (ASM2d, TUDP). We suggest using the P-balance in general for wwtp modelling, as a check on data consistency. This study showed that considering operational data per definition as known input data is not justified. Therefore, operational data should be evaluated, or considered in model calibration over the use of kinetic and stoichiometric parameters.     

Internal cathodic protection to study the erosion-corrosion of AISI 1018 carbon steel

Steel elbows used in pipelines carrying potash slurry may undergo material loss due to mechanical erosion and/or electrochemical corrosion. Cathodic protection was used to study the effects of flow velocity and slurry concentration on the protection current density required to maintain AISI 1018 carbon steel elbows at a set electric potential. A flow loop with a peristaltic pump was used to pump a slurry consisting of silica sand in a saturated potash brine through the steel elbows. The protection current density measurements were performed under varying slurry flow velocities of 2.5, 3.0, 3.5, and 4.0 m/s and varying slurry concentrations ranging from 0-35 wt%. The results show maximum values of protection current density were required for mid-range slurry concentrations. It is concluded that, within the parameters of study, high flow velocities require higher protection current density than low flow velocities. Furthermore, high flow velocities result in a local maximum protection current density being reached at lower slurry concentrations; conversely, a local maximum protection current density is reached at higher slurry concentrations in lower flow velocities. The contrast in local maximum protection current densities likely occurs due to additional particle-particle collisions at higher velocities causing the maximum mass transfer rate of oxygen to be reached at lower slurry concentrations. SEM micrographs show that wear becomes more evenly distributed with increasing flow velocity due to the homogeneous distribution of particles in the flowing medium.     

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

In mice, the mdr1a and mdr1b genes encode drug-transporting proteins that can cause multidrug resistance in tumor cells by lowering intracellular drug levels. These P-glycoproteins are also found in various normal tissues such as the intestine. Because mdr1b P-glycoprotein is not detectable in the intestine, mice with a homozygously disrupted mdr1a gene [mdr1a(-/-) mice] do not contain functional P-glycoprotein in this organ. We have used these mdr1a(-/-) mice to study the effect of gut P-glycoprotein on the pharmacokinetics of paclitaxel. The area under the plasma concentration-time curves was 2- and 6-fold higher in mdr1a(-/-) mice than in wild-type (wt) mice after i.v. and oral drug administration, respectively. Consequently, the oral bioavailability in mice receiving 10 mg paclitaxel per kg body weight increased from only 11% in wt mice to 35% in mdr1a(-/-) mice. The cumulative fecal excretion (0-96 hr) was markedly reduced from 40% (after i.v. administration) and 87% (after oral administration) of the administered dose in wt mice to below 3% in mdr1a(-/-) mice. Biliary excretion was not significantly different in wt and mdr1a(-/-) mice. Interestingly, after i.v. drug administration of paclitaxel (10 mg/kg) to mice with a cannulated gall bladder, 11% of the dose was recovered within 90 min in the intestinal contents of wt mice vs. <3% in mdr1a(-/-) mice. We conclude that P-glycoprotein limits the oral uptake of paclitaxel and mediates direct excretion of the drug from the systemic circulation into the intestinal lumen.